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William Coryell
University of Iowa Hospitals and Clinics
Publications 424
Published in JAMA 51.27
William Coryell85
Estimated H-index: 85
(UI: University of Iowa)
Published on May 27, 2019in Suicide and Life Threatening Behavior 3.03
William Coryell85
Estimated H-index: 85
(Roy J. and Lucille A. Carver College of Medicine),
Jess G. Fiedorowicz26
Estimated H-index: 26
(Roy J. and Lucille A. Carver College of Medicine)
+ 2 AuthorsMartin B. Keller116
Estimated H-index: 116
(Brown University)
Published on May 1, 2019in Nature Genetics 25.45
Eli A. Stahl48
Estimated H-index: 48
(ISMMS: Icahn School of Medicine at Mount Sinai),
Gerome Breen53
Estimated H-index: 53
('KCL': King's College London)
+ 274 AuthorsHéléna A. Gaspar14
Estimated H-index: 14
('KCL': King's College London)
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10−4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10−8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but al...
Published on Apr 8, 2019
David A. Solomon43
Estimated H-index: 43
Andrew C. Leon70
Estimated H-index: 70
+ 5 AuthorsMartin B. Keller116
Estimated H-index: 116
Published on Mar 1, 2019in Journal of Affective Disorders 4.08
Jess G. Fiedorowicz26
Estimated H-index: 26
(UI: University of Iowa),
Jane E. Persons6
Estimated H-index: 6
(Roy J. and Lucille A. Carver College of Medicine)
+ 6 AuthorsWilliam Coryell85
Estimated H-index: 85
(Roy J. and Lucille A. Carver College of Medicine)
A bstract Objectives To determine whether the risk of suicidal ideation or behavior during mixed states exceeds that attributable to the depressive components of these states alone in bipolar disorder. Methods We utilized real-world, longitudinal clinical data collected on 290 patients with bipolar disorders (bipolar I, bipolar II, and bipolar not otherwise specified (NOS)) from the National Network of Depression Centers (NNDC) Clinical Care Registry (CCR) seen for 891 visits over a mean of 27.5...
Published on Feb 1, 2019in Neuropsychopharmacology 7.16
Michael McCarthy29
Estimated H-index: 29
(UCSD: University of California, San Diego),
Heather Wei3
Estimated H-index: 3
+ 59 AuthorsAmit Anand34
Estimated H-index: 34
(IU: Indiana University Bloomington)
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (...
Published on Jan 1, 2019in European Neuropsychopharmacology 4.47
Monika Budde7
Estimated H-index: 7
(LMU: Ludwig Maximilian University of Munich),
Stefanie Friedrichs3
Estimated H-index: 3
(GAU: University of Göttingen)
+ 57 AuthorsAshley L. Comes2
Estimated H-index: 2
(LMU: Ludwig Maximilian University of Munich)
Abstract Genome-wide association studies of case-control status have advanced the understanding of the genetic basis of psychiatric disorders. Further progress may be gained by increasing sample size but also by new analysis strategies that advance the exploitation of existing data, especially for clinically important quantitative phenotypes. The f unctionally- i nformed e fficient r egion-based test s trategy (FIERS) introduced herein uses prior knowledge on biological function and dependence o...
Published on Dec 1, 2018in Nature Communications 11.88
Robert Maier8
Estimated H-index: 8
(Broad Institute),
Zhihong Zhu18
Estimated H-index: 18
(UQ: University of Queensland)
+ 238 AuthorsPeter M. Visscher100
Estimated H-index: 100
(UQ: University of Queensland)
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published genome-wide association study (GWAS) summary statistics across many different traits....
René Breuer28
Estimated H-index: 28
(Heidelberg University),
Manuel Mattheisen47
Estimated H-index: 47
(University of Würzburg)
+ 49 AuthorsFranziska Degenhardt30
Estimated H-index: 30
(University of Bonn)
Background Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in explaining the high heritability of BD through GWAS have remained elusive. To overcome this dilemma, genetic research into BD, has embraced a variety of strategies such as the formation of large consortia to increase sample size and seque...