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Jeffrey N. Weitzel
City of Hope National Medical Center
314Publications
49H-index
11.6kCitations
Publications 314
Newest
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Joe Dennis (University of Cambridge)H-Index: 37
view all 333 authors...
#1Joshua D. Hoffman (UCSF: University of California, San Francisco)H-Index: 8
#2Laura Fejerman (UCSF: University of California, San Francisco)H-Index: 16
Last.Jeffrey N. Weitzel (City of Hope National Medical Center)H-Index: 49
view all 22 authors...
Background Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas.
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
view all 333 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Felipe Batalini (BIDMC: Beth Israel Deaconess Medical Center)
#2Ellie G. Peacock (BIDMC: Beth Israel Deaconess Medical Center)
Last.Nadine Tung (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 52
view all 7 authors...
The introduction of next-generation sequencing has resulted in testing multiple genes simultaneously to identify inherited pathogenic variants (PVs) in cancer susceptibility genes. PVs with low minor allele frequencies (MAFs) (< 25–35%) are highlighted on germline genetic test reports. In this review, we focus on the challenges of interpreting PVs with low MAF in breast cancer patients undergoing germline testing and the implications for management. The clinical implications of a germline PV are...
#1Shafat Ali (Beckman Research Institute)
#2Yilan Zhang (Beckman Research Institute)
Last.Binghui Shen (Beckman Research Institute)H-Index: 39
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Germline mutations of DNA double-strand break (DSB) response and repair genes that drive tumorigenesis could be a major cause of prostate cancer (PCa) heritability. In this study, we demonstrated the role of novel exonuclease 5 (EXO5) gene in androgen-induced double strand breaks repair via homology-directed repair pathway and prostate tumorigenesis. Using whole-exome sequencing of samples from 20 PCa families, with three or more siblings diagnosed with metastatic PCa, we identified mutations in...
#1Tara M. Friebel (Harvard University)H-Index: 20
#2Irene L. Andrulis (U of T: University of Toronto)H-Index: 75
Last.Patricia A. Ganz (UCLA: University of California, Los Angeles)H-Index: 97
view all 42 authors...
#1Yiwey Shieh (UCSF: University of California, San Francisco)H-Index: 7
#2Laura Fejerman (UCSF: University of California, San Francisco)H-Index: 16
Last.Mabel Bohorquez (Universidad del Tolima)H-Index: 7
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#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
Last.Manjeet K. Bolla (University of Cambridge)H-Index: 27
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Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...
#1Thomas P. Slavin (City of Hope National Medical Center)H-Index: 8
#2Can-Lan Sun (City of Hope National Medical Center)H-Index: 19
Last.Jeffrey N. Weitzel (City of Hope National Medical Center)H-Index: 49
view all 0 authors...
Abstract Objective Our goal was to identify pathogenic variants (PV) associated with germline cancer predisposition in an unselected cohort of older breast cancer survivors. Older patients with cancer may also be at higher risk for clonal hematopoiesis (CH) due to their age and chemotherapy exposure. Therefore, we also explored the prevalence of PVs suggestive of CH. Methods We evaluated 44 older adults (65 years or older) diagnosed with breast cancer who survived at least two years after diagno...
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