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Futwan Al-Mohanna
Alfaisal University
106Publications
27H-index
2,448Citations
Publications 106
Newest
#1Angela InglisH-Index: 9
#2Sherin ShibinH-Index: 1
Last.Kate S. CollisonH-Index: 17
view all 8 authors...
Abstract Introduction Small-animal models are the most widely used preclinical model for studying the etiology, pathology and treatment of diabetes, prediabetes and diabetic comorbidities. Diabetic patients are burdened with higher rates of depression, anxiety and cognitive decline due to inadequate control of blood glucose levels, vascular damage and aberrant CNS insulin signaling. The C57BL/6J model is amongst the most widely used mouse model due to its susceptibility to diet-induced obesity (...
#1Christopher W. Brey (Marywood University)H-Index: 2
#2Safoura Akbari-Alavijeh (RU: Rutgers University)H-Index: 1
Last.Sarwar Hashmi (RU: Rutgers University)H-Index: 11
view all 9 authors...
Summary Background Dietary salts sodium (Na+), potassium (K+), magnesium (Mg2+), and calcium (Ca2+) are important in metabolic diseases. Yet, we do not have sufficient understanding on the salts global molecular network in these diseases. In this systematic review we have pooled information to identify the general effect of salts on obesity, insulin resistance and hypertension. Aims To assess the roles of salts in metabolic disorders by focusing on their individual effect and the network effect ...
Background Pulmonary fibrosis is one of the leading indications for lung transplantation. The disease, which is of unknown aetiology, can be progressive, resulting in distortion of the extracellular matrix (ECM), inflammation, fibrosis and eventual death. Methods 13 patients born to consanguineous parents from two unrelated families presenting with interstitial lung disease were clinically investigated. Nine patients developed respiratory failure and subsequently died. Molecular genetic investig...
#1Ranad ShaheenH-Index: 27
#2Nan Jiang (UCSD: University of California, San Diego)
Last.Fowzan S. Alkuraya (Alfaisal University)H-Index: 50
view all 19 authors...
Ciliopathies are clinical disorders of the primary cilium with widely recognized phenotypic and genetic heterogeneity. In two Arab consanguineous families, we mapped a ciliopathy phenotype that most closely matches Joubert syndrome (hypotonia, developmental delay, typical facies, oculomotor apraxia, polydactyly, and subtle posterior fossa abnormalities) to a single locus in which a founder homozygous truncating variant in FAM149B1 was identified by exome sequencing. We subsequently identified a ...
#1Faisal A. Al-AllafH-Index: 13
#2Zainularifeen Abduljaleel (UQU: Umm al-Qura University)H-Index: 8
Last.Abdellatif Bouazzaoui (UQU: Umm al-Qura University)H-Index: 7
view all 16 authors...
Umm Al-Qura University and the King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia
#1Azizah A AlanaziH-Index: 2
#2Ranjit S. ParharH-Index: 25
Last.Futwan Al-Mohanna (Alfaisal University)H-Index: 27
view all 11 authors...
Abstract The data set presented here is associated with the article “Intracellular calcium and NF- k B regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes” (Al-Anazi et al., 2018). Data illustrate hypoxia-induced VEGF and leptin expression in human adipocytes treated with the calcium chelator BAPTA-AM (1 µM). It also shows NF-κB p65 induced expression by hypoxia. Preadipocytes were differentiated for 14 days and then subjected to 0.5–1.5% oxygen in the prese...
#1Azizah A AlanaziH-Index: 2
#2Ranjit S. ParharH-Index: 25
Last.Futwan Al-Mohanna (Alfaisal University)H-Index: 27
view all 11 authors...
Abstract Aims Hypoxia-induced adipokine release has been attributed mainly to HIF-1α. Here we investigate the role of intracellular calcium and NF-kB in the hypoxia-dependent release of leptin, VEGF, IL-6 and the hypoxia-induced inhibition of adiponectin release in human adipocytes. Main methods We used intracellular calcium imaging to compare calcium status in preadipocytes and in adipocytes. We subjected both cell types to hypoxic conditions and measured the release of adipokines induced by hy...
#1Kate S. CollisonH-Index: 17
#2Angela InglisH-Index: 9
Last.Futwan Al-MohannaH-Index: 27
view all 9 authors...
Rationale Aspartame (L-aspartyl phenylalanine methyl ester) is a non-nutritive sweetener (NNS) approved for use in more than 6000 dietary products and pharmaceuticals consumed by the general public including adults and children, pregnant and nursing mothers. However a recent prospective study reported a doubling of the risk of being overweight amongst 1-year old children whose mothers consumed NNS-sweetened beverages daily during pregnancy. We have previously shown that chronic aspartame (ASP) e...
Testing the equality of means of two normally distributed random variables when their variances are unequal is known in the statistical literature as the “Behrens-Fisher problem”. It is well-known that the posterior distributions of the parameters of interest are the primitive of Bayesian statistical inference. For routine implementation of statistical procedures based on posterior distributions, simple and efficient approaches are required. Since the computation of the exact posterior distribut...
#1Jun LingH-Index: 18
#2Christopher W. Brey (Marywood University)H-Index: 2
Last.Sarwar Hashmi (RU: Rutgers University)H-Index: 11
view all 14 authors...
Background Dietary salts are important factors in metabolic disorders. They are vital components of enzymes, vitamins, hormones, and signal transduction that act synergistically to regulate lipid metabolism. Our previous studies have identified that Kruppel-like factor −3 (KLF-3) is an essential regulator of lipid metabolism. However, it is not known if KLF-2 also regulates lipid metabolism and whether KLF-2 and −3 mediate the effects of dietary salts on lipid metabolism.
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