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Pavle J. Randjelović
University of Niš
ChemistryEssential oilBiochemistryMedicinePharmacology
56Publications
12H-index
408Citations
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Publications 56
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#2Niko S. Radulović (University of Niš)H-Index: 26
Last. Sonja IlićH-Index: 4
view all 7 authors...
In this work we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4-(alkylamino)-3-nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec-butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100 mg kg-1, were evaluated in light/dark, open-field, horizontal wire and diazepam-induced sleep model...
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#1Pavle J. Randjelović (University of Niš)H-Index: 12
#2Nenad Stojiljković (University of Niš)H-Index: 11
Last. Ivan R. Ilić (University of Niš)H-Index: 7
view all 5 authors...
BACKGROUND: Besides numerous advantages and commodities offered by smartphones, there are obvious unhealthy effects. The global trend of an increase in the frequency of usage of smartphones, that is, prolonged screen time, is closely related to problematic smartphone use. The aim of our study was to measure the level of problematic smartphone use in a student population through the assessment of the smartphone screen time and the determination of the student chronotype, as well as through the co...
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#1Pavle J. Randjelović (University of Niš)H-Index: 12
#2Nenad Stojiljković (University of Niš)H-Index: 11
Last. Sonja Ilić (University of Niš)H-Index: 4
view all 6 authors...
ABSTRACTAbout a third of adults have sleep problems, while in the student population this number is much higher due to a specific lifestyle. It has been shown that the use of devices with light-emi...
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#1Nikola M. Stojanović (University of Niš)H-Index: 11
#2Pavle J. Randjelović (University of Niš)H-Index: 12
Last. Niko S. Radulović (University of Niš)H-Index: 26
view all 8 authors...
Abstract Despite being renowned for its volatiles, the data on the toxicity of the essential oil of lemon balm (Melissa officinalis L., Lamiaceae) is rather limited compared to its solvent/water-soluble extractibles. In this study, the aerial parts essential oil of M. officinalis, with over 130 constituents identified herein, 26 of which detected for the first time, was investigated for acute oral toxicity in BALB/c mice. The oil, composed of predominantly monoterpene aldehydes, citronellal (21....
1 CitationsSource
#1Ivan R. Ilić (University of Niš)H-Index: 7
#2Vuka KaticH-Index: 6
Last. Ratko S. Ilić (University of Niš)H-Index: 1
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Background and objectives: Here we report a rare case of a pancreatic polypeptide-secreting tumour (PPoma) discovered by accident during an autopsy. These PPomas occur in less than 2% of all pancreatic neoplasms and are almost exclusively silent, i.e., they are non-functional. Symptoms arising from PPoma are due to its compression of surrounding tissue. Materials and methods: The autopsy was performed on a 68-year-old male diagnosed with multiple endocrine neoplasm type 1 (MEN1) due to the patie...
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#1Ivan R. Ilić (University of Niš)H-Index: 7
#2Nikola M. Stojanović (University of Niš)H-Index: 11
Last. Ratko S. Ilić (University of Niš)H-Index: 1
view all 8 authors...
Background and objectives: The currently used immunohistochemical approach in determining the estrogen receptor (ER) positivity of breast cancers (BCs) is inherently subjective and additionally limited by its semi-quantitative nature. The application of software in the analysis of digitized slide images may overcome some of these limitations. However, the utilization of such an approach requires that the entire staining procedure is standardized. Background and objectives: We aimed to establish ...
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#1Niko S. Radulović (University of Niš)H-Index: 26
#2Marko Z. Mladenović (University of Niš)H-Index: 6
Last. Polina D. Blagojević (University of Niš)H-Index: 14
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Structural elucidation of a new triquinane sesquiterpenoid, presilphiperfolane-7α,8α-diol, 1a, isolated from Pulicaria vulgaris, was accomplished by combining solvent-induced removal of chemical shift degeneracy and computational (DFT-GIAO) prediction of NMR spectra with the analysis of 1H NMR splitting patterns. In addition to extensive NMR experiments (in 10 different solvents), MS, and FTIR, the identity of 1a was also confirmed by chemical transformations. The applied approach can facilitate...
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#1Ana B. Miltojević (University of Niš)H-Index: 9
#2Nikola M. Stojanović (University of Niš)H-Index: 11
Last. Niko S. Radulović (University of Niš)H-Index: 26
view all 4 authors...
Abstract Two volatile alkaloids, methyl (MMA) and isopropyl N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an effect on diazepam-induced sleep). In the continuation of our investigation of their urinary-metabolite profiles, we performed GC-MS analyses...
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#1Nikola M. Stojanović (University of Niš)H-Index: 11
#2Milica Stevanović (University of Niš)H-Index: 1
Last. Niko S. Radulović (University of Niš)H-Index: 26
view all 9 authors...
Abstract Carvacrol (5-isopropyl-2-methylphenol) is a biologically active monoterpene phenol abundantly present in the essential oils of many Lamiaceae aromatic/ethnomedicinal plants. Herein, we aimed to evaluate the damaging effect of carvacrol to rat pancreatic tissue, but also to assess its possible ameliorative impact on pancreatic damage induced by L-arginine. The toxic and beneficial (in a dose of 10 mg/kg) properties of carvacrol were assessed by measuring serum α-amylase and lipase activi...
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Background and objectives: The objective of this study was to determine if the angular photogrammetric analysis of soft-tissue characteristics can determine similarities between parents and their offspring in the Serbian population. Materials and Methods: A total of 15 families (52 participants) met the participation criteria of this study and their facial profile images were analyzed using the ImageJ software. Subjects were divided into groups of mothers and fathers and four groups of children ...
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