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Ken Sharpe
University of Melbourne
74Publications
26H-index
2,346Citations
Publications 74
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Purpose: To examine the effect of postexercise cold-water immersion (CWI) protocols, compared with control (CON), on the magnitude and time course of core temperature (Tc) responses. Methods: Pooled-data analyses were used to examine the Tc responses of 157 subjects from previous postexercise CWI trials in the authors’ laboratories. CWI protocols varied with different combinations of temperature, duration, immersion depth, and mode (continuous vs intermittent). Tc was examined as a double differ...
#1Brad Clark (UC: University of Canberra)H-Index: 1
#2Sarah M. Woolford (South Australian Sports Institute)H-Index: 10
Last.Christopher J. Gore (AIS: Australian Institute of Sport)H-Index: 46
view all 6 authors...
There is evidence to suggest athletes have adopted recombinant human erythropoietin (rHuEPO) dosing regimens that diminish the likelihood of being caught by direct detection techniques. However, the temporal response in physiology, performance, and Athlete Biological Passport (ABP) parameters to such regimens is not clearly understood. Participants were assigned to a high-dose only group (HIGH, n = 8, six rHuEPO doses of 250 IU/kg over two weeks), a combined high micro-dose group (COMB, n = 8, h...
#1Laurent Martin (Agence Française de Lutte contre le Dopage)H-Index: 11
#2Michael J. AshendenH-Index: 23
Last.Alexandre Marchand (Agence Française de Lutte contre le Dopage)H-Index: 3
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To minimize the chances of being caught after doping with recombinant human erythropoietins (rhEPO), athletes have turned to new practices using micro-doses and excess fluid ingestion to accelerate elimination and decrease the probability of detection. Our objective was to test the sensitivity of detection by validated methods (IEF: isoelectric focusing; SDS-PAGE: sodium dodecyl sulfate polyacrylamide gel electrophoresis) when such practices are used. First, after a three-week rhEPO boost period...
#1Laura A. Garvican-Lewis (AIS: Australian Institute of Sport)H-Index: 13
#2Ken Sharpe (University of Melbourne)H-Index: 26
Last.Christopher J. Gore (AIS: Australian Institute of Sport)H-Index: 6
view all 3 authors...
The overall "hypoxic dose" associated with altitude training for athletes is typically reported in the literature as hours of exposure. Current recommendations for altitude training are based around the need to acquire a given number of hours within a specific altitude range (typically 1800-3000 m); with the expected erythropoietic change proportional to the hours accumulated. We propose that elevation should also be incorporated when calculating the total dose of altitude exposure and introduce...
#1Laura A. Garvican-Lewis (AIS: Australian Institute of Sport)H-Index: 13
#2Ken Sharpe (University of Melbourne)H-Index: 26
Last.Christopher J. Gore (AIS: Australian Institute of Sport)H-Index: 46
view all 3 authors...
to the editor: The commentaries (see Ref. [3][1]) provided on our Viewpoint ([2][2]) is valuable and insightful. Our model is not without its limitations, as many have highlighted, particularly because we were unable to account for substantial variation in the response of hemoglobin mass (Hbmass) to
The reliability and accuracy of five portable blood lactate (BLa) analysers (Lactate Pro, Lactate Pro2, Lactate Scout+, Xpress™, and Edge) and one handheld point-of-care analyser (i-STAT) were compared to a criterion (Radiometer ABL90). Two devices of each brand of analyser were assessed using 22 x 6 mL blood samples taken from five subjects at rest and during exercise who generated lactate ranging ~1-23 mM. Each sample was measured simultaneously ~6 times on each device. Reliability was assesse...
#1Michael J. AshendenH-Index: 23
#2Ken Sharpe (University of Melbourne)H-Index: 26
Last.Christopher J. Gore (AIS: Australian Institute of Sport)H-Index: 46
view all 7 authors...
Summary Introduction Fluctuations in ambient temperature and pressure, as well as physical jostling, may affect the stability of whole blood samples transported by air freight. The aim of this study was to characterize the stability of key blood variables during air freight and to investigate whether vibration or reduced pressure alone affected results. Methods Over a 72-h interval, we evaluated the stability of full blood count indices (plus reticulocytes) in tubes that were air-freighted a tot...
#1J. MørkebergH-Index: 7
#2Ken Sharpe (University of Melbourne)H-Index: 26
Last.Michael J. AshendenH-Index: 23
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The detection of recombinant human erythropoietin (rhEPO) is difficult and becomes more challenging when only microdoses are administered intravenously. Twenty-three subjects were divided into two groups: EPO group (n = 7) and CONTROL group (n = 16). Seven urine and blood samples per subject were collected at least 5 days apart to determine within- and between-subject standard deviations in the percentage of migrating isoforms by the MAIIA test. Six injections of 50 IU/kg bw (boosting dosage) of...
#1Maneesha Bhullar (Royal Melbourne Hospital)H-Index: 1
#2Finlay Macrae (Royal Melbourne Hospital)H-Index: 48
Last.Ken Sharpe (University of Melbourne)H-Index: 26
view all 5 authors...
AIM: To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) and the natural history of Crohn’s disease (CD) to identify patients who would benefit from early aggressive medical intervention. METHODS: We recruited thirty consecutive unrelated CD patients with a history of ileo-caecal or small bowel resection during the period 1980-2000; Fifteen patients of these had post-operative relapse that required further surgery and fifteen ...
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