Lynne R. Wilkens
University of Hawaii
CancerCohort studyPopulationMedicineCohort
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Publications 581
#1Chun-Han Lo (Harvard University)
#2Long H. Nguyen (Harvard University)H-Index: 15
Last. Raaj S. Mehta (Harvard University)H-Index: 12
view all 29 authors...
Background Racial and ethnic minorities have disproportionately high hospitalization rates and mortality related to the novel coronavirus disease 2019 (Covid-19). There are comparatively scant data on race and ethnicity as determinants of infection risk. Methods We used a smartphone application (beginning March 24, 2020 in the United Kingdom [U.K.] and March 29, 2020 in the United States [U.S.]) to recruit 2,414,601 participants who reported their race/ethnicity through May 25, 2020 and employed...
#1Filipe C. Martins (University of Cambridge)H-Index: 5
#2Dominique-Laurent Couturier (University of Cambridge)H-Index: 7
Last. Alexander HeinH-Index: 27
view all 97 authors...
BACKGROUND PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression as a biomarker in epithelial ovarian cancer in a large population-based study. METHODS Tumours from 5400 patients from a multicentre observational, prospective cohort study of the Ovarian Tumour Tissue Analysis Consortium were used to evaluate associations between immunohis...
#1Aline Talhouk (UBC: University of British Columbia)H-Index: 13
#2Joshy GeorgeH-Index: 34
Last. Maria P. Intermaggio (SC: University of Southern California)H-Index: 9
view all 124 authors...
Purpose: Gene-expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by non-standardized methods which are not applicable in a clinical setting. We sought to generate a clinical-grade minimal gene-set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously repor...
#1Hongwei Tang (University of Texas MD Anderson Cancer Center)
#2Lai Jiang (Harvard University)
Last. Steven Gallinger (Lunenfeld-Tanenbaum Research Institute)H-Index: 90
view all 71 authors...
Background:Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants and diabetes/obesity have not previously been comprehensively investigated in pancreatic cancer at the genome-wide level. Methods:We conducted a gene-environment interaction (GxE) analysis including 8,255 cases and 11,900 controls from four pancreatic cancer GWAS datasets (PanScan I-III and PanC4). Obesity (BMI=30 kg/m2) and diabetes (duration = 3 years) were the environ...
#1Brook E. Harmon (U of M: University of Memphis)H-Index: 13
#2Yurii B. Shvetsov (UH: University of Hawaii)H-Index: 22
Last. Loic Le Marchand (UH: University of Hawaii)H-Index: 91
view all 8 authors...
Objective: While cardiometabolic abnormalities are associated with elevated risk of morbidity, they may not occur in all individuals with obesity. Less is known about associations with mortality, e...
#1Meng Lin (SC: University of Southern California)
#2Christian CabertoH-Index: 13
Last. Jacqueline Porcel (SC: University of Southern California)H-Index: 7
view all 17 authors...
Statistical imputation applied to genome-wide array data is the most cost-effective approach to complete the catalog of genetic variation in a study population. However, imputed genotypes in underrepresented populations incur greater inaccuracies due to ascertainment bias and a lack of representation among reference individuals, further contributing to the obstacles to study these populations. Here we examined the consequences due to the lack of representation by genotyping in a large number of ...
#1Ani Manichaikul (UVA: University of Virginia)H-Index: 37
#1Ani Manichaikul (UVA: University of Virginia)H-Index: 7
Last. Joellen M. SchildkrautH-Index: 62
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: Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10-6 ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (...
2 CitationsSource
#1Song-Yi Park (UH: University of Hawaii)H-Index: 25
#2Yurii B. Shvetsov (UH: University of Hawaii)H-Index: 22
Last. Loic Le Marchand (UH: University of Hawaii)H-Index: 91
view all 7 authors...
#1Gertraud Maskarinec (UH: University of Hawaii)H-Index: 50
#2Phyllis H. Raquinio (UH: University of Hawaii)H-Index: 1
Last. Meredith A. J. Hullar (Fred Hutchinson Cancer Research Center)H-Index: 11
view all 9 authors...