John F. Timms
University College London
Molecular biologyProteomicsBiochemistryBiomarker (medicine)Biology
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Publications 140
#1Kaloyan Takov (UCL: University College London)H-Index: 4
#2Zhenhe He (UCL: University College London)H-Index: 3
Last. Sean M. Davidson (UCL: University College London)H-Index: 48
view all 7 authors...
Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of impurities. Here, we studied the cardioprotective and proangiogenic activities of size-exclusion chromatography-purified sEVs secreted from human foetal amniotic fluid stem cells (S...
1 CitationsSource
#1Harry J. Whitwell (UCL: University College London)H-Index: 6
#2Jenny Worthington (UCL: University College London)H-Index: 4
Last. John F. Timms (UCL: University College London)H-Index: 30
view all 11 authors...
Ovarian cancer has a poor survival rate due to late diagnosis and improved methods are needed for its early detection. Our primary objective was to identify and incorporate additional biomarkers into longitudinal models to improve on the performance of CA125 as a first-line screening test for ovarian cancer. This case–control study nested within UKCTOCS used 490 serial serum samples from 49 women later diagnosed with ovarian cancer and 31 control women who were cancer-free. Proteomics-based biom...
#1Nuno R Nené (UCL: University College London)H-Index: 1
#2Daniel Reisel (UCL: University College London)H-Index: 7
Last. Martin Widschwendter (UCL: University College London)H-Index: 49
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Summary Background Various factors—including age, family history, inflammation, reproductive factors, and tubal ligation—modulate the risk of ovarian cancer. In this study, our aim was to establish whether women with, or at risk of developing, ovarian cancer have an imbalanced cervicovaginal microbiome. Methods We did a case-control study in two sets of women aged 18–87 years in the Czech Republic, Germany, Italy, Norway, and the UK. The ovarian cancer set comprised women with epithelial ovarian...
1 CitationsSource
#1Stella Irungu (UCL: University College London)
#2Dimitrios Mavrelos (UCLH: University College Hospital)H-Index: 18
Last. John F. Timms (UCL: University College London)H-Index: 30
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Background Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potentially serious complications, and is often delayed. Non-invasive biomarkers are urgently required to accelerate diagnosis and for triaging potential patients for surgery.
#1Darren S. Thomas (UCL: University College London)
#2Aleksandra Gentry-Maharaj (UCL: University College London)H-Index: 35
Last. Usha Menon (UCL: University College London)H-Index: 51
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Abstract Background Electronic health records are frequently used for cancer epidemiology. We report on their quality for ascertaining colorectal cancer (CRC) in UK women. Methods Population-based, retrospective cohort study nested within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Postmenopausal women aged 50–74 who were diagnosed with CRC during 2001–11 following randomisation to the UKCTOCS were identified and their diagnosis confirmed with their treating clinician. The ...
#1Oleg Blyuss (UCL: University College London)H-Index: 6
#2Matthew Burnell (UCL: University College London)H-Index: 21
Last. Usha Menon (UCL: University College London)H-Index: 51
view all 13 authors...
Purpose: In the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), women in the multimodal (MMS) arm had a serum CA125 test (first-line), with those at increased risk, having repeat CA125/ultrasound (second-line test). CA125 was interpreted using the “Risk of Ovarian Cancer Algorithm” (ROCA). We report on performance of other serial algorithms and a single CA125 threshold as a first-line screen in the UKCTOCS dataset. Experimental Design: 50,083 post-menopausal women who a...
5 CitationsSource
#1Inés P. Mariño (UCL: University College London)H-Index: 2
#2Oleg Blyuss (UCL: University College London)H-Index: 6
Last. Alexey Zaikin (UCL: University College London)H-Index: 24
view all 10 authors...
Abstract Ovarian cancer is the fifth most common cause of cancer-related deaths among women, with more than 150,000 deceases worldwide each year. One of the main problems of ovarian cancer is that, usually, is detected at later stages, for which the survival rates are relatively low. Thus, the development of new approaches for longitudinal multi-marker analysis that result in earlier detection may significantly impact on mortality. An issue of specific interest is to determine whether the baseli...
#1Harry J. WhitwellH-Index: 6
#2Oleg BlyussH-Index: 6
Last. Alexey ZaikinH-Index: 24
view all 5 authors...
// Harry J. Whitwell 1 , Oleg Blyuss 2 , Usha Menon 3 , John F. Timms 3 and Alexey Zaikin 3, 4 1 Chemical Engineering, Imperial College London, London, United Kingdom 2 Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom 3 Institute for Women’s Health, University College London, London, United Kingdom 4 Department of Mathematics, University College London, London, United Kingdom Correspondence to: Harry J. Whitwell, email: J...
2 CitationsSource
#1Joy CuencoH-Index: 2
#2Natascha WehnertH-Index: 1
Last. John F. TimmsH-Index: 30
view all 10 authors...
// Joy Cuenco 1 , Natascha Wehnert 2 , Oleg Blyuss 1 , Anna Kazarian 1 , Harry J. Whitwell 1 , Usha Menon 1 , Anne Dawnay 3 , Michael P. Manns 2 , Stephen P. Pereira 4 and John F. Timms 1 1 Institute for Women's Health, University College London, London, WC1E 6BT, UK 2 Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Carl-Neuberg-Strase 1, Hannover, 30625, Germany 3 Clinical Biochemistry, University College London Hospitals NHS Foundation Trust, London, W1T ...
3 CitationsSource
#1Kathryn Wolhuter (St Thomas' Hospital)H-Index: 3
#2Harry J. Whitwell (UCL: University College London)H-Index: 6
Last. Philip Eaton (St Thomas' Hospital)H-Index: 34
view all 6 authors...
Summary S-nitrosation, commonly referred to as S-nitrosylation, is widely regarded as a ubiquitous, stable post-translational modification that directly regulates many proteins. Such a widespread role would appear to be incompatible with the inherent lability of the S-nitroso bond, especially its propensity to rapidly react with thiols to generate disulfide bonds. As anticipated, we observed robust and widespread protein S-nitrosation after exposing cells to nitrosocysteine or lipopolysaccharide...
20 CitationsSource