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Emmerik F. A. Leijten
Utrecht University
Physical therapyImmunologyPsoriatic arthritisInnate lymphoid cellMedicine
14Publications
4H-index
99Citations
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Publications 22
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Background: Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) are the first-line treatment for psoriatic arthritis (PsA), but there is conflicting data regarding their efficacy and scarce reports describing the duration of use (drug retention) of csDMARD in this population. Their position in treatment recommendations is a matter of growing debate due the availability of alternative treatment options with higher levels of evidence. Objectives: To study drug retention and pr...
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#1Tessa S. van Kempen (UU: Utrecht University)H-Index: 3
#2Emmerik F. A. Leijten (UU: Utrecht University)H-Index: 4
Last. Marianne Boes (UU: Utrecht University)H-Index: 37
view all 10 authors...
Ankylosing spondylitis (AS) is associated with autoantibody production to Class II MHC-associated invariant chain peptide, CD74/CLIP. In this study, we considered that anti-CD74/CLIP autoantibodies present in sera from AS might recognize CD74 degradation products that accumulate upon deficiency of the enzyme signal peptide peptidase-like 2A (SPPL2a). We analyzed monocytes from healthy controls (n = 42), psoriatic arthritis (n = 25), rheumatoid arthritis (n = 16) and AS patients (n = 15) for SPPL...
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#1Juliëtte Pouw (UU: Utrecht University)H-Index: 2
#2Emmerik F. A. Leijten (UU: Utrecht University)H-Index: 4
Last. Marianne Boes (UU: Utrecht University)H-Index: 37
view all 4 authors...
Abstract Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory musculoskeletal disorder that affects ~0.1% of the population. PsA may severely impact quality-of-life and constitutes a significant economic burden on our health care system. While early effective treatment is deemed essential to prevent irreversible joint damage and functional impairment, not all patients respond to the same disease modifying anti-rheumatic drugs (DMARDs). DMARD options for PsA are rapidly evolving, ye...
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#1Kamil G. Laban (UU: Utrecht University)H-Index: 4
#2Rachel Kalmann (UU: Utrecht University)H-Index: 10
Last. Jonas J. W. Kuiper (UU: Utrecht University)H-Index: 11
view all 15 authors...
Non-Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology that can be difficult to diagnose. In this study we aim to identify serum miRNAs associated with NHOL and IOI. We performed OpenArray® miRNA profiling in 33 patients and controls. Differentially expressed miRNAs were technically validated across technology platforms and replicated in an additional cohort of 32 patients and controls. We identified and in...
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#1Sofie L. M. Blokland (UU: Utrecht University)H-Index: 6
#2Lucas L. van den Hoogen (UU: Utrecht University)H-Index: 6
Last. Timothy R. D. J. Radstake (UU: Utrecht University)H-Index: 55
view all 8 authors...
OBJECTIVE: The role of innate lymphoid cells (ILCs) in the pathophysiology of rheumatic diseases is emerging. Evidence from animal studies implicate type I IFN, produced by plasmacytoid dendritic cells, to be involved in regulating the survival of group 2 and group 3 ILCs (ILC2s and ILC3s) via the upregulation of Fas (CD95) expression. For the first time, we explored the frequency and phenotype of circulating ILCs in SLE and primary Sjogren's syndrome (pSS) in relationship to the IFN signature. ...
1 CitationsSource
#1Kamil G. LabanH-Index: 4
#2Rachel KalmannH-Index: 10
Last. Jonas J. W. KuiperH-Index: 11
view all 15 authors...
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Psoriasis is a common immune-mediated inflammatory condition that primarily affects skin and nails. 6-41% of psoriasis patients develop psoriatic arthritis (PsA). The ways in which PsA can manifest itself include peripheral arthritis, axial spondyloarthritis, dactylitis and enthesitis. This heterogeneous clinical picture makes it sometimes difficult to recognise PsA,potentially resulting in permanent joint damage and functional impairments. Some people see psoriasis and PsA as 2 manifestations o...
Psoriasis is a common immune-mediated inflammatory condition that primarily affects skin and nails. 6-41% of psoriasis patients develop psoriatic arthritis (PsA). The ways in which PsA can manifest itself include peripheral arthritis, axial spondyloarthritis, dactylitis and enthesitis. This heterogeneous clinical picture makes it sometimes difficult to recognise PsA,potentially resulting in permanent joint damage and functional impairments. Some people see psoriasis and PsA as 2 manifestations o...
#1Nienke J. Kleinrensink (UU: Utrecht University)H-Index: 2
#2Emmerik F. A. Leijten (UU: Utrecht University)H-Index: 4
Last. Timothy R. D. J. Radstake (UU: Utrecht University)H-Index: 55
view all 7 authors...
Background Enthesitis is thought to be a key feature driving the development of spondyloarthritis, although head-to-head studies in patients with psoriasis (Pso) versus psoriatic arthritis (PsA) are scarce. In PsA and ankylosing spondylitis (AS) patients the plantar fascia and Achilles tendon are among the entheseal structures most frequently affected clinically. MRI allows for objective detection of enthesitis in patients with rheumatic diseases. Objectives To assess the frequency of MRI-detect...
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