André Tchernof
Laval University
Publications 280
The complex relationship between metabolic disease risk and body fat distribution in humans involves cellular characteristics that are specific to body fat compartments. Here we show depot-specific differences in the stromal vascular fraction of visceral and subcutaneous adipose tissue by performing single-cell RNA sequencing of tissue specimens from obese individuals. We characterize multiple immune cells, endothelial cells, fibroblasts, adipose and haematopoietic stem cell progenitors. Subpopu...
There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little is known about the impact of obesity on epigenetic aging of metabolically active visceral adipose tissue (VAT). Herein, we aimed to test whether obesity accelerates VAT epigenetic aging in subjects with severe obesity. A significant and positive correlation between chronological age and epigenetic age, estimated with a reduced ver...
#1Laurent BierthoH-Index: 12
#2Simone LemieuxH-Index: 48
Last.Christopher RodrigueH-Index: 2
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Similarities have been observed between substance dependence and overconsumption of food, leading to the development of the food addiction (FA) concept. While psychological markers of FA have often been documented, data on physiological markers remains scarce. This study aimed to investigate HPA-axis functioning through cortisol awakening response (CAR) in relation to FA among bariatric candidates. We hypothesized that participants presenting high FA symptomatology would present a blunted CAR wh...
#1Patricia LemieuxH-Index: 1
#2S. John Weisnagel (Laval University)H-Index: 24
Last.Claudia Gagnon (Laval University)H-Index: 7
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2 CitationsSource
#1Ina Maltais-Payette (Laval University)H-Index: 2
#2Bénédicte Allam-Ndoul (Laval University)H-Index: 4
Last.André Tchernof (Laval University)H-Index: 49
view all 5 authors...
Abstract Background and Aim Circulating level of glutamate, a by-product of the catabolism of branched-chain amino acids, has been positively correlated with visceral adipose tissue accumulation and waist circumference (WC). The aim of the present study was to assess the potential of using glutamate level to identify individuals with abdominal obesity and a high cardiometabolic risk. Methods and results The study sample included 99 men and 99 women. Fasting serum glutamate was measured using the...
#1Andréanne Michaud (Laval University)H-Index: 10
#2Mahsa Dadar (Montreal Neurological Institute and Hospital)H-Index: 10
Last.Alain Dagher (Montreal Neurological Institute and Hospital)H-Index: 60
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Background: MRI studies show that obese adults have reduced grey (GM) and white matter (WM) tissue density as well as altered WM integrity. It remains to be examined if bariatric surgery induces structural brain changes. The aim of this study is to characterize GM and WM density changes in a longitudinal setting, comparing pre- and post-operation and to determine whether these changes are related to inflammation and cardiometabolic markers. Methods: 29 severely obese participants scheduled to un...
#1Fernando F. AnhêH-Index: 13
#2Kevin P. FoleyH-Index: 13
Last.Jonathan D. SchertzerH-Index: 38
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Bariatric surgery (BS) is the most efficacious treatment against severe obesity and T2D. Among bariatric procedures, biliopancreatic diversion with duodenal switch (BPD-DS) can produce superior metabolic benefits compared with other surgical options. The mechanisms by which BPD-DS improve metabolic health are not well-understood, but there is evidence implicating the gut microbiota (GM) as contributor to changes in adiposity and consequently blood glucose control. We aimed to determine how the G...
#1Camille DugasH-Index: 3
#2Mélissa BélangerH-Index: 1
Last.Julie RobitailleH-Index: 20
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Children born from mothers with gestational diabetes mellitus (GDM) are at high-risk of obesity and type 2 diabetes. To date, there is a lack of effective strategies to prevent these complications. The aim of this study was to evaluate the association between diet quality and anthropometric and glycemic profiles of children exposed (GDM+) and unexposed (GDM–) to GDM. A total of 104 GDM+ and 38 GDM– children were included. Two 24-h dietary recall questionnaires were used to assess dietary intakes...
3 CitationsSource