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Ben Schoettker
German Cancer Research Center
199Publications
43H-index
18.5kCitations
Publications 199
Newest
#1Alexander TeumerH-Index: 70
#2Yong Li (University of Freiburg)H-Index: 26
Last.Anna Köttgen (Johns Hopkins University)H-Index: 52
view all 186 authors...
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an ind...
#1Xīn Gào (DKFZ: German Cancer Research Center)H-Index: 9
#2Yan Zhang (DKFZ: German Cancer Research Center)H-Index: 29
Last.Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
view all 7 authors...
Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data (2000–2016). Blood DNA methylation in promoter regions of 519 genes, known to be involved in pathways from oxidative stress (OS) to...
#1Xīn Gào (DKFZ: German Cancer Research Center)H-Index: 9
#2Bernd HolleczekH-Index: 33
Last.Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
view all 9 authors...
Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2′-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were ...
#1Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
#2Yang Xuan (DKFZ: German Cancer Research Center)H-Index: 2
Last.Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 5 authors...
OBJECTIVE Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results. RESEARCH DESIGN AND METHODS We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with typ...
#1Johanna Katharina Hohls (UHH: University of Hamburg)H-Index: 2
#2Hans-Helmut König (UHH: University of Hamburg)H-Index: 47
Last.Beate Wild (University Hospital Heidelberg)H-Index: 13
view all 11 authors...
#1Stephen KaptogeH-Index: 51
#2Lisa PennellsH-Index: 12
Last.Emanuele Di AngelantonioH-Index: 54
view all 101 authors...
Summary Background To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. Methods In this model revision initiative, we derived 10-year risk prediction models for fatal an...
#1Hannah Stocker (DKFZ: German Cancer Research Center)H-Index: 1
#2Andreas Nabers (RUB: Ruhr University Bochum)H-Index: 5
Last.Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 10 authors...
Abstract Introduction Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of Aβ misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods Within a community-based cohort, Aβ misfolding in plasma measured by immuno-infrared sensor and APOE genotype were determined at baseline in 770 participants followed over 14 years. Associations between Aβ misfolding, APOE4, and ...
#2Wolfgang HerzogH-Index: 35
Last.Beate WildH-Index: 17
view all 7 authors...
Abstract Background Anxiety in older age is common. In comparison with men, older women experience higher levels of anxiety and show different patterns of co-occurring mental disorders. The aim of this study is to investigate gender-specific biopsychosocial predictors associated with GAD (Generalized Anxiety Disorder) symptoms after a period of three years in the elderly population. Methods Data were derived from the third (2008—2010) and the fourth follow-up (2011— 2014) of the large population...
#2Degu AbateH-Index: 7
Last.Christopher MargonoH-Index: 162
view all 628 authors...
Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving ...
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