Match!
Anna Roujeinikova
Monash University
ChemistryHelicobacter pyloriBiochemistryCrystallographyBiology
101Publications
19H-index
1,894Citations
What is this?
Publications 101
Newest
#1Yihienew M. Bezabih (College of Health Sciences, Bahrain)H-Index: 1
Last. Woldesellassie M. Bezabhe (UTAS: University of Tasmania)H-Index: 5
view all 7 authors...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus that may be sensitive to heat. We assessed whether the spread of coronavirus disease 2019 (COVID-19) correlates with air temperature. We also studied whether additional climate, geographical, and population variables were correlated. The total number of confirmed COVID-19 cases and mortality rates reported in each country between 1st Jan and 31st Mar 2020 were compared with the country9s three-month average atmosp...
Source
Last. Anna RoujeinikovaH-Index: 19
view all 4 authors...
Source
#1Mohammad Firoz Khan (DI: Discovery Institute)H-Index: 6
#1Mohammad Firoz Khan (DI: Discovery Institute)H-Index: 4
Last. Anna RoujeinikovaH-Index: 19
view all 7 authors...
Chemotaxis is an important virulence factor of the foodborne pathogen Campylobacter jejuni. Inactivation of chemoreceptor Tlp3 reduces the ability of C. jejuni to invade human and chicken cells and to colonise the jejunal mucosa of mice. Knowledge of the structure of the ligand-binding domain (LBD) of Tlp3 in complex with its ligands is essential for a full understanding of the molecular recognition underpinning chemotaxis. To date, the only structure in complex with a signal molecule is Tlp3 LB...
Source
#1Mohammad M. Rahman (Monash University, Clayton campus)H-Index: 2
#2Alexandra Tikhomirova (Monash University, Clayton campus)H-Index: 1
Last. Anna Roujeinikova (Monash University, Clayton campus)H-Index: 19
view all 6 authors...
With the rise of bacterial resistance to conventional antibiotics, re-purposing of Food and Drug Administration (FDA) approved drugs currently used to treat non-bacteria related diseases as new leads for antibacterial drug discovery has become an attractive alternative. Ethoxzolamide (EZA), an FDA-approved diuretic acting as a human carbonic anhydrase inhibitor, is known to kill the gastric pathogenic bacterium Helicobacter pylori in vitro via an, as yet, unknown mechanism. To date, EZA activity...
1 CitationsSource
#1Abu Iftiaf Md Salah Ud-Din (Monash University, Clayton campus)H-Index: 5
#2Mohammad F. Khan (Monash University)
Last. Anna Roujeinikova (Monash University, Clayton campus)H-Index: 19
view all 3 authors...
Motile bacteria follow gradients of nutrients or other environmental cues. Many bacterial chemoreceptors that sense exogenous amino acids contain a double Cache (dCache; calcium channels and chemotaxis receptors) ligand-binding domain (LBD). A growing number of studies suggest that broad-specificity dCache-type receptors that sense more than one amino acid are common. Here, we present an investigation into the mechanism by which the dCache LBD of the chemoreceptor CtaA from a plant growth-promot...
2 CitationsSource
#1Mohammad M. Rahman (Monash University, Clayton campus)H-Index: 2
#2Mayra A. Machuca (Monash University, Clayton campus)H-Index: 5
Last. Anna Roujeinikova (Monash University, Clayton campus)H-Index: 19
view all 6 authors...
ABSTRACT The gastric pathogen Helicobacter pylori has limited ability to use carbohydrates as a carbon source, relying instead on exogenous amino acids and peptides. Uptake of certain peptides by H. pylori requires an ATP binding cassette (ABC) transporter annotated dipeptide permease (Dpp). The transporter specificity is determined by its cognate substrate-binding protein DppA, which captures ligands in the periplasm and delivers them to the permease. Here, we show that, unlike previously chara...
Source
#1Joyanta K. Modak (Monash University, Clayton campus)H-Index: 9
#1Joyanta K. Modak (Monash University, Clayton campus)H-Index: 3
Last. Anna Roujeinikova (Monash University, Clayton campus)H-Index: 19
view all 11 authors...
AbstractEthoxzolamide (EZA), acetazolamide, and methazolamide are clinically used sulphonamide drugs designed to treat non-bacteria-related illnesses (e.g. glaucoma), but they also show antimicrobi...
6 CitationsSource
#1Mohammad M. RahmanH-Index: 2
#2Mayra A. MachucaH-Index: 5
Last. Anna RoujeinikovaH-Index: 19
view all 6 authors...
Source
#1Mohammad M. RahmanH-Index: 2
#2Mayra A. MachucaH-Index: 5
Last. Anna RoujeinikovaH-Index: 19
view all 6 authors...
Source
#1Mohammad M. Rahman (DI: Discovery Institute)H-Index: 2
#2Mayra A. Machuca (DI: Discovery Institute)H-Index: 5
Last. Anna Roujeinikova (Monash University)H-Index: 19
view all 3 authors...
: Periplasmic binding proteins (PBPs) of Gram-negative bacteria sense essential nutrients and mediate their uptake by ATP-binding cassette (ABC) transporters. The gene for a PBP of H. pylori SS1, annotated as GlnH, is located within the glnPQH operon encoding an ABC importer system. In this study, GlnH has been expressed in E. coli and purified to > 98% homogeneity. The recombinant protein was folded according to the circular dichroism (CD) analysis and behaved as a monomer in solution. Crystals...
Source
12345678910