Christina G. Selkirk
University of Chicago
Publications 18
#1Christos Mikropoulos (U of C: University of Chicago)H-Index: 4
#2Christina G. Selkirk (U of C: University of Chicago)H-Index: 8
Last.Rosalind A. Eeles (U of C: University of Chicago)H-Index: 93
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BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in m...
7 CitationsSource
#1Amy A. Lemke (NorthShore University HealthSystem)H-Index: 4
#2Christina G. Selkirk (NorthShore University HealthSystem)H-Index: 8
Last.Henry M. Dunnenberger (NorthShore University HealthSystem)H-Index: 12
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Aim: To explore primary care physicians’ views of the utility and delivery of direct access to pharmacogenomics (PGx) testing in a community health system. Methods: This descriptive study assessed the perspectives of 15 healthcare providers utilizing qualitative individual interviews. Results: Three main themes emerged: perceived value and utility of PGx testing; challenges to implementation in practice; and provider as well as patient needs. Conclusion: While providers in this study viewed bene...
12 CitationsSource
#1Lauren Rudichuk (NU: Northwestern University)H-Index: 1
#2Kristen J. Vogel (GeneDx)H-Index: 1
Last.Christina G. Selkirk (NorthShore University HealthSystem)H-Index: 8
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Objective To assess urologists' knowledge and utilization of family history to determine prostate cancer (PC) screening and treatment recommendations. Materials and Methods Questionnaires that explored urologists' knowledge, frequency, and utilization of family history information for screening and treatment recommendations for PC were prospectively collected. Data were summarized and compared using descriptive statistics. Results A total of 87 responses were collected, for a response rate of 60...
1 CitationsSource
#1Jessica Stoll (U of C: University of Chicago)H-Index: 3
#2Scott M. Weissman (GeneDx)H-Index: 8
Last.Kristen J. Vogel Postula (GeneDx)H-Index: 3
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Genetic counseling and testing for hereditary cancer susceptibility is a rapidly evolving field and partly a result of next-generation sequencing (NGS) allowing analysis of multiple cancer susceptibility genes simultaneously. This qualitative study explored laboratory perspectives on hereditary cancer panels. Semi-structured interviews were conducted with representatives of clinical laboratories offering hereditary cancer panels via NGS. Several themes emerged from the responses pertaining to he...
3 CitationsSource
#1Christina G. Selkirk (NorthShore University HealthSystem)H-Index: 8
#2Brian T. Helfand (NorthShore University HealthSystem)H-Index: 33
#1Timothy R. Rebbeck (UPenn: University of Pennsylvania)H-Index: 80
#2Nandita Mitra (UPenn: University of Pennsylvania)H-Index: 46
Last.Irene L. Andrulis (Lunenfeld-Tanenbaum Research Institute)H-Index: 39
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Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
134 CitationsSource
#1Christina G. Selkirk (NorthShore University HealthSystem)H-Index: 8
#2Chi Hsiung Wang (NorthShore University HealthSystem)H-Index: 5
Last.Brian T. Helfand (NorthShore University HealthSystem)H-Index: 33
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Objective To assess whether men with a family history of prostate cancer are more likely to fail active surveillance because of recategorization of their tumors on subsequent surveillance biopsies. Methods Men enrolled in an institutional review board–approved active surveillance program were studied, and data on first- and/or second-degree family history of prostate cancer was collected. Analyses were performed to compare the frequency of family history with recategorization (higher grade or vo...
5 CitationsSource
16 Background: We retrospectively assessed the clinical application of Prostate Specific Antigen Velocity (PSA V) in the IMPACT study (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in men at higher genetic risk and controls). This is a case-control prostate cancer (PrCa) screening study for men with a known genetic predisposition to PrCa; participants with a single PSA reading above 3ng/ml are offered diagnostic TRUS prostate biopsies (PB). Methods: W...