Dana Tomescu
Carol Davila University of Medicine and Pharmacy
SurgeryLiver transplantationAnesthesiaGeneral surgeryMedicine
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Publications 117
#1E. Weiss (Beaujon Hospital)H-Index: 3
#2Fuat H. SanerH-Index: 32
Last. Constantino Fondevila (University of Barcelona)H-Index: 30
view all 36 authors...
BACKGROUND Critically ill cirrhotic patients are increasingly transplanted, but there is no consensus about futile liver transplantation (LT).Therefore, the decision to delay or deny LT is often extensively debated. These debates arise from different opinions of futility among transplant team members. This study aims to achieve a multinational and multidisciplinary consensus on the definition of futility in LT and to develop well-articulated criteria for not proceeding with LT due to futility. M...
#1Dan G. DudaH-Index: 63
#2Simona DimaH-Index: 19
Last. Dana TomescuH-Index: 9
view all 14 authors...
Background: Improving surgical outcomes in hepatocellular carcinoma (HCC) patients would greatly benefit from biomarkers. Angiogenesis and inflammation are hallmarks of HCC progression and therapeutic targets. Methods: We retrospectively evaluated preoperative clinical variables and circulating (plasma) biomarkers of angiogenesis and inflammation in a cohort of HCC patients who underwent liver resection (LR) or transplantation (LT). Biomarker correlation with outcomes—freedom of liver recurrence...
: : Waiting for lab tests results for the calculation of disseminated intravascular coagulation (DIC) scores leads to unwanted delays in diagnosis. The use of rotational thromboelastometry (ROTEM) for this purpose would allow for a more rapid DIC diagnosis at the bedside. The aim of this study was to assess the ability of standard ROTEM parameters and calculated parameters from the ROTEM velocity curve to predict DIC. The retrospective observational study included 97 septic patients. Japanese As...
Recently, an increasing number of novel drugs were approved in oncology and hematology. Nevertheless, pharmacology progress comes with a variety of side effects, of which cytokine release syndrome (CRS) is a potential complication of some immunotherapies that can lead to multiorgan failure if not diagnosed and treated accordingly. CRS generally occurs with therapies that lead to highly activated T cells, like chimeric antigen receptor T cells or in the case of bispecific T-cell engaging antibodi...
1 CitationsSource
The purpose of Goal Directed Therapy (GDT) is to improve patient outcome by the optimization of hemodynamic status, as it is considered that many perioperative complications are related to microcirculatory disturbance due to an imbalance between oxygen delivery and consumption. The application of GDT protocols incorporating the assessment and optimization of patients' intravascular status should theoretically lead to a reduction in perioperative bleeding and transfusion requirements, as both hyp...
#1Fuat H. SanerH-Index: 32
#2Gianni BiancofioreH-Index: 22
Last. Dana TomescuH-Index: 9
view all 7 authors...
#2Liana VăleanuH-Index: 1
Last. Azriel PerelH-Index: 36
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BACKGROUND:Consecutive fluid challenges (FCs) are frequently administered to maximize the stroke volume (SV) as part of a goal-directed therapy (GDT) strategy. However, fluid administration may also cause acute hemodilution that might lead to an actual paradoxical decrease in oxygen delivery (DO2).
1 CitationsSource
#1Dana Tomescu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 9
#2Mihai Popescu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 4
Last. Gianni BiancofioreH-Index: 22
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Abstract Acute-on-chronic liver failure represents a newly defined entity in patients with liver disease leading to multiple organs failures and increased mortality. To date, no universally accepted definition exists, and different academic societies developed guidelines on the early diagnosis and classification of Acute-on-chronic liver failure. Recently published trials focused on factors associated with a poor outcome and on the development of severity scores aimed to identify patients who ma...
#2BraşoveanuH-Index: 3
Last. Irinel Popescu (Titu Maiorescu University)H-Index: 4
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BACKGROUND: The liver is one of the most frequently injured organs in abdominal trauma. The advancements in diagnosis and interventional therapy shifted the management of liver trauma towards a non-operative management (NOM). Nevertheless, in severe liver injuries (LI), surgical treatment often involving liver resection (LR) and rarely liver transplantation (LT) remains the main option. The present paper analyses a single center experience in a referral HPB center on a series of patients with hi...