Jason M. Brenchley
National Institutes of Health
VirologyImmunologyT cellSimian immunodeficiency virusBiology
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Publications 162
#1Ivan Vujkovic-Cvijin (NIH: National Institutes of Health)H-Index: 14
#2Ornella Sortino (NIH: National Institutes of Health)H-Index: 1
view all 13 authors...
Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior observations of gut microbiota alterations among persons with HIV (PWH). To overcome this and other confounding factors, we examine a well-powered subset of AGEhIV Cohort participa...
1 CitationsSource
#1Carol L. Vinton (NIH: National Institutes of Health)H-Index: 17
#2Carly E. Starke (NIH: National Institutes of Health)H-Index: 2
Last. Jason M. BrenchleyH-Index: 12
view all 9 authors...
Background: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation. Microbial components that trans-locate from the lumen of the GI tract directly stimulate the immune system and contribute to inflammation. When microbial translocation becomes chronic, the inflammation has detrimental consequences. Given that microbial translocation is an important phenomenon in many diseases, defining biomarkers that reliabl...
#1Cheri A. Lee (NIH: National Institutes of Health)H-Index: 1
#2Erin Beasley (NIH: National Institutes of Health)
Last. Bernard A. P. Lafont (NIH: National Institutes of Health)H-Index: 16
view all 12 authors...
Simian immunodeficiency virus (SIV)-infected nonhuman primates can serve as a relevant model for AIDS neuropathogenesis. Current SIV-induced encephalitis (SIVE)/neurological complications of AIDS (neuroAIDS) models are generally associated with rapid progression to neuroAIDS, which does not reflect the tempo of neuroAIDS progression in humans. Recently, we isolated a neuropathogenic clone, SIVsm804E-CL757 (CL757), obtained from an SIV-infected rhesus macaque (RM). CL757 causes a more protracted ...
#1Michael D. Lewis (Lond: University of London)H-Index: 32
#2Andrea PaunH-Index: 3
Last. David L. SacksH-Index: 78
view all 10 authors...
Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, specifically post-kala-azar dermal leishmaniasis (PKDL). Nevertheless, the majority of infected people are asymptomatic carriers. Hamsters and mice are commonly used as models of fatal and non-fatal VL, respectively. Host and parasite genetics are like...
#1Liang Ma (NIH: National Institutes of Health)H-Index: 2
#1Liang MaH-Index: 25
Last. Magali Chabé (Pasteur Institute)H-Index: 20
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ABSTRACT Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multicopy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species characterized to date, highlighting its important role in Pneumocystis biology. In this report, through a comprehensive and in-depth characterization of 459 msg genes from 7 Pneumocystis species...
1 CitationsSource
#1Yetao Wang (UMMS: University of Massachusetts Medical School)H-Index: 1
#2Lawrence M. Lifshitz (UMMS: University of Massachusetts Medical School)H-Index: 32
Last. Smita Jaiswal (UMMS: University of Massachusetts Medical School)H-Index: 9
view all 21 authors...
Human immunodeficiency virus 1 (HIV-1) infection is associated with heightened inflammation and excess risk of cardiovascular disease, cancer and other complications. These pathologies persist despite antiretroviral therapy. In two independent cohorts, we found that innate lymphoid cells (ILCs) were depleted in the blood and gut of people with HIV-1, even with effective antiretroviral therapy. ILC depletion was associated with neutrophil infiltration of the gut lamina propria, type 1 interferon ...
1 CitationsSource
CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that dictate antiviral potency remain elusive, conceivably because most studies to date have been restricted to analyses of circulating CD8+ T cells. We conducted a detailed clonotypic, functional, and phenotypic survey of SIV-specific CD8+ T cells across multiple anatomical sites in chronically infected rhesus macaques with high (>10,000 copies/mL plasma) or low burdens of ...
1 CitationsSource
#1Rachel L. Rutishauser (UCSF: University of California, San Francisco)H-Index: 8
#2Christian Deo T Deguit (NIH: National Institutes of Health)H-Index: 2
Last. Peter W. Hunt (UCSF: University of California, San Francisco)H-Index: 60
view all 26 authors...
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key feature of exhaustion; little is known, however, about how these properties are regulated in human virus-specific CD8+ T cells. We found that virus-specific CD8+ T cells from humans and non-human primates naturally cont...
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 2
#2Diana V. Pastrana (NIH: National Institutes of Health)H-Index: 10
Last. David H. McDermott (NIH: National Institutes of Health)H-Index: 34
view all 26 authors...
2 CitationsSource
#1Carol L. Vinton (NIH: National Institutes of Health)H-Index: 17
#2Samuel J. Magaziner (NIH: National Institutes of Health)H-Index: 1
Last. Jason M. Brenchley (NIH: National Institutes of Health)H-Index: 61
view all 14 authors...
ABSTRACT Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus clearance and pathogenesis is unclear. Here, we studied how Zika virus (ZIKV) infection is modulated in SIV-infected nonhuman primates. We measured ZIKV replication, cellular ZIKV RNA levels, and immune responses in non-SIV-infected and SI...
3 CitationsSource