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A. Sistiaga
University of the Basque Country
14Publications
6H-index
176Citations
Publications 15
Newest
#1Garazi Labayru (UPV/EHU: University of the Basque Country)
#2Jone Aliri (UPV/EHU: University of the Basque Country)H-Index: 6
Last.A. Sistiaga (UPV/EHU: University of the Basque Country)H-Index: 6
view all 5 authors...
Source
#1Garazi Labayru (ISCIII: Carlos III Health Institute)
#2Garazi Labayru (ISCIII: Carlos III Health Institute)
Last.A. Sistiaga (UPV/EHU: University of the Basque Country)H-Index: 6
view all 8 authors...
Abstract Background Myotonic Dystrophy type 1 (DM1) is a slowly progressive myopathy characterized by varying multisystemic involvement. Several cerebral features such as brain atrophy, ventricular enlargement, and white matter lesions (WMLs) have frequently been described. The aim of this study is to investigate the structural organization of the brain that defines the disease through multimodal imaging analysis, and to analyze the relation between structural cerebral changes and DM1 clinical a...
Source
#1Garazi Labayru (UPV/EHU: University of the Basque Country)
#2Irati Arenzana (University of Barcelona)
Last.A. Sistiaga (UPV/EHU: University of the Basque Country)H-Index: 6
view all 6 authors...
Aims The cognitive profile of Myotonic Dystrophy type 1 (DM1) has been described in recent decades. Moreover, DM1 patients show lowered social engagement and difficulties in social-cognitive functions. The aim of the present study is to explore whether social cognition impairment is present in DM1 taking into account the overall cognitive condition. Method 38 patients and a control group paired in age and gender participated in the study. All the participants had an IQ within the normal range. S...
Source
#1S. López AlavaH-Index: 1
#2Jone AliriH-Index: 6
Last.A. SistiagaH-Index: 6
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Introduccion. Ser mujer aumenta el riesgo de padecer esclerosis multiple, enfermedad sobre la que diversos factores biopsicosociales (estres psicologico, apoyo social percibido, bienestar psicologico, estrategias de afrontamiento) pueden tener un impacto clinico. Objetivo. Valorar como afecta el manejo del estres en la esclerosis multiple remitente recurrente y analizar las diferencias de sexo tanto en el manejo del estres como en el rendimiento cognitivo de los pacientes. Pacientes y metodos. S...
1 CitationsSource
#1A. SistiagaH-Index: 6
Last.J. Olascoaga UrtazaH-Index: 22
view all 8 authors...
Introduccion. El deterioro cognitivo y la presencia de sintomas depresivos, comunes en los pacientes con esclerosis multiple, inciden en la calidad de vida de los pacientes. Objetivo. Describir la calidad de vida, la afectacion cognitiva y los niveles de depresion, en relacion con otras variables clinicas, en los pacientes con esclerosis multiple de la provincia de Gipuzkoa. Pacientes y metodos. Se evaluo neuropsicologicamente a 114 pacientes. Se incluyeron el MSQoL-54 y el inventario de depresi...
2 CitationsSource
#1Fermin Moreno (ISCIII: Carlos III Health Institute)H-Index: 13
#2Roser Sala-Llonch (University of Barcelona)H-Index: 24
Last.Begoña Indakoetxea (ISCIII: Carlos III Health Institute)H-Index: 9
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Abstract Studies in asymptomatic granulin gene ( GRN ) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinical GRN mutation carriers and to study the relationship of CTh with cognitive performance in GRN mutation carriers. We calculated CTh maps in 13 asymptomatic carriers of t...
9 CitationsSource
#1Juan Manuel GórrizH-Index: 34
#2Elmar LangH-Index: 26
Last.A. ZeilerH-Index: 6
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9 CitationsSource
#1Alexandre SavioH-Index: 15
Last.Adolfo López de MunainH-Index: 33
view all 10 authors...
#1Alexandre Savio (Grupo México)H-Index: 15
#2Maite García-Sebastián (Grupo México)H-Index: 10
Last.Jorge VillanuaH-Index: 9
view all 8 authors...
Dementia is a growing concern due to the aging process of the western societies. Non-invasive detection is therefore a high priority research endeavor. In this paper we report results of classification systems applied to the feature vectors obtained by a feature extraction method computed on structural magnetic resonance imaging (sMRI) volumes for the detection of two neurological disorders with cognitive impairment: myotonic dystrophy of type 1 (MD1) and Alzheimer disease (AD). The feature extr...
36 CitationsSource
#1Claire-Marie Dhaenens (French Institute of Health and Medical Research)H-Index: 15
#2Helene Tran (French Institute of Health and Medical Research)H-Index: 9
Last.Nicolas Sergeant (French Institute of Health and Medical Research)H-Index: 45
view all 21 authors...
Abstract Tau is the proteinaceous component of intraneuronal aggregates common to neurodegenerative diseases called Tauopathies, including myotonic dystrophy type 1. In myotonic dystrophy type 1, the presence of microtubule-associated protein Tau aggregates is associated with a mis-splicing of Tau. A toxic gain-of-function at the ribonucleic acid level is a major etiological factor responsible for the mis-splicing of several transcripts in myotonic dystrophy type 1. These are probably the conseq...
35 CitationsSource
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