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Ben Schoettker
German Cancer Research Center
Cohort studyPopulationDiabetes mellitusMedicineCohort
199Publications
43H-index
18.5kCitations
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Publications 235
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#1Haixin Yu (DKFZ: German Cancer Research Center)H-Index: 1
#2Janhavi R. Raut (DKFZ: German Cancer Research Center)
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 6 authors...
Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional consideration of genetic risk scores (GRSs) and epigenetic risk scores defined by DNA methylation. We conducted a nested case-control study of 143 incident LC cases and 1460 LC-free controls within a prospective cohort of 9949 participants aged 50–75 years with 14-year follow-up. Lifetime smoking hi...
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#1Jiantao Ma (NIH: National Institutes of Health)H-Index: 12
#2Casey M. Rebholz (Johns Hopkins University)H-Index: 18
Last. Michael M. Mendelson (NIH: National Institutes of Health)H-Index: 14
view all 50 authors...
Background - DNA methylation patterns associated with habitual diet have not been well studied. Methods - Diet quality was characterized using a Mediterranean-style diet score (MDS) and the Alternative Healthy Eating Index score (AHEI). We conducted ethnicity-specific and trans-ethnic epigenome-wide association analyses for diet quality and leukocyte-derived DNA methylation at over 400,000 cytosine-guanine dinucleotides (CpGs) in five population-based cohorts including 6,662 European ancestry (E...
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#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 11
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 4
Last. Henrik Grönberg (KI: Karolinska Institutet)H-Index: 72
view all 57 authors...
We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated...
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#1Cristina TaddeiH-Index: 9
#2Bin ZhouH-Index: 17
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High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels...
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#1Li-Ju Chen (DKFZ: German Cancer Research Center)
#2Kira Trares (DKFZ: German Cancer Research Center)
Last. Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
view all 6 authors...
BACKGROUND Both polypharmacy and potentially inappropriate medication (PIM) intake are highly prevailing in older cancer patients. However, only studies on the association of polypharmacy and post-operative complications have been meta-analyzed previously. METHODS A systematic review and a meta-analysis of prospective/retrospective observational studies reporting associations of polypharmacy or PIM with at least 1 out of 5 pre-defined adverse health outcomes in a population of older cancer patie...
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#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 7
Last. Manjeet K. Bolla (University of Cambridge)H-Index: 30
view all 272 authors...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1–3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 ...
1 CitationsSource
#1Bernd Holleczek (DKFZ: German Cancer Research Center)H-Index: 33
#1B. Holleczek (DKFZ: German Cancer Research Center)H-Index: 14
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 3 authors...
: Helicobacter pylori (H. pylori) infection is considered as principal cause of gastric cancer. It is further associated with a reduced risk of esophageal adenocarcinomas. In a large prospective population-based cohort study including 9,949 subjects with average observation time of 13.8 years, we assessed the risk of invasive gastric and esophageal cancer according to H. pylori infection and presence of chronic atrophic gastritis (CAG). Incidence rates and hazard ratios (HR) derived by Cox propo...
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#1Hannah Stocker (DKFZ: German Cancer Research Center)H-Index: 1
#2Laura Perna (DKFZ: German Cancer Research Center)H-Index: 14
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 9 authors...
The strongest genetic risk factor for Alzheimer’s disease (AD) is the e4 allele of Apolipoprotein E (APOE) and recent genome-wide association meta-analyses have confirmed additional associated genetic loci with smaller effects. The aim of this study was to investigate the ability of an AD polygenic risk score (PRS) and APOE status to predict clinical diagnosis of AD, vascular (VD), mixed (MD), and all-cause dementia in a community-based cohort prospectively followed over 17 years and secondarily...
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#1Pooja Middha Kapoor (DKFZ: German Cancer Research Center)H-Index: 1
#2Nasim Mavaddat (University of Cambridge)H-Index: 14
Last. Qin Wang (University of Cambridge)H-Index: 37
view all 143 authors...
Combining polygenic risk score (PRS) with classical risk factors could improve accuracy of breast cancer prediction models. We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors in women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overal...
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