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Nancie J. MacIver
Duke University
EndocrinologyImmunologyT cellBiologyImmune system
29Publications
13H-index
2,637Citations
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Publications 33
Newest
#1Kaitlin Kiernan (Duke University)H-Index: 1
#2Nancie J. MacIver (Duke University)H-Index: 13
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#1William D Green (UNC: University of North Carolina at Chapel Hill)H-Index: 4
#2Abrar E. Al-Shaer (UNC: University of North Carolina at Chapel Hill)H-Index: 1
Last. Saame Raza Shaikh (UNC: University of North Carolina at Chapel Hill)H-Index: 31
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Background: Obesity increases influenza disease risk in millions of adults worldwide. In this study, we investigated the effect of diet-induced obesity on pulmonary CD8+ T cell metabolism and function as a mechanism of impairment. Methods: Male C57BL/6J mice were fed either control (10% kcal/g) or high-fat (60% kcal/g) diet. Sub-lethal A/PR/8/34 influenza virus infection generated a robust pulmonary immune response. T cell metabolism and function were assessed at day 10 and day 24 post infection...
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#1Shengjun Fan (Duke University)H-Index: 1
#2Trevor T. Price (Duke University)H-Index: 3
Last. Nelson J. Chao (Duke University)H-Index: 61
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The roles of mitochondrial dysfunction in carcinogenesis remain largely unknown. The effects of PTEN-induced putative kinase 1 (PINK1)-dependent mitophagy on the pathogenesis of multiple myeloma (MM) are determined. The levels of the PINK1-dependent mitophagy markers PINK1 and parkin RBR E3 ubiquitin protein ligase (PARK2) in CD138(+) plasma cells are reduced in patients with MM and correlate with clinical outcomes in myeloma patients. Moreover, the induction of PINK1-dependent mitophagy with ca...
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#1Kaitlin Kiernan (Duke University)H-Index: 1
#2Nancie J. MacIver (Duke University)H-Index: 13
In their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of increased environmental long-chain fatty acid metabolites coupled with decreased fatty acid oxidation.
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It is now well established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partially controlled via epigenetic regulation. Epigenetic mechanisms, such as changes in DNA methylation or histone acetylation, have been found to alter immune function and play a role in numerous chronic d...
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#1Kevin H. Lin (Duke University)H-Index: 6
#2Abigail Xie (Duke University)H-Index: 2
Last. Kris C. Wood (Duke University)H-Index: 16
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Summary Crosstalk between metabolic and survival pathways is critical for cellular homeostasis, but the connectivity between these processes remains poorly defined. We used loss-of-function CRISPR/Cas9 knockout screening to identify metabolic genes capable of influencing cellular commitment to apoptosis, using sensitization to the BCL-2 inhibitor ABT-199 in BCL-2-dependent acute myeloid leukemia (AML) cell lines as a proxy for apoptotic disposition. This analysis revealed metabolic pathways that...
7 CitationsSource
#1Jennifer Rebeles (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#2William D Green (UNC: University of North Carolina at Chapel Hill)H-Index: 4
Last. Melinda A. Beck (UNC: University of North Carolina at Chapel Hill)H-Index: 36
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3 CitationsSource
#1Yazan Alwarawrah (Duke University)H-Index: 4
#2Amanda G. Nichols (Duke University)H-Index: 10
Last. Nancie J. MacIver (Duke University)H-Index: 13
view all 4 authors...
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#1Kaitlin Kiernan (Duke University)H-Index: 1
#2Nancie J. MacIver (Duke University)H-Index: 13
In this issue of Immunity, Sestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response of CD8+ T cells. Interestingly, this leads to persistent glucose intolerance and the progression of type 2 diabetes in pre-diabetic animals.
1 CitationsSource
#1Yazan Alwarawrah (Duke University)H-Index: 4
#2Kaitlin Kiernan (Duke University)H-Index: 1
Last. Nancie J. MacIver (Duke University)H-Index: 13
view all 3 authors...
Immune cell function and metabolism are closely linked. Many studies have now clearly demonstrated that alterations in cellular metabolism influence immune cell function and that, conversely, immune cell function determines the cellular metabolic state. Less well understood, however, are the effects of systemic metabolism or whole organism nutritional status on immune cell function and metabolism. Several studies have demonstrated that undernutrition is associated with immunosuppression, which l...
11 CitationsSource
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