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Valeria De Matteis
Istituto Italiano di Tecnologia
15Publications
6H-index
236Citations
Publications 15
Newest
Published on Mar 28, 2019in Nanoscale Research Letters
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 3 AuthorsRosaria Rinaldi
The nowadays growing use of nanoparticles (NPs) in commercial products does not match a comprehensive understanding of their potential harmfulness. More in vitro investigations are required to address how the physicochemical properties of NPs guide their engulfment within cells and their intracellular trafficking, fate, and toxicity. These nano-bio interactions have not been extensively addressed yet, especially from a mechanical viewpoint. Cell mechanic is a critical indicator of cell health be...
Published on Sep 21, 2019in International Journal of Molecular Sciences4.18
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 4 AuthorsR. Rinaldi29
Estimated H-index: 29
The widespread use of nanoparticles (NPs) in medical devices has opened a new scenario in the treatment and prevention of many diseases and infections owing to unique physico-chemical properties of NPs. In this way, silver nanoparticles (AgNPs) are known to have a strong antimicrobial activity, even at low concentrations, due to their ability to selectively destroy cellular membranes. In particular, in the field of dental medicine, the use of AgNPs in different kinds of dental prosthesis matrixe...
Published on Dec 31, 1969in Current Pharmaceutical Design2.41
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 1 AuthorsRosaria Rinaldi
Published on Jul 23, 2019in International Journal of Molecular Sciences4.18
Mariafrancesca Cascione7
Estimated H-index: 7
,
Valeria De Matteis6
Estimated H-index: 6
+ 2 AuthorsR. Rinaldi29
Estimated H-index: 29
The side effects induced by nanoparticle exposure at a cellular level are one of the priority research topics due to the steady increase in the use of nanoparticles (NPs). Recently, the focus on cellular morphology and mechanical behavior is gaining relevance in order to fully understand the cytotoxic mechanisms. In this regard, we have evaluated the morphomechanical alteration in human breast adenocarcinoma cell line (MCF-7) exposed to TiO2NPs at two different concentrations (25 and 50 µg/mL) a...
Published on May 28, 2019in Molecules3.06
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 2 AuthorsRosaria Rinaldi
Lauric acid is a green derivate that is abundant in some seeds such as coconut oil where it represents the most relevant fatty acid. Some studies have emphasized its anticancer effect due to apoptosis induction. In addition, the lauric acid is a Phase Change Material having a melting temperature of about 43.2 °C: this property makes it a powerful tool in cancer treatment by hyperthermal stress, generally induced at 43 °C. However, the direct use of lauric acid can have some controversial effects...
Published on Oct 1, 2018in Journal of Nanoparticle Research2.01
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 1 AuthorsStefano Leporatti25
Estimated H-index: 25
The unique physico-chemical properties of silver nanoparticles (AgNPs) make them a powerful tool in many fields, ranging from cosmetics, biomedicals, household products, and wound dressing. Several evidences suggest the strong toxicity of AgNPs both in vitro and in vivo, but few data are available to full understanding of their adverse effects on cellular components and cytoskeleton. In this work, we assessed the toxicity of citrate-capped AgNPs on cortical actin and organelles, namely mitochond...
Published on Jul 16, 2018in Cancers
Mariafrancesca Cascione7
Estimated H-index: 7
,
Valeria De Matteis6
Estimated H-index: 6
+ 1 AuthorsStefano Leporatti25
Estimated H-index: 25
The Epithelial to mesenchymal transition (EMT) is the process that drives epithelial tumor cells to acquire an invasive phenotype. The role of transforming growth factor-β1 (TGF-β1) in EMT is still debated. We used confocal laser scanning microscopy and scanning force spectroscopy to perform a morphomechanical analysis on epithelial breast cancer cells (MCF-7), comparing them before and after TGF-β1 exogenous stimulation (5 ng/mL for 48 h). After TGF-β1 treatment, loss of cell–cell adherence (ma...
Published on Jan 1, 2018
Valeria De Matteis6
Estimated H-index: 6
,
Rosaria Rinaldi12
Estimated H-index: 12
The wide use of engineered nanomaterials in many fields, ranging from biomedical, agriculture, environment, cosmetic, urged the scientific community to understand the processes behind their potential toxicity, in order to develop new strategies for human safety. As a matter of fact, there is a big discrepancy between the increased classes of nanoparticles and the consequent applications versus their toxicity assessment. Nanotoxicology is defined as the science that studies the effects of enginee...
Published on Nov 1, 2017in Experimental Cell Research3.33
Mariafrancesca Cascione7
Estimated H-index: 7
,
Valeria De Matteis6
Estimated H-index: 6
+ 3 AuthorsRosaria Rinaldi12
Estimated H-index: 12
Abstract The EMT phenomenon is based on tumour progression. The cells lose their physiologic phenotype and assumed a mesenchymal phenotype characterized by an increased migratory capacity, invasiveness and high resistance to apoptosis. In this process, RHO family regulates the activation or suppression of ROCK (Rho-associated coiled-coil containing protein kinase) which in turn regulates the cytoskeleton dynamics. However, while the biochemical mechanisms are widely investigated, a comprehensive...
Published on Jun 1, 2017in Journal of Nanoparticle Research2.01
Valeria De Matteis6
Estimated H-index: 6
,
Loris Rizzello14
Estimated H-index: 14
(UCL: University College London)
+ 1 AuthorsRosaria Rinaldi12
Estimated H-index: 12
The unique physicochemical properties of SiO2@Ag core/shell nanoparticles make them a promising tool in nanomedicine, where they are used as nanocarriers for several biomedical applications, including (but not restricted to) cancer treatment. However, a comprehensive estimation of their potential toxicity, as well as their degradation in the tumor microenvironment, has not been extensively addressed yet. We investigated in vitro the viability, the reactive oxygen species (ROS) production, the DN...
12