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José Félix Martí Massó
Instituto de Salud Carlos III
57Publications
16H-index
2,652Citations
Publications 57
Newest
1 CitationsSource
#2Luis J. AzconaH-Index: 5
Last.Coro Paisán-RuizH-Index: 34
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8 CitationsSource
#2Belén GagoH-Index: 12
Last.Maria C. Rodriguez-OrozH-Index: 33
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Background: No CSF or plasma biomarker has been validated for diagnosis or progression of PD. Objectives: To assess whether the CSF and plasma levels of proteins associated with PD neuropathological inclusions and with neuroinflammation might have value in the diagnosis of PD or in relation to disease severity. Methods: CSF levels of α-synuclein, amyloid-s1-42, total tau, and threonine-181 phosphorylated tau, as well as CSF and plasma levels of cytokines (interleukin-1s, interleukin-2, interleuk...
16 CitationsSource
#1Fermin MorenoH-Index: 13
Last.Suzee E. LeeH-Index: 18
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1 CitationsSource
#2Elisabet MondragonH-Index: 4
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#1Kathrin Brockmann (University of Tübingen)H-Index: 20
#2Anja Apel (University of Tübingen)H-Index: 8
Last.Walter Maetzler (University of Tübingen)H-Index: 38
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Background There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson’s disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory pathways. The objectives are to test (1) whether idiopathic PD and LRRK2-associated PD share common inflammatory pathways or present distinct profiles and (2) whether non-manifesting LRRK2 mut...
16 CitationsSource
Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions of people. Genome-wide association studies (GWAS) have found >25 genetic risk factors and at least 15 loci directly associated with PD. Recent advances in new next-generation DNA sequencing technologies, such as the semiconductor-based Ion Torrent platform, make multigene sequencing cheaper, faster, and more reliable.
5 CitationsSource
#2Jordi Solé-CasalsH-Index: 14
Last.Alberto Bergareche (UPV/EHU: University of the Basque Country)H-Index: 10
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Biomedical systems produce biosignals that arise from interaction mechanisms. In a general form, those mechanisms occur across multiple scales, both spatial and temporal, and contain linear and non-linear information. In this framework, entropy measures are good candidates in order provide useful evidence about disorder in the system, lack of information in time-series and/or irregularity of the signals. The most common movement disorder is essential tremor (ET), which occurs 20 times more than ...
10 CitationsSource
Background The objective of this study was to study motor and nonmotor symptoms and striatal dopaminergic denervation, as well as the relationship between them, in a cohort of asymptomatic relatives of patients with Parkinson's disease (PD) with the R1441G-leucine-rich repeat kinase 2 mutation. Methods Asymptomatic relatives of patients with PD and this mutation were tested for the presence of the mutation and evaluated for striatal, putamenal, and caudate dopaminergic transporters using 123I-2β...
18 CitationsSource
#1Patricia de la Riva (UPV/EHU: University of the Basque Country)
#2Maria Teresa Martínez-Zabaleta (UPV/EHU: University of the Basque Country)
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A 30-year-old woman suffered from acute vertebrobasilar stroke. Cranial tomography (CT) scans showed multiple vertebral abnormalities suggestive of congenital spine malformation, and angiographic CT revealed aneurysmal dilatations (ADs) at segment V2 of both vertebral arteries (VAs). Dynamic neuroimaging tests including angiography and angio-CT were performed and showed occlusion of both VAs at the point of the ADs with contralateral rotation of the neck. The presence of a bony structure causing...
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