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Wendy S. McDonough
Translational Genomics Research Institute
29Publications
19H-index
1,923Citations
Publications 29
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Review on SLC9A3R1 (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1), with data on DNA, on the protein encoded, and where the gene is implicated.
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#1Harshil Dhruv (TGen: Translational Genomics Research Institute)H-Index: 13
#2Wendy S. McDonough (TGen: Translational Genomics Research Institute)H-Index: 19
Last.Michael E. Berens (TGen: Translational Genomics Research Institute)H-Index: 53
view all 8 authors...
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Classic histological features of glioblastoma include dense proliferative areas rich in angiogenesis as well as centripetal dissemination of neoplastic cells into adjacent brain tissue (most frequently white matter). The infiltrative dispersion patterns of malignant glioma preclude complete tumor resection; growth of satellite lesions causes significant neurological morbidity and mortality, and accounts for much of the post...
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#1Matthew J. Ennis (TGen: Translational Genomics Research Institute)H-Index: 4
#2Wendy S. McDonough (TGen: Translational Genomics Research Institute)H-Index: 19
Last.Nhan L. Tran (TGen: Translational Genomics Research Institute)H-Index: 34
view all 8 authors...
Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. Despite efforts at surgical resection of the glioma mass, invasive cells are always left behind and the tumor will inevitably recur and kill the patient. As such, novel therapeutics targeting pro-invasive factors could improve neurological outcomes and survival for these patients. This requires a detailed understanding of the mechanisms driving glioma migration and invasion. We have been investigating whether the mult...
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#1Shannon P. Fortin (TGen: Translational Genomics Research Institute)H-Index: 3
#2Matthew J. Ennis (TGen: Translational Genomics Research Institute)H-Index: 4
Last.Nhan L. Tran (TGen: Translational Genomics Research Institute)H-Index: 34
view all 10 authors...
Malignant gliomas are the most common primary brain tumors.Despite intensive clinical investigation and significant technical advances in surgical and radiation treatment, the impact on clinical outcome for patients with malignant gliomas is disappointing.We have previously shown that tumor necrosis factor–like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell survival via binding to the Fn14 receptor, activation of the NF-κB pathway,...
43 CitationsSource
#1Kerri Kislin (TGen: Translational Genomics Research Institute)H-Index: 2
#2Wendy S. McDonough (TGen: Translational Genomics Research Institute)H-Index: 19
Last.Michael E. Berens (TGen: Translational Genomics Research Institute)H-Index: 53
view all 5 authors...
The invasive nature of malignant gliomas is a clinical problem rendering tumors incurable by conventional treatment modalities such as surgery, ionizing radiation, and temozolomide. Na + /H + exchanger regulatory factor 1 (NHERF-1) is a multifunctional adaptor protein, recruiting cytoplasmic signaling proteins and membrane receptors/transporters into functional complexes. This study revealed that NHERF-1 expression is increased in highly invasive cells that reside in the rim of glioblastoma mult...
57 CitationsSource
#1Bodour Salhia (U of T: University of Toronto)H-Index: 20
#2Nhan L. Tran (TGen: Translational Genomics Research Institute)H-Index: 34
Last.James T. Rutka (U of T: University of Toronto)H-Index: 70
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Malignant gliomas are characterized by their ability to invade normal brain tissue. We have previously shown that the small GTPase Rac1 plays a role in both migration and invasion in gliomas. Here, we aim to identify Rac-activating guanine nucleotide exchange factors (GEFs) that mediate glioblastoma invasiveness. Using a brain tumor expression database, we identified three GEFs, Trio, Ect2, and Vav3, that are expressed at higher levels in glioblastoma versus low-grade glioma. The expression of t...
125 CitationsSource
#1Amanda L. Willis (TGen: Translational Genomics Research Institute)H-Index: 10
#2Nhan L. Tran (TGen: Translational Genomics Research Institute)H-Index: 34
Last.Heather E. Cunliffe (TGen: Translational Genomics Research Institute)H-Index: 25
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Genomic characterization is beginning to define a molecular taxonomy for breast cancer; however, the molecular basis of invasion and metastasis remains poorly understood. We report a pivotal role for the fibroblast growth factor–inducible 14 (Fn14) receptor in this process. We examined whether Fn14 and its ligand tumor necrosis factor–like weak inducer of apoptosis (TWEAK) were expressed in breast tumors and whether deregulation of Fn14 levels affected malignant behavior of breast cancer cell li...
63 CitationsSource
#1Graciela GonzalezH-Index: 22
#2Juan C. UribeH-Index: 2
Last.Michael E. BerensH-Index: 53
view all 5 authors...
With the overwhelming volume of genomic and molecular information available on many databases nowadays, researchers need from bioinformaticians more than encouragement to refine their searches. We present here GeneRanker, an online system that allows researchers to obtain a ranked list of genes potentially related to a specific disease or biological process by combining gene-disease (or genebiological process) associations with protein-protein interactions extracted from the literature, using co...
8 Citations
#1Tim Demuth (TGen: Translational Genomics Research Institute)H-Index: 23
#2Jessica L. Rennert (TGen: Translational Genomics Research Institute)H-Index: 4
Last.Michael E. Berens (TGen: Translational Genomics Research Institute)H-Index: 53
view all 17 authors...
Background Glioblastoma multiforme (GBM) is the most common primary intracranial tumor and despite recent advances in treatment regimens, prognosis for affected patients remains poor. Active cell migration and invasion of GBM cells ultimately lead to ubiquitous tumor recurrence and patient death. To further understand the genetic mechanisms underlying the ability of glioma cells to migrate, we compared the matched transcriptional profiles of migratory and stationary populations of human glioma c...
57 CitationsSource
#1Tim Demuth (TGen: Translational Genomics Research Institute)H-Index: 23
#2Linsey B. Reavie (TGen: Translational Genomics Research Institute)H-Index: 4
Last.Michael E. Berens (TGen: Translational Genomics Research Institute)H-Index: 53
view all 11 authors...
2147 The early and pervasive tendency of cancer cells to invade into peritumoral normal tissue and to metastasize underlies the patient’s poor prognosis. This malignant spread of tumor cells prevents complete surgical resection and sequesters tumor cells outside the fields of focal radiation; each of these leads to heightened tumor recurrence. A three dimensional spheroid invasion assay was employed to model the invasive behavior of human glioma cells in vitro. Laser capture microdissection in c...
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