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Justine Fam
University of New South Wales
11Publications
4H-index
39Citations
Publications 12
Newest
#1James W. Crane (UTAS: University of Tasmania)H-Index: 13
#2Nathan M. Holmes (UNSW: University of New South Wales)H-Index: 9
Last.Andrew J. Delaney (CSU: Charles Sturt University)H-Index: 10
view all 5 authors...
Oxytocin (OT) is a neuroactive peptide that influences the processing of fearful stimuli in the amygdala. In the central nucleus of the amygdala, the activation of OT-receptors alters neural activi...
Source
#1Justine Fam (UNSW: University of New South Wales)H-Index: 4
#2Jessica C. Lee (UNSW: University of New South Wales)H-Index: 4
The number of students enrolling in postgraduate by research degrees has seen a large increase in recent years, a trend which is evident globally as well as within Australia. However, the rate at which PhD students are dropping out has also increased, indicating that students are not receiving adequate resources to support them throughout their candidature. We highlight that mentoring programs are effective in addressing inequality between PhD students, and describe a program that we have recent...
Source
#1Andrew J. Delaney (CSU: Charles Sturt University)H-Index: 10
#2James W. Crane (UTAS: University of Tasmania)H-Index: 13
Last.R. F. Westbrook (UNSW: University of New South Wales)H-Index: 25
view all 5 authors...
The two main sub-divisions of the Central amygdala (CeA), the lateral-capsular (CeA-LC) and the medial (CeA-M), contain extensive networks of inhibitory interneurons. We have previously shown that activation of GABAB-receptors reduces excitatory transmission between axons of the pontine parabrachial nucleus and neurons of the CeA-LC by inhibiting glutamate release from presynaptic terminals13. Here we have characterised GABAB-receptor activation on other excitatory and inhibitory projections wit...
4 CitationsSource
#1Justine Fam (UNSW: University of New South Wales)H-Index: 4
#2Nathan M. Holmes (UNSW: University of New South Wales)H-Index: 9
Last.R. Frederick Westbrook (UNSW: University of New South Wales)H-Index: 29
view all 5 authors...
Oxytocin (OT) is a neuropeptide which influences the expression of social behavior and regulates its distribution according to the social context - OT is associated with increased pro-social effects in the absence of social threat and defensive aggression when threats are present. The present experiments investigated the effects of OT beyond that of social behavior by using a discriminative Pavlovian fear conditioning protocol with rats. In Experiment 1, an OT receptor agonist (TGOT) microinject...
2 CitationsSource
#1Nathan M. Holmes (UNSW: University of New South Wales)H-Index: 9
#2James W. Crane (CSU: Charles Sturt University)H-Index: 13
Last.Andrew J. Delaney (CSU: Charles Sturt University)H-Index: 10
view all 6 authors...
The central amygdala is critical for the acquisition and expression of fear memories. This region receives a dense innervation from brainstem noradrenergic cell groups and has a high level of α2-adrenoceptor expression. Using whole-cell electrophysiological recordings from rat brain slices, we characterise the role of pre-synaptic α2-adrenoceptor in modulating discrete inhibitory and excitatory connections within both the lateral and medial division of the central amygdala. The selective α2-adre...
4 CitationsSource
2 CitationsSource
#1Carmen Huynh (UNSW: University of New South Wales)H-Index: 1
#2Justine Fam (UNSW: University of New South Wales)H-Index: 4
Last.Kelly J. Clemens (UNSW: University of New South Wales)H-Index: 18
view all 4 authors...
Drug use may be exacerbated in environments which lack alternative means of engaging in rewarding behaviour. When alternative rewards are available, drug use may decrease-an effect that can be harnessed for therapeutic benefit. This idea is particularly well-supported by recent preclinical evidence demonstrating that a majority of rats will readily choose a potent non-drug reward over cocaine or heroin. Here we examine whether the same holds true for nicotine, a drug considered to have one of th...
19 CitationsSource
#1Justine FamH-Index: 4
#2Fred WestbrookH-Index: 4
Last.Ehsan ArabzadehH-Index: 22
view all 3 authors...
Identifying similarities and differences in choice behavior across species is informative about how basic mechanisms give rise to more complex processes. In the present study, we compared pre- and post-choice latencies between rats and humans under two paradigms. In Experiment 1, we used a cued choice paradigm where subjects were presented with a cue that directed them as to which of two options to respond for rewards. In Experiment 2, subjects were free to choose between two options in order to...
Source
#1Nathan M. Holmes (UNSW: University of New South Wales)H-Index: 9
#2Kate Hutton-Bedbrook (UNSW: University of New South Wales)H-Index: 1
Last.R. Frederick Westbrook (UNSW: University of New South Wales)H-Index: 29
view all 4 authors...
Source
#1Justine Fam (UNSW: University of New South Wales)H-Index: 4
#2Fred Westbrook (UNSW: University of New South Wales)H-Index: 4
Last.Ehsan Arabzadeh (ANU: Australian National University)H-Index: 22
view all 3 authors...
One characteristic of natural environments is that outcomes vary across time. Animals need to adapt to these environmental changes and adjust their choices accordingly. In this experiment, we investigated the sensitivity with which rats could detect, and adapt to, multiple changes in the environment. Rats chose between two spouts which delivered 5% sucrose rewards with distinct probabilities. Across three phases, reward probabilities changed in size (large or small) and direction (increase or de...
2 CitationsSource
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