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Eugene J. Barrett
University of Virginia
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
217Publications
55H-index
10.9kCitations
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Publications 210
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#2Linda A. JahnH-Index: 18
Last. Eugene J. BarrettH-Index: 55
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Introduction: Insulin exerts several opposing hemodynamic vascular actions, including stimulation of both nitric oxide-mediated vasodilation and endothelin-1-mediated vasoconstriction. Notably, hyperglycemia switches the vascular response to insulin from dilation to constriction in pre-clinical studies. To our knowledge, hyperglycemia’s effect on insulin’s action on vascular stiffness in humans is unknown. The American Heart Association recently recommended that vascular stiffness be determined ...
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#2Linda A. JahnH-Index: 18
Last. Zhenqi LiuH-Index: 36
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Insulin recruits muscle microvasculature to enhance insulin and nutrient delivery. Insulin resistance (IR) blunts this microvascular action. While metabolic and microvascular IR usually coexist, and phenotypic traits which foretell metabolic IR are well established, those which predict microvascular IR are unknown. To test whether metabolic IR and its associated traits predict microvascular IR, we performed euglycemic insulin clamps (1 mU/kg/min) in healthy lean (n= 57), healthy obese (n=15) and...
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#1Zhuo Fu (University of Virginia Health System)H-Index: 9
#2Liying Gong (CSU: Central South University)
Last. Zhenqi Liu (University of Virginia Health System)H-Index: 36
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Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are known to cross the blood brain barrier. To define the role of brain microvascular endothelial cells in GLP-1 entry into the brain, we infused labeled GLP-1 or exendin-4 into rats intra...
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#1Michelle A. Keske (UTAS: University of Tasmania)H-Index: 13
#2Eugene J. Barrett (UVA: University of Virginia)H-Index: 55
Last. Stephen M. Richards (UTAS: University of Tasmania)H-Index: 22
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1 CitationsSource
#1Nasui Wang (STU: Shantou University)H-Index: 2
#2Alvin W.K. Tan (University of Virginia Health System)H-Index: 2
Last. Zhenqi Liu (University of Virginia Health System)H-Index: 36
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OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either sal...
2 CitationsSource
#1Weidong ChaiH-Index: 15
#1Weidong Chai (UVA: University of Virginia)H-Index: 1
Last. Eugene J. Barrett (UVA: University of Virginia)H-Index: 55
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A high fat diet (HFD) can rapidly recruit neutrophils to insulin target tissues and within days induce microvascular insulin resistance (IR). Myeloperoxidase (MPO) is highly enriched in neutrophils...
1 CitationsSource
#1Eugene J. BarrettH-Index: 55
#2Weidong ChaiH-Index: 15
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HFD rapidly recruits neutrophils to insulin target tissues and induces microvascular IR. MPO is abundant in neutrophils, inhibits nitric oxide mediated vaso-relaxation, and associates with increased cardiovascular risk. AZD5904 (AstraZeneca) irreversibly inhibits MPO and is in clinical trials. MPO knockout, or chemical inhibition, improves glucose regulation in HFD-fed mice. Whether MPO affects muscle microvascular or metabolic IR in vivo is unknown. To test whether AZD5904 can prevent onset of ...
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#2Linda A. JahnH-Index: 18
Last. Eugene J. BarrettH-Index: 55
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Introduction: Chronic hyperglycemia injures both micro-and microvasculature. Conversely, insulin stimulates vascular nitric oxide production and acts as a vasodilator. Whether acute hyperglycemia (AH) inhibits insulin’s vasodilator action in healthy vasculature is unknown. Here we tested whether AH interfered with insulin’s action to recruit microvasculature, enhance endothelial function, or diminish vascular stiffness. Methods: Nine healthy, fasting subjects (ages 18-35 years; BMI 18-25 kg/m 2 ...
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#2Linda A. JahnH-Index: 18
Last. Eugene J. BarrettH-Index: 55
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Introduction: Over time, diabetes damages both the micro- and macrovasculature. Acutely, hyperglycemia causes oxidative stress and multiple biochemical abnormalities in endothelial cells. However, initial in vivo functional vascular responses to acute hyperglycemia (AH) are not well-characterized in humans or animals. Measurement of microvascular perfusion (MP) and endothelial function provides in vivo estimates of nutrient and hormone access to tissues and endothelial health, respectively. Meth...
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#1Joshua J. Neumiller (Washington State University Spokane)H-Index: 23
#2Rita R. Kalyani (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 28
Last. Eugene J. Barrett (UVA: University of Virginia)H-Index: 55
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2 CitationsSource
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