Harvey A. Risch
Yale University
CancerOvarian cancerPopulationMedicineBiology
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Publications 424
#1Dylan M. Glubb (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 15
#2Deborah J. Thompson (University of Cambridge)H-Index: 49
Last. Andrew Berchuck (Duke University)H-Index: 86
view all 152 authors...
Accumulating evidence suggests a relationship between endometrial cancer and epithelial ovarian cancer. For example, endometrial cancer and epithelial ovarian cancer share epidemiological risk factors and molecular features observed across histotypes are held in common (e.g. serous, endometrioid and clear cell). Independent genome-wide association studies (GWAS) for endometrial cancer and epithelial ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap betwee...
#1Ana Babic (Harvard University)H-Index: 12
#2Naoko Sasamoto (Brigham and Women's Hospital)H-Index: 3
Last. Renée T. Fortner (DKFZ: German Cancer Research Center)H-Index: 16
view all 31 authors...
Importance Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs by histotype is unclear. Furthermore, the observed associations between duration and timing of breastfeeding with ovarian cancer risk have been inconsistent. Objective To determine the association between breastfeeding (ie, ever/never, duration, timing) and ovarian can...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, and epidemiological studies have suggested positive associations with iron and red meat intake. Rare mutations in genes involved in the hepcidin-regulating pathway are known to cause iron overload and hemochromatosis. We hypothesize that the hepcidin-regulating pathway as characterized by common variants from genome-wide association studies will be associated with PDAC. Methods: We conducted a large pathway-based meta-analysis of...
#1Yi ShenH-Index: 7
#2Harvey A. RischH-Index: 73
Last. Robert S. BrownH-Index: 79
view all 15 authors...
HCC incidence has been continuously rising in the US for the past 30 years. To understand the increase in HCC risk, we conducted a case–control study in Connecticut, New Jersey and part of New York City. Through rapid case ascertainment and random digit dialing, we recruited 673 incident HCC patients and 1,166 controls. Information on demographic and anthropometric characteristics, lifestyle factors, medical and family cancer histories, were ascertained through telephone interviews using a struc...
Last. M Hidalgo (Cornell University)
view all 77 authors...
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To-date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Here, we complemented a classical new PC GWAS (1D) with spatial autocorrelation analysis (2D) and Hi-C maps (3D) to gain additional insight into the inherited basis of PC. In-silico functional analysis of public genomic information allowed prioritization of poten...
#1Stephen Cristiano (Johns Hopkins University)H-Index: 4
#2David J. McKean (Johns Hopkins University)H-Index: 1
Last. Manal M. Hassan (University of Texas MD Anderson Cancer Center)H-Index: 50
view all 24 authors...
Germline copy number variants (CNVs) increase risk for many diseases, yet detection of CNVs and quantifying their contribution to disease risk in large-scale studies is challenging. We developed an approach called CNPBayes to identify latent batch effects, to provide probabilistic estimates of integer copy number across the estimated batches, and to fully integrate the copy number uncertainty in the association model for disease. We demonstrate this approach in a Pancreatic Cancer Case Control s...
#1Jun Zhong (NIH: National Institutes of Health)H-Index: 1
#2Ashley Jermusyk (NIH: National Institutes of Health)H-Index: 2
Last. Laufey Amundadottir (NIH: National Institutes of Health)H-Index: 34
view all 95 authors...
BACKGROUND: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies (GWAS) in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study (TWAS) in Europeans using three approaches, FUSION, MetaXcan and SMulTiXcan. We integrated GW...
2 CitationsSource
#1Yuanyuan Xiao (Kunming Medical University)
#2Liping He (Kunming Medical University)
Last. Harvey A. Risch (Yale University)H-Index: 73
view all 9 authors...
Abstract Purpose This population-based cross-sectional study described self-harm (SH) behaviors and associated factors in 2,898 Chinese left-behind children (LBC). Methods Descriptive statistics were used to present and compare the distributional characteristics of SH behaviors. Binary and ordinal logistic-regression models for survey data were applied to explore associated factors of SH. Results Among the LBC, 48% (95%CI: 42%-54%) reported SH behaviors. SH was prominently associated with suicid...
#1Laura Fachal (University of Cambridge)H-Index: 20
#2Hugues Aschard (Harvard University)H-Index: 21
Last. Alison M. Dunning (University of Cambridge)H-Index: 81
view all 341 authors...
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched gen...
5 CitationsSource
#1Yuanyuan Xiao (Kunming Medical University)
#2Yeying Wang (Kunming Medical University)H-Index: 1
Last. Harvey A. Risch (Yale University)H-Index: 73
view all 6 authors...
Abstract Psychological resilience of Chinese left-behind children (LBC) remains under-studied. In this cross-sectional survey, we intended to analyze factors associated with resilience in a large group of LBC. One-stage random cluster sampling was used to select 2898 LBC aged between 10 and 17 years in Yunnan province of southwestern China. Face-to-face interview was used to collect relevant information from the participants. Resilience was measured by the Resilience Scale for Chinese Adolescent...