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Dorota Wrześniok
Medical University of Silesia
57Publications
13H-index
430Citations
Publications 62
Newest
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
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Cobalamin deficiency is an important health problem. The major non-hematological symptoms of hypocobalaminemia are nervous system disorders, but the molecular and cellular mechanisms underlying this phenomenon have not yet been fully explained. Increasing scientific evidence is stressing the pivotal role of astrocyte dysfunction in the pathogenesis of a wide range of neurological disorders. In light of the above, the aim of this study was to develop an in vitro model of cobalamin deficiency by o...
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#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 protein in melanoma cells is associated with rapid tumor progression, poor prognosis and low chemosensitivity. Therefore, the antiapoptotic protein Mcl-1 could be considered as a potential target for malignant melanoma treatment. The aim of this study was to assess the effect of MIM1 a specific low molecular Mcl-1 protein inhibitor and mixture...
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#1Jakub Rok (Medical University of Silesia)H-Index: 7
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
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Abstract Tetracyclines belong to antimicrobial classes with the highest consumption in veterinary medicine and agriculture, which leads to the contamination of the environment and food products, as well as to antibiotic resistance and adverse drug reactions. Chloro-derivatives of tetracyclines are thought to be relatively more phototoxic than others and belong to the most frequently cited drugs as photosensitizers. Melanins are heterogenous biopolymers determining skin, hair and eye colour. They...
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#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 6 authors...
Abstract Fluoroquinolones were shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The aim of the present study was to examine the effect of moxifloxacin on cell viability, redox balance and apoptosis in both amelanotic – C32 and melanotic – COLO829 melanoma cells. Herein, we found that moxifloxacin decreases the viability of C32 and COLO829 cells in concentration- and time-dependent manner. The EC50 values were foun...
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#1Dorota WrześniokH-Index: 13
view all 5 authors...
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