Leila Rooshenas
University of Bristol
Randomized controlled trialPhysical therapyQualitative researchPsychological interventionMedicine
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Publications 99
#1Carmel Conefrey (UoB: University of Bristol)H-Index: 2
#2Jenny L Donovan (UoB: University of Bristol)H-Index: 86
Last. Helena M. EarlH-Index: 42
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Aims: De-escalation trials are challenging and sometimes may fail due to poor recruitment. The OPTIMA Prelim randomised controlled trial (ISRCTN42400492) randomised patients with early stage breast cancer to chemotherapy versus ‘test-directed’ chemotherapy, with a possible outcome of no chemotherapy, which could confer less treatment relative to routine practice. Despite encountering challenges, OPTIMA Prelim reached its recruitment target ahead of schedule. This study reports the root causes of...
#1Ben E. Byrne (UoB: University of Bristol)H-Index: 4
#2Leila Rooshenas (UoB: University of Bristol)H-Index: 9
Last. Jane M Blazeby (UoB: University of Bristol)H-Index: 62
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BACKGROUND: While randomised controlled trials (RCTs) provide high-quality evidence to guide practice, much routine care is not based upon available RCTs. This disconnect between evidence and practice is not sufficiently well understood. This case study explores this relationship using a novel approach. Better understanding may improve trial design, conduct, reporting and implementation, helping patients benefit from the best available evidence. METHODS: We employed a case-study approach, compri...
#1Robert C Stein (NIHR: National Institute for Health Research)H-Index: 37
#1J SteinRobert (NIHR: National Institute for Health Research)
Last. Bjørn Naume (Oslo University Hospital)H-Index: 39
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Background: Multi-parameter tumour gene expression assays (MPAs) are widely used to estimate individual patient risk and to guide chemotherapy use in hormone-sensitive, HER2-negative early breast cancer. The TAILORx trial supports MPA use in a node-negative population. Evidence in node-positive breast cancer is limited. OPTIMA (Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis) (ISRCTN42400492) is a prospective international randomised controlled trial (RCT) de...
#1Katherine J. Rennie (Newcastle University)H-Index: 15
Last. David W. Hamilton (Freeman Hospital)H-Index: 8
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BACKGROUND: Septoplasty (surgery to straighten a deviation in the nasal septum) is a frequently performed operation worldwide, with approximately 250,000 performed annually in the US and 22,000 in the UK. Most septoplasties aim to improve diurnal and nocturnal nasal obstruction. The evidence base for septoplasty clinical effectiveness is hitherto very limited. AIMS: To establish, and inform guidance for, the best management strategy for individuals with nasal obstruction associated with a deviat...
#1Richard ArmstrongH-Index: 4
#2Caroline Wilson (UoB: University of Bristol)H-Index: 11
Last. Leila Rooshenas (UoB: University of Bristol)H-Index: 9
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We conducted a survey and semi-structured qualitative interviews to investigate current anaesthetic practice for arteriovenous fistula formation surgery in the UK. Responses were received from 39 out of 59 vascular centres where arteriovenous access surgery is performed, a response rate of 66%. Thirty-five centres reported routine use of brachial plexus blocks, but variation in anaesthetic skill-mix and practice were observed. Interviews were conducted with 19 clinicians from 10 NHS Trusts inclu...
1 CitationsSource
#1Christel McMullan (University of Birmingham)H-Index: 8
#2Jane M Blazeby (University Hospitals Bristol NHS Foundation Trust)H-Index: 62
Last. Jonathan Mathers (University of Birmingham)H-Index: 15
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Primary surgical abdominal wounds are usually covered with a dressing. However, little is known about the practical issues and costs around these dressings. This study aimed to provide an in-depth ...
#1Nicola Harman (University of Liverpool)H-Index: 12
#2Daisy Elliott (UoB: University of Bristol)H-Index: 8
Last. Gillian W. Shorter (Ulster University)H-Index: 13
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#1Christel McMullan (University of Birmingham)H-Index: 8
#2Jane M Blazeby (UoB: University of Bristol)H-Index: 62
Last. Rhiannon C MacefieldH-Index: 14
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#1Timothy JonesH-Index: 10
#2Andrew Carr (University of Oxford)H-Index: 95
Last. William HollingworthH-Index: 46
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Objectives To illustrate the need for better evaluation of surgical procedures, we investigated the use and cost of subacromial decompression in England over the last decade compared with other countries and explored how this related to the conduct and outcomes of randomised, placebo-controlled clinical trials. Design Longitudinal observational study using Hospital Episode Statistics linked to Payment by Results tariffs in England, 2007/2008 to 2016/2017. Setting Hospital care in England; Finlan...
2 CitationsSource
#1Barnaby C Reeves (UoB: University of Bristol)H-Index: 55
#2Leila Rooshenas (UoB: University of Bristol)H-Index: 9
Last. Ananthavarathan P Blazeby Jm (University Hospitals Bristol NHS Foundation Trust)
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: Wound infections are common after surgery. Some are cured with simple treatment, but others may lead to serious problems. Reducing the risk of a wound infection is important. We do not know if the type of dressing, or not using a dressing, influences the risk of infection. A study that allocated patients to receive different dressings (or no dressing) would answer this question. We did preliminary research to explore whether or not such a study is possible. We interviewed doctors, nurses and p...
1 CitationsSource