Elena Gallon
University of Padua
MicelleOrganic chemistryChemistryConjugatePolymersome
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Publications 9
#1Inmaculada Conejos-Sánchez (University of Cambridge)H-Index: 3
#2Elena GallonH-Index: 5
Last. María J. VicentH-Index: 33
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Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimolecular delivery vehicles are concentrated on overcoming the difficulties in delivery of small interfering (si)RNA to target tissues, which include anatomical accessibility, slow diffusion, safety concerns, and the requirement for specific cell uptake within the unique...
#1Hoay Yan CheahH-Index: 3
#2Elena GallonH-Index: 5
Last. Lik Voon KiewH-Index: 11
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We previously developed a new zinc(II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity, and nonselectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near-infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environme...
2 CitationsSource
#1Liane I.F. Moura (University of Lisbon)H-Index: 11
#2Aroa Duro-CastanoH-Index: 6
Last. Helena F. Florindo (University of Lisbon)H-Index: 15
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Introduction Melanoma is the most dangerous type of skin cancer and novel treatments are needed. Alternative therapeutics should be devised isolated or in combination with targeted immunotherapies, to efficiently stimulate specific anti-tumour responses. Branched polypeptides exhibit advanced engineered complexity and unique structural properties inaccessible to linear polymers that make them ideal drug delivery systems with enhanced biological performance. Branched nanosystems have the ability ...
#1Aroa Duro-CastanoH-Index: 6
#2Elena GallonH-Index: 5
Last. María J. VicentH-Index: 33
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Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, has become an attractive strategy for the development of efficient guided nanomedicines. In this respect, integrins are cell-adhesion molecules involved in angiogenesis signaling pathways and are overexpressed in many angiogenic processes. Therefore, they represent specific biomarkers not only to monitor disease progression but also to rationally design targeted nanomedicines. Arginine-glycine-aspar...
13 CitationsSource
#1Lik Voon Kiew (UM: University of Malaya)H-Index: 11
#2Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract In photodynamic therapy (PDT), the low absorptivity of photosensitizers in an aqueous environment reduces singlet oxygen generation efficiency and thereby decreases photosensitizing efficacy in biological conditions. To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate ( 1-PG ) made from a new phthalocyanine ( Pc 1 ) monofunctionalized to allow adequate conjugation to PGA. The resulting 1-PG conjugate retained high absorptivity in the near-infrared (NI...
7 CitationsSource
#1Elena Gallon (National Research Council)H-Index: 5
#2Teresa Matini (University of Nottingham)H-Index: 3
Last. Stefano Salmaso (National Research Council)H-Index: 25
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New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weakly basic block, polyimidazole-hexyl methacrylate (poly-ImHeMA), which can complex with oligonucleotides and control vesicle formation/disassembly via pH variations. Targeted polymersomes were prepared by mixing folate-derivatized and underivatized co...
19 CitationsSource
#1Teresa Matini (University of Nottingham)H-Index: 3
#2Nora Francini (UNIPD: University of Padua)H-Index: 4
Last. Cameron Alexander (University of Nottingham)H-Index: 41
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Responsive materials that change conformation with varying pH have been prepared from a range of amphiphilic block co-polymers. The individual blocks are composed of (a) permanently hydrophilic chains with neutral functionality and (b) acrylate polymers with weakly basic side-chains. Variation in co-monomer content, molar mass and block ratios/compositions leads to a range of pH-responses, manifest through reversible self-assembly into micelles and/or polymersomes. These transitions can be tuned...
13 CitationsSource
#1Elena Ravazzolo (UNIPD: University of Padua)H-Index: 2
#2Stefano Salmaso (UNIPD: University of Padua)H-Index: 25
Last. Paolo Caliceti (UNIPD: University of Padua)H-Index: 42
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Abstract A new acid-sensitive drug-delivery nanocarrier has been developed for tumour targeting. The self-assembling co-polymer stearoyl–PEG–poly-sulfadimethoxine methacrylate (stearoyl–PEG–polySDM) was prepared to obtain micelles with responsive behaviour in the physiopathologic pH range. Stearoyl–PEG–polySDM was synthesised using a multi-step procedure that includes pH-sensitive sulfadimethoxine methacrylate polymerisation by AGET-ATRP at the amino terminal side of stearoyl–PEG–NH 2 . Chemical...
11 CitationsSource
#1Teresa MatiniH-Index: 3
#2Cameron AlexanderH-Index: 41
Last. María J. VicentH-Index: 33
view all 10 authors...