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Olga Medina-Martinez
Baylor College of Medicine
12Publications
7H-index
260Citations
Publications 12
Newest
#1Shao Qing Kuang (University of Texas Health Science Center at Houston)H-Index: 7
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 23 authors...
The ascending thoracic aorta is designed to withstand biomechanical forces from pulsatile blood. Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of genetically triggered defects in aortic structure and a dysfunctional response to these forces. Here, we describe mutations in the forkhead transcription factor FOXE3 that predispose mutation-bearing individuals to TAAD. We performed exome sequencing of a large family with multiple members with TAADs and identified a ...
35 CitationsSource
#1Olga Medina-Martinez (BCM: Baylor College of Medicine)H-Index: 7
2 CitationsSource
#1Olga Medina-Martinez (BCM: Baylor College of Medicine)H-Index: 7
#2Rina Shah (BCM: Baylor College of Medicine)H-Index: 10
Last.Milan Jamrich (BCM: Baylor College of Medicine)H-Index: 30
view all 3 authors...
The transcription factor Pitx3 is critical for lens formation. Deletions in the promoter of this gene cause abnormal lens development in the aphakia (ak) mouse mutant, which has only rudimentary lenses. In this study, we investigated the role of Pitx3 in lens development and differentiation. We found that reduced expression of Pitx3 leads to changes in the proliferation, differentiation and survival of lens cells. The genetic interactions between Pitx3 and Foxe3 were investigated, as these two t...
32 CitationsSource
#1Milan Jamrich (BCM: Baylor College of Medicine)H-Index: 30
#2Olga Medina-Martinez (BCM: Baylor College of Medicine)H-Index: 7
Last.Richard R. Behringer (BCM: Baylor College of Medicine)H-Index: 33
view all 8 authors...
#1Olga Medina-Martinez (BCM: Baylor College of Medicine)H-Index: 7
#2Felipe Amaya-Manzanares (BCM: Baylor College of Medicine)H-Index: 4
Last.Milan Jamrich (BCM: Baylor College of Medicine)H-Index: 30
view all 9 authors...
Rx is a paired-like homeobox gene that is required for vertebrate eye formation. Mice lacking Rx function do not develop eyes or the posterior pituitary. To determine whether Rx is required cell autonomously in these tissues, we generated embryonic chimeras consisting of wild type and Rx−/− cells. We found that in the eye, Rx-deficient cells cannot participate in the formation of the neuroretina, retina pigment epithelium and the distal part of the optic stalk. In addition, in the ventral forebr...
31 CitationsSource
The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens. In this review, we highlight recent advances that have led to a better understanding ...
53 CitationsSource
#1Rina ShahH-Index: 10
Last.Milan Jamrich (TMC: Texas Medical Center)H-Index: 4
view all 5 authors...
Fox (forkhead) genes encode transcription factors that play important roles in the regulation of embryonic patterning as well as in tissue specific gene expression. Mutations in the human FOXP2 gene cause abnormal speech development. Here we report the structure and expression pattern of zebrafish FoxP2. In zebrafish, this gene is first expressed at the 20-somite stage in the presumptive telencephalon. At this stage there is a significant overlap of FoxP2 expression with the expression of the em...
23 CitationsSource
#1Olga Medina-Martinez (BCM: Baylor College of Medicine)H-Index: 7
#2Isaac Brownell (BCM: Baylor College of Medicine)H-Index: 4
Last.Milan Jamrich (BCM: Baylor College of Medicine)H-Index: 30
view all 6 authors...
During mouse eye development, the correct formation of the lens occurs as a result of reciprocal interactions between the neuroectoderm that forms the retina and surface ectoderm that forms the lens. Although many transcription factors required for early lens development have been identified, the mechanism and genetic interactions mediated by them remain poorly understood. Foxe3 encodes a winged helix-forkhead transcription factor that is initially expressed in the developing brain and in the le...
69 CitationsSource
#1Hasan Mahmud RezaH-Index: 16
#2Kunio YasudaH-Index: 38
Last.Rod BremnerH-Index: 29
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Source
#1Hsiu-Ting Tseng (BCM: Baylor College of Medicine)H-Index: 2
#2Isaac Brownell (BCM: Baylor College of Medicine)H-Index: 4
Last.Milan Jamrich (BCM: Baylor College of Medicine)H-Index: 30
view all 8 authors...
Fox genes encode a remarkably conserved family of nuclear proteins that can act as transcriptional activators or repressors. Their high level of conservation is probably due to the critical roles they play in embryonic pattern formation and tissue-specific gene expression (Dirksen and Jamrich 1992; Sasaki and Hogan 1993; Hatini et al. 1994; Dirksen and Jamrich 1995; Kaufmann and Knochel 1996; Martinez et al. 1997; Kenyon et al. 1999; Brownell et al. 2000; Carlsson and Mahlapuu 2002). Fox genes e...
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