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T Koekemoer
Nelson Mandela Metropolitan University
41Publications
8H-index
150Citations
Publications 41
Newest
#1Mutenta N. NyambeH-Index: 1
#2T KoekemoerH-Index: 8
Last.Denzil R. BeukesH-Index: 5
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Background: Comprised of Crohn’s disease and ulcerative colitis, inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the gastro-intestinal tract, which often results in severe damage to the intestinal mucosa. This study investigated metabolites from the South African endemic alga, Sargassum incisifolium, as potential treatments for IBD. Phytochemical evaluation of S. incisifolium yielded prenylated toluhydroquinones and toluquinones, from which semi-synthetic analogs w...
1 CitationsSource
#1Anna C. HattinghH-Index: 1
Last.T KoekemoerH-Index: 8
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Abstract Rooibos (Aspalathus linearis) is a South African fynbos plant, well-known for its strong anti-oxidant capacity and use in cosmetic products. The anti-ageing properties of fermented and green (unfermented) rooibos were investigated using a cell culture model designed to evaluate the involvement of mitochondrial dysfunction in the age-related decline in preadipocyte function. Mitochondrial dysfunction was induced through long-term exposure of 3T3-L1 preadipocytes to ethidium bromide (EtBr...
1 CitationsSource
#1Akinleye Akinrinde (University of Fort Hare)H-Index: 1
#2T Koekemoer (NMU: Nelson Mandela Metropolitan University)H-Index: 8
Last.Graeme Bradley (University of Fort Hare)H-Index: 17
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#1Nadine A. PringleH-Index: 1
Last.T KoekemoerH-Index: 8
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#1Akinleye Akinrinde (University of Fort Hare)H-Index: 1
#2Maryna van de Venter (NMU: Nelson Mandela Metropolitan University)H-Index: 13
Last.Graeme Bradley (University of Fort Hare)H-Index: 17
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Background: The roots of Dianthus thunbergii SS Hooper are used traditionally in South Africa for the treatment of diabetes, wounds, colic, chest complaints and cancer. This study was aimed at investigating the potential anti-proliferative activities of the D. thunbergii in mammalian cancer cell lines. Materials and Methods: Aqueous and ethanol extracts of D. thunbergii were tested in vitro on two cancer cell lines: human hepato-cellular carcinoma (HepG2) cells and murine insulinoma (INS-1) cell...
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#1Idowu Jonas Sagbo (University of Fort Hare)H-Index: 2
#2Maryna van de Venter (NMU: Nelson Mandela Metropolitan University)H-Index: 13
Last.Graeme Bradley (University of Fort Hare)H-Index: 17
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In South Africa, the number of people suffering from diabetes is believed to be rising steadily and the current antidiabetic therapies are frequently reported to have adverse side effects. Ethnomedicinal plant use has shown promise for the development of cheaper, cost-effective antidiabetic agents with fewer side effects. The aim of this study was to investigate the antidiabetic activity and mechanism of action of aqueous leaf extract prepared from Brachylaena elliptica. The potential of the ext...
2 CitationsSource
#1Nadine A. PringleH-Index: 1
#2T KoekemoerH-Index: 8
Last.Maryna van de VenterH-Index: 13
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The process of wound healing constitutes an ordered sequence of events that provides numerous opportunities for therapeutic intervention to improve wound repair. Rooibos, Aspalathus linearis , is a popular ingredient in skin care products, however, little scientific data exists exploring its therapeutic potential. In the present study, we evaluated the effects of fermented and aspalathin-enriched green rooibos in various in vitro models representative of dermal wound healing. Treatment of RAW 26...
1 CitationsSource
#1M.B. Ibrahim (University of Lagos)H-Index: 3
#2Abimbola Sowemimo (University of Lagos)H-Index: 8
Last.M. van de VenterH-Index: 15
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Abstract Phytochemicals are increasingly being used in cancer treatment due to affordability and potential anticancer effect with minimal adverse reactions compared to chemotherapy. Markhamia tomentosa is a medicinal plant used traditionally to treat cancer. In this study, the antiproliferative compounds from M. tomentosa were isolated using bioactivity-guided approach and characterized using various spectroscopic techniques. Through bioassay-guided fractionation of the crude ethanolic leaf extr...
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#1Gerhardt J. Boukes (NMU: Nelson Mandela Metropolitan University)H-Index: 6
#2T Koekemoer (NMU: Nelson Mandela Metropolitan University)H-Index: 8
Last.S. Govender (NMU: Nelson Mandela Metropolitan University)H-Index: 2
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Abstract Fungi are an important source of traditional medicine in Asian and Western countries. Globally, cancer is one of the leading causes of death with 22 million cases predicted by 2030. The cytotoxicity of 13 South African macrofungal species against HeLa, HT-29, MCF-7, MIA PaCa-2 and PC-3 cancer cell lines was measured using the 3-(4,5-dimethyl-2-thiazolul)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and the IC 50 values determined for the most cytotoxic macrofungal species. Fomitopsi...
1 CitationsSource
#1O. Eboji (University of Lagos)
#2Luanne Venables (NMU: Nelson Mandela Metropolitan University)H-Index: 4
Last.M. van de Venter (NMU: Nelson Mandela Metropolitan University)H-Index: 15
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Abstract Burkea africana Hook (Caesalpiniaceae) is a small to medium deciduous flat-topped tree up to 20 m tall that grows in Western and Southern Africa. Traditionally the bark decoction is used in treatment of fever, inflammation and cancer. Cytotoxic activity of the ethanolic extract was investigated using brine shrimp lethality assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using HeLa cells, cell cycle analysis, histone 3 phosphorylation, Caspase 3 and 8 acti...
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