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Paola Sebastiani
Boston University
277Publications
46H-index
7,828Citations
Publications 287
Newest
The emergence of large-scale multi-omics data warrants method development for data integration. Genomic studies from cancer patients have identified epigenetic and genetic regulators – such as methylation marks, somatic mutations, and somatic copy number alterations (SCNAs), among others – as predictive features of cancer outcome. However, identification of “driver genes” associated with a given alteration remains a challenge. To this end, we developed a computational tool, iEDGE, to model cis a...
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#1Joris Deelen (MPG: Max Planck Society)H-Index: 33
#2Daniel S. Evans (CPMC: California Pacific Medical Center)H-Index: 21
Last.Joanne M. Murabito (BU: Boston University)H-Index: 75
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Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipopr...
1 CitationsSource
#1Kenneth Westerman (Tufts University)H-Index: 3
#2Paola Sebastiani (BU: Boston University)H-Index: 46
Last.José María Ordovás Muñoz (IMDEA)H-Index: 109
view all 6 authors...
Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci. Here, we undertook module- and region-based DNA methylation analyses of incident CVD in the Women’s Health Initiative (WHI) and Framingham Heart Study Offspring Cohort (FHS...
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