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Slavimir Veljkovic
University of Niš
NephrotoxicityEndocrinologyGentamicinDiabetes mellitusMedicine
32Publications
12H-index
317Citations
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Publications 32
Newest
#2Slavimir VeljkovicH-Index: 12
Last. Ivan R. IlićH-Index: 7
view all 5 authors...
: Due to high relative blood flow the kidney is prone to drug-induced damage. Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced nephrotoxicity. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. Application of gentamicin is still related to serious side effects which are reported more often compared to other antibiotics. Because gentamicin is still heavily used and i...
14 CitationsSource
Salicylic acid is a phytochemical with beneficial effects on human well-being. Salicylic acid is a phenolic compound and is present in various plants where it has a vital role in protection against pathogenic agents. Natural sources include fruits, vegetables and spices. The most famous and defined effect of salicylic acid is prostaglandin synthesis inhibition. Salicylic acid has antiinflammatory effects through suppression of transcription of genes for cyclooxygenase. Most of the pharmacologica...
5 CitationsSource
#1Sonja Ilić (University of Niš)H-Index: 4
#2Nenad Stojiljković (University of Niš)H-Index: 11
Last. Gordana Stojanović (University of Niš)H-Index: 22
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The aim of this study was to investigate the possible effect of quercetin on cisplatin-induced nephrotoxicity in rats. Experiments were done on thirty-two Wistar rats divided into four groups of 8 animals each. The CIS group received a single dose of cisplatin (8 mg/kg) intraperitoneally, whereas the CISQ group received quercetin intraperitoneally at a dose of 50 mg/kg for 9 days and a single dose of cisplatin intraperitoneally (8 mg/kg) on the fifth day. Animals in the Q group received querceti...
6 Citations
#1Jasmina Djordjevic-Jocic (University of Niš)H-Index: 5
#2Rade Cukuranovic (University of Niš)H-Index: 13
Last. Vladisav Stefanovic (University of Niš)H-Index: 23
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The goal of this study was to examine, the relationship between chronic kidney disease (CKD) and glaucomatous optic disc neuropathy in a cohort of patients from the south-east Serbia and to determine whether limited screening for glaucoma in specific subgroups of patients with CKD is reasonable and justifiable. This cross-sectional study included 328 subjects with various stages of CKD. All patients had visited the Outpatient Department of the Nephrology Clinic, Clinical Center Nis, Serbia. All ...
2 CitationsSource
#1Pedja KovacevicH-Index: 3
#2Saša DragićH-Index: 2
Last. Tijana KovacevicH-Index: 3
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AbstractEnd-stage renal disease (ESRD) and its treatment modules affect almost all organs and organ systems including vascular endothelium. It is well known that disturbance of vasoactive substances (nitric oxide – NO and endothelin-1 – ET-1) production appears in these patients. There is a small number of studies which investigated serum levels of NO and ET-1 in ESRD patients treated with continuous ambulatory peritoneal dialysis (CAPD). Therefore our study aimed to measure serum levels of NO a...
3 CitationsSource
#1Pedja KovacevicH-Index: 3
#2Mirko StaneticH-Index: 2
Last. Meyer Fj (University Hospital Heidelberg)H-Index: 1
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Background and Aim. Several studies demonstrated a six-fold increase in plasma concentration of endothelin-1 (ET-1) in diaysis patients (hemodialysis and peritoneal dialysis) compared to healthy control subjects. However, the effects of ET-1 on respiratory function in these patients are less known. The aim of this study was to determine the potential differences in spirometric values in relation to ET-1 levels. Methods. The study included 28 patients (15 male, 13 female, mean age 55.9±16. 2 year...
4 CitationsSource
#1Pedja KovacevicH-Index: 3
#2Zvezdana RajkovacaH-Index: 4
Last. Slavimir VeljkovicH-Index: 12
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Complications of respiratory system in patients suffering from chronic renal failure who are treated with regular haemodialysis are well known. However, the effects of interdialytic weight gain on respiratory function in these patients are less known. Hence, this study was designed with the aim to determine the potential differences in spirometry related to the different interdialytic weight gain. The study included 32 patients, 16 males (50%) aged 51 (± 11), with ESRD who had been treated with ...
1 CitationsSource
#1Pavle J. Randjelović (University of Niš)H-Index: 12
#2Slavimir Veljkovic (University of Niš)H-Index: 12
Last. Ivan R. Ilić (University of Niš)H-Index: 7
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Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine ...
28 CitationsSource
Gentamicin (GM) is a widely used antibiotic against serious, life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of selenium (Se) in GM-induced nephrotoxicity in rats. Experiments were done on 32 adult Wistar rats divided into four groups of 8 animals each. The GM group received gentamicin (100 mg/kg), whereas the GM+Se group received the same dose of GM and selenium (1 mg/kg) by intrap...
23 CitationsSource
#1Nenad Stojiljković (University of Niš)H-Index: 11
#2Milan Stoiljkovic (University of Niš)H-Index: 8
Last. Dragan Mihailovic (University of Niš)H-Index: 41
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Since gentamicin-induced nephrotoxicity has very important clinical consequences, different potentially therapeutic approaches to prevent or attenuate it have been proposed. Accordingly, this study aimed at determining the possible protective effects of vitamin C against gentamicin-associated acute kidney injury. Experiments were done on 40 adult Wistar rats divided into four groups of 10 animals each. G-group received gentamicin (100 mg/kg) while GVC-group received the same dose of gentamicin a...
29 CitationsSource
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