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Matthew D. Phaneuf
Beth Israel Deaconess Medical Center
SurgeryComposite materialMaterials scienceBiomaterialMedicine
46Publications
16H-index
536Citations
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Publications 46
Newest
#1Yael Vin (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 8
#2Saif G. PathanH-Index: 3
Last. Matthew D. PhaneufH-Index: 16
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Polyvinyl alcohol (PVA) is a synthetic, water-soluble polymer, with applications in industries ranging from textiles to biomedical devices. Research on electrospinning of PVA has been targeted toward optimizing or finding novel applications in the biomedical field. However, the effects of electrospinning on PVA biocompatibility have not been thoroughly evaluated. In this study, the cytotoxicity of electrospun PVA (nPVA) which was not crosslinked after electrospinning was assessed. PVA polymers o...
5 CitationsSource
#1Christoph S. Nabzdyk (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 12
#2Maggie Chun (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Leena Pradhan Nabzdyk (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 18
view all 8 authors...
Intimal hyperplasia (IH), an excessive wound healing response of an injured vessel wall after bypass grafting, typically leads to prosthetic bypass graft failure. In an approach to ameliorate IH, nondegradable poly(ethylene terephthalate) or PET, which has been used in prosthetic vascular grafts for over 60 years, and biodegradable poly(glycolic acid) or PGA were electrospun using different techniques to generate a material that may serve as permanent scaffold and as a drug/biologic delivery dev...
4 CitationsSource
#1Shawn Regis (UMassD: University of Massachusetts Dartmouth)H-Index: 3
#2Sina Youssefian (WPI: Worcester Polytechnic Institute)H-Index: 7
Last. Sankha Bhowmick (UMassD: University of Massachusetts Dartmouth)H-Index: 17
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Protein adsorption and receptor-ligand binding are two key first steps in the cell adhesion process. The ability to predetermine the success or failure of these processes would significantly advance the field of tissue engineering. This study examines fibronectin adsorption on functionalized electrospun polycaprolactone (PCL) scaffolds and determines the affinity of cell receptors for the adsorbed fibronectin onto each scaffold. After determining the affinity values, model plots were developed f...
4 CitationsSource
#1Shawn Regis (UMassD: University of Massachusetts Dartmouth)H-Index: 3
#2Sina Youssefian (WPI: Worcester Polytechnic Institute)H-Index: 7
Last. Sankha Bhowmick (UMassD: University of Massachusetts Dartmouth)H-Index: 17
view all 6 authors...
Designing scaffolds to modulate protein adsorption is a key to building advanced scaffolds for tissue regeneration. Protein adsorption to tissue engineering scaffolds is critical in early cell attachment, survival, and eventual proliferation. The goal of this study is to examine the effect of functionalization on fibronectin adsorption to electrospun polycaprolactone (PCL) scaffolds through experimentation using fluorescently labeled fibronectin and to couple this experimental data with analysis...
16 CitationsSource
Apr 1, 2014 in NEBEC (Northeast Bioengineering Conference)
#1Nurazhani A. Raof (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
#2Wande B. Pratt (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 17
Last. Matthew D. PhaneufH-Index: 16
view all 7 authors...
Intimal hyperplasia (IH) remains one of the primary causes of prosthetic vascular graft failure. The goal of this study is to engineer a vascular graft material that has the ability to knock down genes associated with IH by local delivery of a select siRNA moiety to cells surrounding the implant. Thrombospondin-2 (TSP-2), previously shown to have increased expression during graft implantation, is a logical candidate for knock down. TSP-2 siRNA, alone and when complexed with the transfection reag...
Source
#1Shannon LindermanH-Index: 1
#2Joel Araya (NU: Northeastern University)H-Index: 1
Last. Mauricio A. Contreras (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 13
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1 Citations
#1Christoph S. Nabzdyk (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 12
#2Maggie Chun (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
view all 8 authors...
Abstract An excessive tissue response to prosthetic arterial graft material leads to intimal hyperplasia (IH), the leading cause of late graft failure. Seroma and abnormal capsule formation may also occur after prosthetic material implantation. The matricellular protein Thrombospondin-2 (TSP-2) has shown to be upregulated in response to biomaterial implantation. This study evaluates the uptake and release of small interfering RNA (siRNA) from unmodified and surface functionalized electrospun PET...
20 CitationsSource
#1Christoph S. Nabzdyk (Tufts University)H-Index: 12
#2Maggie Chun (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
view all 8 authors...
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#1Maggie Chun (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2H.S. Oliver-Allen (IU: Indiana University)
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
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