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Barbara Franke
Radboud University Nijmegen
PsychiatryPsychologyAttention deficit hyperactivity disorderGeneticsBiology
610Publications
76H-index
25.4kCitations
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Publications 620
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#1Paul M. Thompson (SC: University of Southern California)H-Index: 141
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Willem Bruin (UvA: University of Amsterdam)H-Index: 1
view all 170 authors...
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in ...
6 CitationsSource
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)
view all 362 authors...
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
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#1Christienne G. Damatac (Radboud University Nijmegen)H-Index: 3
#2Marcel P. Zwiers (Radboud University Nijmegen)H-Index: 38
Last. Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 13 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter microstructure, measured by diffusion-weighted imaging (DWI) and quantified by fractional anisotropy (FA). In the largest DWI analysis of ADHD to date, we systematically investigated if FA is associated with: current and lifetime diagnosis, categorical diagnosis and continuo...
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#1Lara M. Wierenga (LEI: Leiden University)H-Index: 4
#2Gaelle E. Doucet (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 17
Last. Ole A. Andreassen (University of Oslo)H-Index: 89
view all 160 authors...
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy indivi...
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#2Sarita DamH-Index: 1
Last. Alejandro Arias VasquezH-Index: 24
view all 10 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD = 42; Ncontrols = 50; NsubthreholdADH...
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#1Milou Straathof (UU: Utrecht University)H-Index: 2
#2Erwin L. A. Blezer (UU: Utrecht University)H-Index: 27
Last. Maarten Mennes (Radboud University Nijmegen)H-Index: 35
view all 65 authors...
Abstract Obsessive-compulsive disorder (OCD) is increasingly considered to be a neurodevelopmental disorder. However, despite insights in neural substrates of OCD in adults, less is known about mechanisms underlying compulsivity during brain development in children and adolescents. Therefore, we developed an adolescent rat model of compulsive checking behavior and investigated developmental changes in structural and functional measures in the frontostriatal circuitry. Five-weeks old Sprague Dawl...
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#1Ida E. Sønderby (Oslo University Hospital)H-Index: 8
#2Omar Gustafsson (deCODE genetics)H-Index: 21
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 89
view all 153 authors...
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we...
3 CitationsSource
#1Ida E. Sønderby (Oslo University Hospital)H-Index: 8
#2Omar Gustafsson (deCODE genetics)H-Index: 21
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 89
view all 153 authors...
Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in the original article has now been updated to include all authors, and Supplementary Table 1 has been removed. All other supplementary files have now been updated accordingly. Furthermore, in Table 1 of this Article, the replication cohort for the row Close relative in data set, n (%) was i...
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Objective:Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with intellectual disability, and shared overlapping genetics...
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#1Estela M. Bruxel (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 6
#2Carlos R Moreira-Maia (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
Last. Djenifer B. Kappel (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
view all 16 authors...
The gene encoding adhesion G protein-coupled receptor L3 (ADGRL3, also referred to as latrophilin 3 or LPHN3) has been associated with ADHD susceptibility in independent ADHD samples. We conducted a systematic review and a comprehensive meta-analysis to summarize the associations between the most studied ADGRL3 polymorphisms (rs6551665, rs1947274, rs1947275, and rs2345039) and both childhood and adulthood ADHD. Eight association studies (seven published and one unpublished) fulfilled criteria fo...
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