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Ioanna Ntalla
Queen Mary University of London
Genome-wide association studyGenetic associationGeneticsLocus (genetics)Biology
85Publications
28H-index
2,800Citations
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Publications 94
Newest
#1Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 28
#2Lu-Chen Weng (Broad Institute)H-Index: 17
Last. Michael R. Barnes (NIHR: National Institute for Health Research)H-Index: 36
view all 187 authors...
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment ...
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#1L. de las Fuentes (WashU: Washington University in St. Louis)H-Index: 1
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 23
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
1 CitationsSource
#1Melissa A. Munn-Chernoff (UNC: University of North Carolina at Chapel Hill)H-Index: 10
#2Emma C. Johnson (WashU: Washington University in St. Louis)H-Index: 3
Last. Scott D. Gordon (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 41
view all 352 authors...
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenoty...
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#2Emma C. JohnsonH-Index: 3
Last. Scott D. GordonH-Index: 41
view all 352 authors...
#1Shuyang Yao (KI: Karolinska Institutet)H-Index: 5
#2Ralf Kuja-Halkola (KI: Karolinska Institutet)H-Index: 22
Last. Henrik Larsson (Örebro University)H-Index: 58
view all 215 authors...
Abstract Background Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. Methods We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined...
2 CitationsSource
#1Catherine John (University of Leicester)H-Index: 5
#2Nicola F. Reeve (University of Leicester)H-Index: 3
Last. Martin D. Tobin (University of Leicester)H-Index: 54
view all 28 authors...
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#1Melissa A. Munn-Chernoff (UNC: University of North Carolina at Chapel Hill)H-Index: 10
#2Emma C. Johnson (WashU: Washington University in St. Louis)H-Index: 3
Last. Arpana Agrawal (WashU: Washington University in St. Louis)H-Index: 50
view all 352 authors...
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phen...
1 CitationsSource
#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last. Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
Source
#1Lixia Zeng (TUM: Technische Universität München)H-Index: 15
#2Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 28
Last. Heribert Schunkert (TUM: Technische Universität München)H-Index: 104
view all 10 authors...
3 CitationsSource
#1Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 28
#2Lu-Chen Weng (Harvard University)H-Index: 17
Last. Patricia B. Munroe (QMUL: Queen Mary University of London)H-Index: 74
view all 187 authors...
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. We performed multi-ancestry (N=293,051) and European only (N=271,570) genome-wide association (GWAS) meta-analyses for the PR interval, discovering 210 loci of which 149 are novel. Variants at all loci nearly doubled the percentage of heritability explained, from 33.5% to 62.6%. We observed enri...
Source
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