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Bruno Giardina
Catholic University of the Sacred Heart
ChemistryHemoglobinOxygenBiochemistryBiology
495Publications
49H-index
9,622Citations
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Publications 522
Newest
#1Francesco Ria (UCSC: Catholic University of the Sacred Heart)H-Index: 20
#2Davide PirolliH-Index: 9
Last. Maria Cristina De RosaH-Index: 17
view all 10 authors...
Autoreactive T cells specific to human collagen type II have a crucial role in the development of rheumatoid arthritis (RA) in the context of MHC class II allele HLA-DRB1-*04. The protein–protein interactions between the T cell receptor (TCR) and the type II collagen bound to the allele MHC of class II may thus represent the target for the development of new drugs against RA. In this study, a structure-based pharmacophore model for potential small molecule inhibitors was developed from protein–p...
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#1Francesca SciandraH-Index: 13
#2Bianca Maria Scicchitano (UCSC: Catholic University of the Sacred Heart)H-Index: 4
Last. Andrea Brancaccio (UoB: University of Bristol)H-Index: 28
view all 11 authors...
Dystroglycan (DG) is an adhesion complex formed by two subunits, α-DG and β-DG. In skeletal muscle, DG is part of the dystrophin-glycoprotein complex that is crucial for sarcolemma stability and it is involved in a plethora of muscular dystrophy phenotypes. Due to the important role played by DG in skeletal muscle stability as well as in a wide variety of other tissues including brain and the peripheral nervous system, it is essential to investigate its genetic assembly and transcriptional regul...
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Last. Bruno GiardinaH-Index: 49
view all 3 authors...
Background: In this study, human neuroblastoma cells (IMR32) treated with Amyloid Beta Peptide (APβ), were used as model to evaluate the molecular basis of protective role of S100b, a neurotrophic factor and neuronal survival protein, highly expressed by reactive astrocytes close to amyloid deposition in the cortex of Alzheimer's patients. The aim of this work is to value the effect of S100b on ROS production in cells treated with Amyloid Beta Peptide and the subsequent influence on globin gene ...
3 CitationsSource
#1Silvana FicarraH-Index: 15
#2Ester TelloneH-Index: 16
Last. Maria Cristina De Rosa (UCSC: Catholic University of the Sacred Heart)H-Index: 17
view all 10 authors...
Resveratrol is widely known as an antioxidant and anti-inflammatory molecule. The present study first reports the effects of trans-δ-viniferin (TVN), a dimer of resveratrol, on human erythrocytes. The antioxidant activity of TVN was tested using in vitro model systems such as hydroxy radical scavenging, DPPH and lipid peroxidation. In addition we have examined the influence of the 15R,22R- and 15S,22S-enantiomers (abbreviated R,R-TVN, and S,S-TVN, respectively) on anion transport, ATP release, c...
8 CitationsSource
#1Maria Elisabetta Clementi (CUA: The Catholic University of America)H-Index: 4
#2Giuseppe Tringali (CUA: The Catholic University of America)H-Index: 22
Last. Bruno Giardina (CUA: The Catholic University of America)H-Index: 49
view all 4 authors...
Abstract Aloe arborescens is commonly used as a pharmaceutical ingredient for its effect in burn treatment and ability to increase skin wound healing properties. Besides, it is well known to have beneficial phytotherapeutic, anticancer, and radio-protective properties. In this study, we first provided evidence that A. arborescens extract protects IMR32, a neuroblastoma human cellular line, from toxicity induced by beta amyloid, the peptide responsible for Alzheimer's disease. In particular, pret...
8 CitationsSource
#1Ester Tellone (UNIME: University of Messina)H-Index: 16
#2Annamaria RussoH-Index: 12
Last. Silvana FicarraH-Index: 15
view all 5 authors...
This comparative study, focused on the anion kinetic of band 3 protein of pig erythrocytes, investigates in vitro the metabolic functionality of the red blood cells of this mammal which show particular characteristics of the cell membrane and significant s...
1 CitationsSource
#1Francesca Sciandra (CUA: The Catholic University of America)H-Index: 13
Last. Andrea Brancaccio (CUA: The Catholic University of America)H-Index: 28
view all 5 authors...
In skeletal muscle, dystroglycan (DG) is the central component of the dystrophin-glycoprotein complex (DGC), a multimeric protein complex that ensures a strong mechanical link between the extracellular matrix and the cytoskeleton. Several muscular dystrophies arise from mutations hitting most of the components of the DGC. Mutations within the DG gene (DAG1) have been recently associated with two forms of muscular dystrophy, one displaying a milder and one a more severe phenotype. This review foc...
4 CitationsSource
#1Ester Tellone (UNIME: University of Messina)H-Index: 16
#2Antonio Galtieri (UNIME: University of Messina)H-Index: 18
Last. Silvana Ficarra (UNIME: University of Messina)H-Index: 15
view all 5 authors...
Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, A...
55 CitationsSource
#1Cristiana Carelli-Alinovi (CUA: The Catholic University of America)H-Index: 4
#2Bruno Giardina (CUA: The Catholic University of America)H-Index: 49
Last. Francesco Misiti (University of Cassino)H-Index: 20
view all 3 authors...
Glycolysis and pentose phosphate pathway (PPP) in red blood cell (RBC) are modulated by the cell oxygenation state. This metabolic modulation is connected to variations in intracellular nicotinamide adenine dinucleotide phosphate-reduced form (NADPH) and adenosine triphosphate (ATP) levels as a function of the oxygenation state of the cell, and, consequently, it should have physiologic relevance. In the present study, we analysed the effects of amyloid beta peptide (1–42) (Abeta) on RBC metaboli...
7 CitationsSource
#2Davide PirolliH-Index: 9
Last. Francesco Misiti (University of Cassino)H-Index: 20
view all 4 authors...
We have previously showed that morphological alterations in Red Blood Cells (RBCs) are correlated to an impaired eNOS enzymatic activity and a concomitant reduced NO derived metabolites formation. Here we extend our previous obser- vations, reporting that RBC morphology is regulated by a series of specific cell signaling events linked to Protein Kinase C (PKC)-mediated activation of caspase 3. Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristat...
4 CitationsSource
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