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Mary A. Schuler
University of Illinois at Urbana–Champaign
GeneMolecular biologyGeneticsBiochemistryBiology
173Publications
55H-index
12.4kCitations
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Publications 171
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#1Bernarda Calla (UIUC: University of Illinois at Urbana–Champaign)H-Index: 11
#2W.‐Y. Wu (UIUC: University of Illinois at Urbana–Champaign)
Last. May R. Berenbaum (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 5 authors...
: The parsnip webworm, Depressaria pastinacella, is restricted to two hostplant genera containing six structurally diverse furanocoumarins. Of these, imperatorin is detoxified by a specialized cytochrome P450, CYP6AB3. A previous whole-larva transcriptome analysis confirmed the presence of nine transcripts that belong to the CYP6AE subfamily. Here, by examining midgut-specific gene expression patterns we determined that CYP6AE89 transcripts were highly expressed and furanocoumarin-inducible. Com...
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#1Jisen Zhang (Fujian Agriculture and Forestry University)H-Index: 18
#2Xingtan Zhang (Fujian Agriculture and Forestry University)H-Index: 9
Last. Ray Ming (UIUC: University of Illinois at Urbana–Champaign)H-Index: 51
view all 108 authors...
In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should have read “The genome assembly and gene annotation have been deposited in the NCBI database under accession number QVOL00000000, BioProject number PRJNA483885 and BioSample number SAMN09753102. The data can also be downloaded from the following link: http://www.life.illinois.edu/ming/downloads/Spontaneum_g...
3 CitationsSource
#1Jisen Zhang (Fujian Agriculture and Forestry University)H-Index: 18
#2Xingtan Zhang (Fujian Agriculture and Forestry University)H-Index: 9
Last. Ray Ming (UIUC: University of Illinois at Urbana–Champaign)H-Index: 51
view all 108 authors...
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated the assembly of 32 pseudo-chromosomes comprising 8 homologous groups of 4 members each, bearing 35,525 genes with alleles defined. The reduction of basic chromosome number from 10 to 8 in S. spontaneum was caused by fissions of 2 ancestral chromosomes fo...
33 CitationsSource
#1Nektaria Petronikolou (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
#2Allison J. Hollatz (UIUC: University of Illinois at Urbana–Champaign)
Last. Satish K. Nair (UIUC: University of Illinois at Urbana–Champaign)H-Index: 37
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: Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. Loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin and demonstrates stereospecificity for the (6S,7R) substrate. We have biochemically characterized this biocatalyst and elucidated the basis for its strict substrate specificity. These studies could help facilitate the design of n...
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#2Bernarda CallaH-Index: 11
Last. Mary A. SchulerH-Index: 55
view all 4 authors...
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#1Bernarda Calla (UIUC: University of Illinois at Urbana–Champaign)H-Index: 11
#2Katherine Noble (UofU: University of Utah)H-Index: 2
Last. May R. Berenbaum (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 7 authors...
: Across insect genomes, the size of the cytochrome P450 monooxygenase (CYP) gene superfamily varies widely. CYPome size variation has been attributed to reciprocal adaptive radiations in insect detoxification genes in response to plant biosynthetic gene radiations driven by co-evolution between herbivores and their chemically defended hostplants. Alternatively, variation in CYPome size may be due to random "birth-and-death" processes, whereby exponential increase via gene duplications is limite...
16 CitationsSource
#1Wenfu Mao (UIUC: University of Illinois at Urbana–Champaign)H-Index: 13
#2Mary A. Schuler (UIUC: University of Illinois at Urbana–Champaign)H-Index: 55
Last. May R. Berenbaum (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 3 authors...
Cytochrome P450 monooxygenases (P450) in the honey bee, Apis mellifera , detoxify phytochemicals in honey and pollen. The flavonol quercetin is found ubiquitously and abundantly in pollen and frequently at lower concentrations in honey. Worker jelly consumed during the first 3 d of larval development typically contains flavonols at very low levels, however. RNA-Seq analysis of gene expression in neonates reared for three days on diets with and without quercetin revealed that, in addition to up-r...
29 CitationsSource
#1Wenfu Mao (UIUC: University of Illinois at Urbana–Champaign)H-Index: 13
#2Mary A. Schuler (UIUC: University of Illinois at Urbana–Champaign)H-Index: 55
Last. May R. Berenbaum (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 3 authors...
In insects, cytochrome P450 monooxygenases (P450s) contribute to phytochemical and pheromone clearance in chemoreception and xenobiotic detoxification in food processing. In eusocial species, P450 expression varies with anatomy and age-related behaviour. Adult honeybees (Apis mellifera) possess appendages differentially equipped for chemoreception; antennae and prothoracic and mesothoracic legs assess food and pheromone signals whereas metathoracic legs transport pollen over long distances. Newl...
16 CitationsSource
#1Wenfu Mao (UIUC: University of Illinois at Urbana–Champaign)H-Index: 13
#2Mary A. Schuler (UIUC: University of Illinois at Urbana–Champaign)H-Index: 55
Last. May R. Berenbaum (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 3 authors...
In the eusocial honey bee Apis mellifera, with reproductive queens and sterile workers, a female larva’s developmental fate depends on its diet; nurse bees feed queen-destined larvae exclusively royal jelly, a glandular secretion, but worker-destined larvae receive royal jelly for 3 days and subsequently jelly to which honey and beebread are added. RNA-Seq analysis demonstrated that p-coumaric acid, which is ubiquitous in honey and beebread, differentially regulates genes involved in caste deter...
35 CitationsSource
#1Stephanie A. Flowers (UTHSC: University of Tennessee Health Science Center)H-Index: 2
#2Brendan Colón (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
Last. P. David Rogers (UTHSC: University of Tennessee Health Science Center)H-Index: 31
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In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed in clinical isolates, the specific contributions of individual ERG11 mutations to azole resistance in C. albicans have not been widely explored. We sequenced ERG11 in 63 fluconazole (FLC)-resistant cli...
61 CitationsSource
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