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Lisa Menegazzo
University of Padua
EndocrinologyProgenitor cellStem cellDiabetes mellitusMedicine
29Publications
18H-index
1,243Citations
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Publications 31
Newest
#1Serena Tedesco (UNIPD: University of Padua)H-Index: 6
#2Stefano CiciliotH-Index: 19
Last. Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
view all 10 authors...
Mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M (OSM) produced by M1 macrophages in the diabetic BM signals through p66Shc to induce Cxcl12 in stromal cells and retain HSPCs. BM adipocytes are another source of CXCL12 that blunts mobilization. We tested a strategy of pharmacologic macrophage reprogramming to rescue HSPC mobilization. In vitro, PPAR-gamma activation with pioglitazone switched macrophages from M1 to...
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#1Roberta Cappellari (UNIPD: University of Padua)H-Index: 14
#2Marianna D’Anna (UNIPD: University of Padua)H-Index: 4
Last. Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
view all 7 authors...
AIMS/HYPOTHESIS: Cardiovascular risk in diabetes is at least in part attributable to defective angiogenesis. Since diabetes negatively affects blood cells involved in angiogenesis, we herein evaluated whether diabetes impairs proangiogenic granulocytes (PAGs). METHODS: We characterised and quantified PAGs as CD49d(+) granulocytes in peripheral blood of participants with type 2 or type 1 diabetes and in non-diabetic control participants. We evaluated PAG antigenic profile and assessed in vitro fu...
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#1Mattia Albiero (UNIPD: University of Padua)H-Index: 27
#2Stefano CiciliotH-Index: 19
Last. Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
view all 13 authors...
Diabetes impairs the mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM), which can worsen the outcomes of HSPC transplantation and of diabetic complications. In this study, we examined the oncostatin M (OSM)–p66Shc pathway as a mechanistic link between HSPC mobilopathy and excessive myelopoiesis. We found that streptozotocin-induced diabetes in mice skewed hematopoiesis toward the myeloid lineage via hematopoietic-intrinsic p66Shc. The overexpression of Osm res...
5 CitationsSource
#1Lisa Menegazzo (UNIPD: University of Padua)H-Index: 18
#2Valentina Scattolini (UNIPD: University of Padua)H-Index: 6
Last. Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
view all 11 authors...
Aims Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.
8 CitationsSource
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Lisa Menegazzo (UNIPD: University of Padua)H-Index: 18
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 68
view all 17 authors...
Upon activation, neutrophils undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as neutrophil extracellular traps (NETs), and death. In diabetes, neutrophils are primed to release NETs and die by NETosis. Although this process is a defense against infection, NETosis can damage tissue. Therefore, we examined the effect of NETosis on the healing of diabetic foot ulcers (DFUs). Using proteomics, we found that NET components were enriched in nonh...
66 CitationsSource
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Benedetta Maria Bonora (UNIPD: University of Padua)H-Index: 10
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 68
view all 9 authors...
Context: Circulating cells, including endothelial progenitor cells (EPCs) and monocyte subtypes, are involved in diabetic complications. Modulation of these cells may mediate additional benefits of glucose-lowering medications. Objective: We assessed whether the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin acutely modifies EPCs and monocyte subsets in patients with type 2 diabetes. Design: This was a randomized, crossover, placebo-controlled trial. Setting: The study was conducted at a t...
33 CitationsSource
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Lisa Menegazzo (UNIPD: University of Padua)H-Index: 18
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 68
view all 6 authors...
Abstract Aims To review the significance of a new type of neutrophil cell death (NETosis) in diabetes and cardiometabolic diseases. Data synthesis Diabetes and the metabolic syndrome are characterized by activation of the innate immune system. In this framework, neutrophils are front line defences against infections, but can also turn deleterious if abnormally stimulated. NETosis refers to a type of cell death whereby neutrophils release nuclear material and granule enzymes that together form th...
17 CitationsSource
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Mark A. Fiala (WashU: Washington University in St. Louis)H-Index: 13
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 68
view all 11 authors...
Previous studies suggest that diabetes impairs hematopoietic stem cell (HSC) mobilization in response to granulocyte colony-stimulating factor (G-CSF). In this study, we tested whether the CXCR4 antagonist plerixafor, differently from G-CSF, is effective in mobilizing HSCs in patients with diabetes. In a prospective study, individuals with and without diabetes (n = 10/group) were administered plerixafor to compare CD34+ HSC mobilization; plerixafor was equally able to mobilize CD34+ HSCs in the ...
28 CitationsSource
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Lisa Menegazzo (UNIPD: University of Padua)H-Index: 18
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 68
view all 7 authors...
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β superfamily, has been recently described as a soluble rejuvenation factor for the heart, muscle, and brain. In fact, GDF11 declines in aged mice, while its replenishment improves vascular, brain, muscle, and cardiac function (1–3). As type 2 diabetes (T2D) increases with age and is characterized by accelerated aging (4), we cross-sectionally explored the effects of age, diabetes, and vascular disease on plasma...
3 CitationsSource
#1Lisa Menegazzo (UNIPD: University of Padua)H-Index: 18
#2Nicol Poncina (UNIPD: University of Padua)H-Index: 11
Last. Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
view all 7 authors...
Abstract Background and aims Diabetes is traditionally associated with vascular calcification, but the molecular mechanisms are largely unknown. We herein explored the relationships among carotid plaque calcification, composition and gene expression, and how these are modified by diabetes. Methods We collected carotid endoarterectomy specimen from 59 patients, of whom 23 had diabetes. We analysed histology with pentachromic staining, calcification with Alizarin red and Von Kossa's staining, chem...
7 CitationsSource
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