Alyn H. Morice
Hull York Medical School
Physical therapyChronic coughAnesthesiaDiabetes mellitusMedicine
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Publications 309
#1Jaclyn Smith (University of Manchester)H-Index: 1
#1Jaclyn A. Smith (University of Manchester)H-Index: 34
Last. David Muccino (MSD: Merck & Co.)H-Index: 1
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Summary Background Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate the efficacy of gefapixant compared with placebo after 12 weeks of treatment for refractory chronic cough or unexplained chronic cough. Methods We did a 12-week, phase 2b, randomised, double-blind, placebo-controlled study in patients with refractory chronic cough or unexplained chronic cough aged 18–80 years who w...
#1Alyn H. Morice (Hull York Medical School)H-Index: 30
#2Michael Kitt (MSD: Merck & Co.)H-Index: 4
Last. Caroline Wright (Hull York Medical School)H-Index: 7
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#1Sarah E. Holden (Cardiff University)H-Index: 11
#2Alyn H. Morice (Hull York Medical School)H-Index: 30
Last. Craig John Currie (Cardiff University)H-Index: 41
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AbstractObjective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC).Methods: This retrospective observa...
#1Ghassan Hamad (Hull York Medical School)
#2Alan S. Rigby (Hull York Medical School)H-Index: 42
Last. Alyn H. Morice (Hull York Medical School)H-Index: 30
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In the presence of normal CXR and examination perhaps FEV1 is a better diagnostic marker of COPD in primary care
#1Alyn H. Morice (Hull York Medical School)H-Index: 30
#2Eva Millqvist (Sahlgrenska University Hospital)H-Index: 28
Last. Angela Zacharasiewicz (University of Vienna)H-Index: 9
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These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist with cough variant asthma/eosinophilic bronchi...
10 CitationsSource
#1Jaclyn A. SmithH-Index: 34
#2Michael M. KittH-Index: 26
Last. David MuccinoH-Index: 1
view all 11 authors...
#1Surinder S. Birring (University of Cambridge)H-Index: 39
#2Lorcan McGarvey ('QUB': Queen's University Belfast)H-Index: 38
Last. Muccino (MSD: Merck & Co.)
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Background The negative impact of chronic cough on patients’ daily lives is multi-faceted; therefore, the evaluation of chronic cough treatment requires an approach including both objective and subjective measures. We assessed patient-reported outcomes (PROs) in a phase 2b clinical trial of gefapixant in patients with refractory or unexplained chronic cough (RCC or UCC). Methods This Phase 2b, 12-week, randomized controlled trial included subjects with severe RCC or UCC (duration >1 year; baseli...
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 11
#2Yvette Hayman (Hull York Medical School)H-Index: 2
Last. Alyn H. Morice (Hull York Medical School)H-Index: 30
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Purpose There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In this study, we characterise a human macrophage cell line, derived from THP-1 cells, and compare its phenotype to the THP-1 cells.
#1VJ Ludbrook (GSK: GlaxoSmithKline)H-Index: 1
#2KE Hanrott (GSK: GlaxoSmithKline)H-Index: 1
Last. Jaclyn A. Smith (University of Manchester)H-Index: 34
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Introduction and objectives Airway sensory nerves involved in the cough reflex may be mediated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) activation causes ATP release from airway macrophages and epithelial cells and it is hypothesised that a TRPV4-ATP-P2X3 axis contributes to chronic cough. The aim of this study was to evaluate, using an adaptive design, whether blockade of TRPV4 channels, using the selective ...
1 CitationsSource