Futwan Al-Mohanna
Alfaisal University
EndocrinologyImmunologyDiabetes mellitusMedicineBiology
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Publications 110
#1Ayse Nurcan Cebeci (Istanbul Bilim University)H-Index: 1
#2Minjing ZouH-Index: 25
Last. Yufei ShiH-Index: 26
view all 10 authors...
CONTEXT: Hypophosphataemic rickets (HR) is a group of rare hereditary renal phosphate wasting disorders caused by mutations in the PHEX, FGF23, DMP1, ENPP1, CLCN5, SLC9A3R1, SLC34A1 or SLC34A3. OBJECTIVE: A large kindred with 5 HR patients were recruited with dominant inheritance. The study was undertaken to investigate underlying genetic defects in the HR patients. DESIGN: Patients and their family members were initially analyzed for PHEX and FGF23 mutations by PCR-sequencing and copy number an...
1 CitationsSource
#1Valarmathy Murugaiah (Brunel University London)H-Index: 4
#2Praveen M. Varghese (Brunel University London)
Last. Futwan Al-MohannaH-Index: 27
view all 11 authors...
The complement system is an ancient innate immune defence mechanism that can recognise molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface. Locally synthesised factor H at the site of infection/injury, including lungs, can act as a pattern recognition molecule without involving complement activation. Here, we report that factor H, a sialic acid binder, interacts with influenza A virus (I...
#1Faisal A. Al-Allaf (UQU: Umm al-Qura University)H-Index: 14
#2Zainularifeen Abduljaleel (UQU: Umm al-Qura University)H-Index: 8
Last. Abdellatif BouazzaouiH-Index: 7
view all 12 authors...
Familial hypercholesterolemia (FH) is an autosomal dominant disease most often caused by mutations in the low-density lipoprotein receptor (LDLR) gene, which consists of 18 exons spanning 45 kb and codes for a precursor protein of 860 amino acids. Mutations in the LDLR gene lead to a reduced hepatic clearance of LDL as well as a high risk of coronary artery disease (CAD) and sudden cardiac death (SCD). Recently, LDLR transgenes have generated interest as potential therapeutic agents. However, LD...
#1Angela InglisH-Index: 9
#2Sherin ShibinH-Index: 1
Last. Kate S. CollisonH-Index: 18
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Abstract Introduction Small-animal models are the most widely used preclinical model for studying the etiology, pathology and treatment of diabetes, prediabetes and diabetic comorbidities. Diabetic patients are burdened with higher rates of depression, anxiety and cognitive decline due to inadequate control of blood glucose levels, vascular damage and aberrant CNS insulin signaling. The C57BL/6J model is amongst the most widely used mouse model due to its susceptibility to diet-induced obesity (...
#1Christopher W. Brey (Marywood University)H-Index: 2
#2Safoura Akbari-Alavijeh (RU: Rutgers University)H-Index: 1
Last. Sarwar Hashmi (RU: Rutgers University)H-Index: 11
view all 9 authors...
Summary Background Dietary salts sodium (Na+), potassium (K+), magnesium (Mg2+), and calcium (Ca2+) are important in metabolic diseases. Yet, we do not have sufficient understanding on the salts global molecular network in these diseases. In this systematic review we have pooled information to identify the general effect of salts on obesity, insulin resistance and hypertension. Aims To assess the roles of salts in metabolic disorders by focusing on their individual effect and the network effect ...
1 CitationsSource
Background Pulmonary fibrosis is one of the leading indications for lung transplantation. The disease, which is of unknown aetiology, can be progressive, resulting in distortion of the extracellular matrix (ECM), inflammation, fibrosis and eventual death. Methods 13 patients born to consanguineous parents from two unrelated families presenting with interstitial lung disease were clinically investigated. Nine patients developed respiratory failure and subsequently died. Molecular genetic investig...
#1Ranad ShaheenH-Index: 31
#2Nan Jiang (UCSD: University of California, San Diego)H-Index: 1
Last. Fowzan S. Alkuraya (Alfaisal University)H-Index: 53
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Ciliopathies are clinical disorders of the primary cilium with widely recognized phenotypic and genetic heterogeneity. In two Arab consanguineous families, we mapped a ciliopathy phenotype that most closely matches Joubert syndrome (hypotonia, developmental delay, typical facies, oculomotor apraxia, polydactyly, and subtle posterior fossa abnormalities) to a single locus in which a founder homozygous truncating variant in FAM149B1 was identified by exome sequencing. We subsequently identified a ...
#1Faisal A. Al-AllafH-Index: 14
#2Zainularifeen Abduljaleel (UQU: Umm al-Qura University)H-Index: 8
Last. Abdellatif Bouazzaoui (UQU: Umm al-Qura University)H-Index: 7
view all 16 authors...
Umm Al-Qura University and the King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia
1 CitationsSource
#1Azizah A AlanaziH-Index: 2
#2Ranjit S. ParharH-Index: 26
Last. Futwan Al-Mohanna (Alfaisal University)H-Index: 27
view all 11 authors...
Abstract The data set presented here is associated with the article “Intracellular calcium and NF- k B regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes” (Al-Anazi et al., 2018). Data illustrate hypoxia-induced VEGF and leptin expression in human adipocytes treated with the calcium chelator BAPTA-AM (1 µM). It also shows NF-κB p65 induced expression by hypoxia. Preadipocytes were differentiated for 14 days and then subjected to 0.5–1.5% oxygen in the prese...
#1Azizah A AlanaziH-Index: 2
#2Ranjit S. ParharH-Index: 26
Last. Futwan Al-Mohanna (Alfaisal University)H-Index: 27
view all 11 authors...
Abstract Aims Hypoxia-induced adipokine release has been attributed mainly to HIF-1α. Here we investigate the role of intracellular calcium and NF-kB in the hypoxia-dependent release of leptin, VEGF, IL-6 and the hypoxia-induced inhibition of adiponectin release in human adipocytes. Main methods We used intracellular calcium imaging to compare calcium status in preadipocytes and in adipocytes. We subjected both cell types to hypoxic conditions and measured the release of adipokines induced by hy...
5 CitationsSource