Jason M. Brenchley
National Institutes of Health
Publications 146
ABSTRACT Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus clearance and pathogenesis is unclear. Here, we studied how Zika virus (ZIKV) infection is modulated in SIV-infected nonhuman primates. We measured ZIKV replication, cellular ZIKV RNA levels, and immune responses in non-SIV-infected and SI...
#1Liang Ma (NIH: National Institutes of Health)H-Index: 24
#2Zehua Chen (MIT: Massachusetts Institute of Technology)H-Index: 19
Last.A KovacsJoseph (NIH: National Institutes of Health)H-Index: 67
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Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multi-copy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species characterized to date, highlighting its important role in Pneumocystis biology. In this report, through a comprehensive and in-depth characterization of 459 msg genes from 7 Pneumocystis species, we dem...
#1Ornella Sortino (NIH: National Institutes of Health)H-Index: 1
#2Nittaya PhanuphakH-Index: 21
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#1Alexandra M. OrtizH-Index: 14
#2Jacob K. FlynnH-Index: 1
Last.Jason M. BrenchleyH-Index: 58
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#1Joseph C. Mudd (NIH: National Institutes of Health)H-Index: 13
#2Jason M. Brenchley (NIH: National Institutes of Health)H-Index: 58
Purpose of Review The discovery of innate lymphoid cells (ILCs) over the past decade has reformed principles that were once thought to be exclusive to adaptive immunity. Here, we describe ILC nomenclature and function, and provide a survey of studies examining these cells in the context of HIV/SIV infections. Particular emphasis is placed on the ILC3 subset, important for proper functioning of the gastrointestinal tract barrier.
1 CitationsSource
#1Stephen H. LaiH-Index: 2
#2Carly E. StarkeH-Index: 1
Last.Jason M. BrenchleyH-Index: 58
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1 CitationsSource
#1Michael J. TiszaH-Index: 3
#2Diana V. PastranaH-Index: 24
Last.Christopher B. BuckH-Index: 40
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Although it is suspected that there are millions of distinct viral species, fewer than 9,000 are catalogued in GenBank9s RefSeq database. We selectively enriched for and amplified the genomes of circular DNA viruses in over 70 animal samples, ranging from cultured soil nematodes to human tissue specimens. A bioinformatics pipeline, Cenote-Taker, was developed to automatically annotate over 2,500 circular genomes in a GenBank-compliant format. The new genomes belong to dozens of established and e...
3 CitationsSource
#1Joseph C. Mudd (NIH: National Institutes of Health)H-Index: 13
#2Kathleen Busman-Sahay (Oregon National Primate Research Center)H-Index: 3
Last.Jason M. Brenchley (NIH: National Institutes of Health)H-Index: 58
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Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLNs), yet preserved in SIV+ RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs, experimental depletion of CD4+ T cells in combination with d...
4 CitationsSource
#1Alexandra M. Ortiz (NIH: National Institutes of Health)H-Index: 14
#2Jacob K. Flynn (NIH: National Institutes of Health)H-Index: 1
Last.Jason M. Brenchley (NIH: National Institutes of Health)H-Index: 58
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Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis simila...
12 CitationsSource