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Josh V. Vermaas
National Renewable Energy Laboratory
34Publications
10H-index
279Citations
Publications 36
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#1Josh V. VermaasH-Index: 10
#2Riin KontH-Index: 4
Last.Brandon C. KnottH-Index: 12
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#1Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
#2Michael F. Crowley (NREL: National Renewable Energy Laboratory)H-Index: 36
Last.Gregg T. Beckham (NREL: National Renewable Energy Laboratory)H-Index: 50
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Lignin and cellulose are two of the most abundant polymers on Earth, and are found in close proximity within plant cell walls. Despite their ubiquity, relatively little is known quantitatively about their interactions within plants, and by extension how their interaction may affect industrial biomass utilization. Given the inherent heterogeneity of the lignin polymer and the structural complexity of cellulose, quantitative relationships between given cellulose faces and specific lignin chemistri...
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#1Michael Julian Orella (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Terry Z. H. Gani (MIT: Massachusetts Institute of Technology)H-Index: 5
Last.Yuriy Román-Leshkov (MIT: Massachusetts Institute of Technology)H-Index: 35
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Lignin is an abundant biopolymer of phenylpropanoid monomers that is critical for plant structure and function. Based on the abundance of lignin in the biosphere and interest in lignin valorization, a more comprehensive understanding of lignin biosynthesis is imperative. Here we present an open-source software toolkit, Lignin-KMC, that combines kinetic Monte Carlo and first-principles calculations of radical coupling events, which enables modeling of lignin biosynthesis in silico. Lignification ...
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#1Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
#2Richard A. Dixon (UNT: University of North Texas)H-Index: 120
Last.Gregg T. Beckham (NREL: National Renewable Energy Laboratory)H-Index: 50
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Lignin is an abundant aromatic polymer found in plant secondary cell walls. In recent years, lignin has attracted renewed interest as a feedstock for bio-based chemicals via catalytic and biological approaches and has emerged as a target for genetic engineering to improve lignocellulose digestibility by altering its composition. In lignin biosynthesis and microbial conversion, small phenolic lignin precursors or degradation products cross membrane bilayers through an unidentified translocation m...
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Cellulase enzymes deconstruct recalcitrant cellulose into soluble sugars, making them a biocatalyst of biotechnological interest for use in the nascent lignocellulosic bioeconomy. Cellobiohydrolases (CBHs) are cellulases capable of liberating many sugar molecules in a processive manner without dissociating from the substrate. Within the complete processive cycle of CBHs, dissociation from the cellulose substrate is rate limiting, but the molecular mechanism of this step is unknown. Here, we pres...
1 CitationsSource
#1Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
#2Lauren D. Dellon (NU: Northwestern University)H-Index: 2
Last.Michael F. Crowley (NREL: National Renewable Energy Laboratory)H-Index: 36
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Lignin is an abundant aromatic heteropolymer found in secondary plant cell walls and is a potential feedstock for conversion into bioderived fuels and chemicals. Lignin chemical diversity complicates traditional structural studies, and so, relatively little experimental evidence exists for how lignin structure exists in aqueous solution or how lignin polymers respond to changes in their chemical environment. Molecular modeling can address these concerns; however, prior computational structural l...
2 CitationsSource
#1Josh V. VermaasH-Index: 10
#2Gregg T. BeckhamH-Index: 50
Last.Michael F. CrowleyH-Index: 36
view all 3 authors...
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#1Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
#2Loukas Petridis (ORNL: Oak Ridge National Laboratory)H-Index: 17
Last.Gregg T. Beckham (NREL: National Renewable Energy Laboratory)H-Index: 50
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Lignin is an abundant aromatic biopolymer within plant cell walls formed through radical coupling chemistry, whose composition and topology can vary greatly depending on the biomass source. Computational modeling provides a complementary approach to traditional experimental techniques to probe lignin interactions, lignin structure, and lignin material properties. However, current modeling approaches are limited based on the subset of lignin chemistries covered by existing lignin force fields. To...
1 CitationsSource
#1Fei Zheng (UMN: University of Minnesota)H-Index: 5
#2Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
Last.Huiying LuoH-Index: 33
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Cellulases from glycoside hydrolase (GH) family 5 are key endoglucanase enzymes in the degradation of diverse polysaccharide substrates and are used in industrial enzyme cocktails to break down biomass. The GH5 family shares a canonical (βα) 8 -barrel structure, where each (βα) module is essential for the enzyme stability and activity. Despite their shared topology, the thermostability of GH5 endoglucanase enzymes can vary significantly, and highly thermostable variants are often sought for indu...
2 CitationsSource
#1Fei Zheng (UMN: University of Minnesota)H-Index: 5
#2Josh V. Vermaas (NREL: National Renewable Energy Laboratory)H-Index: 10
Last.Huiying LuoH-Index: 33
view all 10 authors...
ABSTRACT Cellulases from glycoside hydrolase family 5 (GH5) are key endoglucanase enzymes in the degradation of diverse polysaccharide substrates and are used in industrial enzyme cocktails to break down biomass. The GH5 family shares a canonical (βα)8-barrel structure, where each (βα) module is essential for the enzyme’s stability and activity. Despite their shared topology, the thermostability of GH5 endoglucanase enzymes can vary significantly, and highly thermostable variants are often sough...
1 CitationsSource
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