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Pascal Finetti
Aix-Marseille University
178Publications
42H-index
6,990Citations
Publications 178
Newest
#1Sylvain Garciaz (AMU: Aix-Marseille University)H-Index: 4
#2Lia N’guyen Dasi (AMU: Aix-Marseille University)
Last.Luc Camoin (AMU: Aix-Marseille University)H-Index: 27
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The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular, functional, and prognosis significance of this epigenetic alteration named H3K27me3 HIST1 in NPM1-mutated (NPM1mut) CN-AML. We found that three quarter of the NPM1mut CN-AML patients were H3K27me3 HIST1high. H3K...
#2Pascal Finetti (AMU: Aix-Marseille University)H-Index: 42
Last.François Bertucci (AMU: Aix-Marseille University)
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ABSTRACTAdrenocortical carcinomas (ACCs) are heterogeneous cancers associated with a very poor prognosis. The improvement of prognostic tools and systemic therapy are urgently needed. Targeting the...
#1Abir Arfaoui (AMU: Aix-Marseille University)H-Index: 1
#2Claire Rioualen (AMU: Aix-Marseille University)H-Index: 4
Last.Candi Léonard‐Stumpf (AMU: Aix-Marseille University)
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Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to improve cancer treatment. Here, we carried out a genome-wide RNA interference screen to identify genes that regulate breast CSCs-fate (bCSC). Using an interactome/regulome analysis, we integrated screen results in a functional mapping of the CSC-relate...
#2Pascal FinettiH-Index: 42
Last.François BertucciH-Index: 53
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Triple negative breast cancer (TNBC) represent 15% of breast cancers. Histoclinical features and marketed prognostic gene expression signatures (GES) failed to identify good- and poor-prognosis patients. Tyrosine kinases (TK) represent potential prognostic and/or therapeutic targets for TNBC. We sought to define a prognostic TK GES in a large series of TNBC. mRNA expression and histoclinical data of 6379 early BCs were collected from 16 datasets. We searched for a TK-based GES associated with di...
#1Yuchen Guo (University of Montpellier)
#2Monica Gabola (University of Montpellier)
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To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in the mucosa, and signs of inflammation as well as an increased proliferation of CEC associated with the appearance of low- and high-grade dysplasia. The main initial events triggering those alterations in cyclin A2 deficient CEC appear to be abnormal mitoses and DNA damage. Cyclin ...
#1François Bertucci (AMU: Aix-Marseille University)H-Index: 53
#2Pascal Finetti (AMU: Aix-Marseille University)H-Index: 42
Last.Daniel Birnbaum (AMU: Aix-Marseille University)H-Index: 15
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#1Marguerite TyranH-Index: 2
#2Nadine CarbucciaH-Index: 22
Last.A. TalletH-Index: 12
view all 14 authors...
Improving the systemic treatment of brain metastases (BM) in primary breast cancer (PBC) is impaired by the lack of genomic characterization of BM. To estimate the concordance of DNA copy-number-alterations (CNAs), mutations, and actionable genetic alterations (AGAs) between paired samples, we performed whole-genome array-comparative-genomic-hybridization, and targeted-next-generation-sequencing on 14 clinical PBC–BM pairs. We found more CNAs, more mutations, and higher tumor mutational burden, ...
#1Romain Lévêque (French Institute of Health and Medical Research)
#2Cyril Corbet (French Institute of Health and Medical Research)H-Index: 3
Last.Nicolas MagnéH-Index: 38
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Abstract ProNGF expression has been linked to several types of cancers including breast cancer, and we have previously shown that proNGF stimulates breast cancer invasion in an autocrine manner through membrane receptors sortilin and TrkA. However, little is known regarding TrkA-associated protein partners upon proNGF stimulation. By proteomic analysis and proximity ligation assays, we found that proNGF binding to sortilin induced sequential formation of the functional sortilin/TrkA/EphA2 comple...
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