John T. Farrar
VCU Medical Center
Publications 290
Abstract The estimated probability of progressing from phase 3 analgesic clinical trials to regulatory approval is approximately 57%, suggesting that a considerable number of treatments with phase 2 trial results deemed sufficiently successful to progress to phase 3 do not yield positive phase 3 results. Deficiencies in the quality of clinical trial conduct could account for some of this failure. An Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) meeting was ...
#1Gregory T. Kennedy (UPenn: University of Pennsylvania)H-Index: 4
#2Christine Hill (UPenn: University of Pennsylvania)H-Index: 11
Last.Julia Tchou (UPenn: University of Pennsylvania)H-Index: 29
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Abstract Introduction Enhanced Recovery after Surgery (ERAS) protocols have contributed to shortened hospital stays and reduced narcotic use after common surgical procedures. Though ERAS protocols exist for breast surgery, they have not been studied for implant-based reconstruction after mastectomy. Methods Twenty-three consecutive patients undergoing mastectomy with implant-based reconstruction were treated with perioperative gabapentin, acetaminophen, and NSAIDs. Data regarding clinical course...
1 CitationsSource
#1Martin SchmelzH-Index: 72
#2Patrick W. MantyhH-Index: 84
Last.Lars ViktrupH-Index: 29
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AbstractChronic pain continues to be a significant global burden despite the availability of a variety of nonpharmacologic and pharmacologic treatment options. Thus, there is a need for new analgesics with novel mechanisms of action. In this regard, antibodies directed against nerve growth factor (N
#1Anita A. Kohli (Yale University)H-Index: 1
#2Arastoo Vossough (Children's Hospital of Philadelphia)H-Index: 20
Last.Christina L. Szperka (Children's Hospital of Philadelphia)H-Index: 4
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Abstract Background Revised diagnostic criteria for pseudotumor cerebri syndrome require three of four neuroimaging findings in the absence of papilledema. We examined the sensitivity and specificity of three or more of four of these magnetic resonance imaging (MRI) findings for pseudotumor cerebri syndrome in children. Methods As part of clinical care, patients in whom there was suspicion for pseudotumor cerebri syndrome underwent neurological and fundoscopic examinations, lumbar puncture, MRI,...
1 CitationsSource
Background No studies have examined the long-term benefits of regional anesthesia (RA) for pain management after combat-related injury. The objective of this prospective cohort study was to examine the relationship between RA administration and patient-reported pain-related outcomes among Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) service members sustaining a combat-related extremity injury. Methods Between 2007 and 2013, n=358 American military personnel injured in OEF/O...
#1Katherine N. Theken (UPenn: University of Pennsylvania)H-Index: 9
#2Elliot V. Hersh (UPenn: University of Pennsylvania)H-Index: 28
Last.John T. Farrar (UPenn: University of Pennsylvania)H-Index: 61
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#1Gunnar Tomasson (University of Iceland)H-Index: 14
#2John T. FarrarH-Index: 61
Last.Peter A. MerkelH-Index: 67
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OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CA...
#1Rony R Sayegh (Case Western Reserve University)
#2Maureen G. Maguire (UPenn: University of Pennsylvania)H-Index: 58
Last.Penny A. Asbell (UTHSC: University of Tennessee Health Science Center)H-Index: 36
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#1Jennifer S. Gewandter (UR: University of Rochester)H-Index: 18
#2Michael P. McDermott (UR: University of Rochester)H-Index: 79
Last.Robert H. Dworkin (UR: University of Rochester)H-Index: 74
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1 CitationsSource