Jeffrey C. Glennon
Radboud University Nijmegen
Publications 80
#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Sarita A. Dam (Radboud University Nijmegen)
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 8 authors...
Abstract Learning from feedback is one of the key mechanisms within cognitive flexibility, which is needed to react swiftly to constantly changing environments. The motivation to change behavior is highly dependent on the expectancy of positive (reward) or negative (punishment) feedback. Individuals with conduct disorder (CD) with high callous unemotional traits show decreased sensitivity to negative feedback and increased reward seeking. Previous studies have modelled traits associated with CD ...
#1Michael C. Craig ('KCL': King's College London)H-Index: 29
#2Leandra M Mulder (Radboud University Nijmegen)H-Index: 1
Last.Jilly Naaijen (Radboud University Nijmegen)H-Index: 6
view all 23 authors...
Abstract Disruptive behavior is associated with societally and personally problematic levels of aggression and has been linked to abnormal structure and function of fronto-amygdala-striatal regions. Abnormal glutamatergic signalling within this network may play a role in aggression. However, disruptive behavior does not represent a homogeneous construct, but can be fractionated across several dimensions. Of particular interest, callous-unemotional (CU) traits have been shown to modulate the seve...
#1Ilse I.G.M. van de Vondervoort (Radboud University Nijmegen)H-Index: 3
#2Ilse I. G. M. van de Vondervoort (Radboud University Nijmegen)H-Index: 1
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 13 authors...
Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we identified insulin signaling being associated with OCD and here, we aim to further investigate this link in vivo. We studied TALLYHO/JngJ (TH) mice, a model of type 2 diabetes mellitus, to (1) assess compulsive and anxious behaviors, (2) determine neuro-metabolite levels by 1 H ma...
2 CitationsSource
#1Sylvia Nieuwenhuis (Radboud University Nijmegen)
#2Kees Okkersen (Radboud University Nijmegen)H-Index: 4
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 7 authors...
Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterised by multi-system involvement. Affected organ system include skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidence for alterations in insulin signalling and their relation to clinical DM1 features. We start by summarising the molecular pathophysiology of DM1. Next, an overview of normal insulin signalling physiology is given, and evidence for alterations herein ...
#2F. MogaveroH-Index: 1
Last.Martha N. HavenithH-Index: 5
view all 9 authors...
Overt aggression, increased anxiety, and dysfunctional fear processing are often observed in individuals with conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD). Methylphenidate (MPH), a psychostimulant increasing dopamine and noradrenaline tone, is effective in reducing aggression in both CD and ADHD individuals. However, it is unclear to which extent these effects of MPH are dose dependent. Here, the effects of acute intraperitoneal MPH (3 and 10 mg/kg) on aggression, an...
#1I. Hyun Ruisch (UMCG: University Medical Center Groningen)H-Index: 2
#2Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
Last.Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 5 authors...
We investigated gene–environment (G × E) interactions related to childhood antisocial behavior between polymorphisms implicated by recent genome-wide association studies (GWASs) and two key environmental adversities (maltreatment and smoking during pregnancy) in a large population cohort (ALSPAC). We also studied the MAOA candidate gene and addressed comorbid attention-deficit/hyperactivity disorder (ADHD). ALSPAC is a large, prospective, ethnically homogeneous British cohort. Our outcome consis...
#1Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
#2Laura E.R. Blok (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 14 authors...
Abstract Background Although habituation is one of the most ancient and fundamental forms of learning, its regulators and its relevance for human disease are poorly understood. Methods We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and we tested these models in light-off jump habituation. We dissected neuronal substrates underlying the identified habituation deficits ...
1 CitationsSource
#1Luca Pagliaroli (Semmelweis University)H-Index: 3
#2Joanna Widomska (Radboud University Nijmegen)H-Index: 1
Last.Geert Poelmans (Radboud University Nijmegen)H-Index: 14
view all 8 authors...
Chronic administration of L-DOPA, the first-line treatment of dystonic symptoms in childhood or in Parkinson’s disease, often leads to the development of abnormal involuntary movements (AIMs), which represent an important clinical problem. Although it is known that Riluzole attenuates L-DOPA-induced AIMs, the molecular mechanisms underlying this effect are not understood. Therefore, we studied the behavior and performed RNA sequencing of the striatum in three groups of rats that all received a u...
#1Syanah C. Wynn (Radboud University Nijmegen)H-Index: 2
#2Josi M. A. Driessen (Radboud University Nijmegen)H-Index: 2
Last.Dennis J.L.G. Schutter (Radboud University Nijmegen)H-Index: 37
view all 5 authors...
Involvement of the cerebellum to non-motor related aspects of behavior is becoming increasingly clear. The aim of this study was to investigate the role of the cerebellum in reactive and proactive behavioral control and interference. In a double-blind controlled within-subject design, 26 healthy volunteers underwent real and sham cerebellar transcranial direct current stimulation (tDCS) while performing a go/no-go task and a delay discounting task. Results showed that the number of go/no-go comm...