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Kazuaki Chayama
Hiroshima University
VirologyDiabetes mellitusGeneral surgeryMedicineGastroenterology
1,707Publications
90H-index
39.8kCitations
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Publications 1697
Newest
#1Kazutaka KurokiH-Index: 3
#2Shiro OkaH-Index: 37
Last. Kazuaki ChayamaH-Index: 90
view all 9 authors...
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#1Ko Oshita (Hiroshima University)
#2Masahiro Ohira (Hiroshima University)H-Index: 11
Last. Kazuaki Chayama (Hiroshima University)H-Index: 90
view all 11 authors...
BACKGROUND Although balloon-occluded retrograde transvenous obliteration (BRTO) is often selected to treat gastric varices caused by portal hypertension, data comparing BRTO and splenectomy with gastric devascularization (Sp + Dev) are limited. METHODS From January 2009 to February 2018, 100 patients with gastric varices caused by portal hypertension who underwent Sp + Dev (n = 45) or BRTO (n = 55) were included. Overall survival (OS) and the rebleeding rate were calculated using the inverse pro...
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#1Kumada TakashiH-Index: 44
#2Toyoda HidenoriH-Index: 44
Last. Philip J. Johnson (University of Liverpool)H-Index: 83
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BACKGROUND We conducted a prospective study using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) to determine whether sustained virological response (SVR) by direct-acting anti-viral (DAA) drugs suppresses hepatocarcinogenesis in patients with hepatitis C virus (HCV) infection. AIM To use serial Gd-EOB-MRI to assess the impact of DAAs on hepatocarcinogenesis. METHODS Between February 2008 and December 2018, 1083 consecutive patients w...
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#1Yasue Takeuchi (Hiroshima University)
#2Masataka Tsuge (Hiroshima University)H-Index: 30
Last. Eisuke Murakami (Hiroshima University)H-Index: 16
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BACKGROUND HBx associates with hepatocellular carcinogenesis via the induction of malignant transformation and mitochondrial dysfunction. However, the association between HBx and histone methyltransferase in carcinogenesis has not been fully clarified. In this study, we analyzed the association between HBx and the histone methyltransferase SUV39h1 using HBV replication models. METHODS We constructed several HBx and SUV39h1 expression plasmids and analyzed the association between HBx and SUV39h1 ...
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#1Norimasa Araki (Saga University)H-Index: 1
#2Hirokazu Takahashi (Saga University)H-Index: 8
Last. Kazuaki Chayama (Hiroshima University)H-Index: 90
view all 12 authors...
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#1Kazuyoshi IshigakiH-Index: 11
#2Masato Akiyama (Kyushu University)H-Index: 9
Last. Yukinori OkadaH-Index: 50
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The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals across 42 diseases. We detected 320 independent signals in 276 loci for 27 diseases, with 25 novel loci (P < 9.58 × 10−9). East Asian–specific missense variants were identified as candidate causal variants for three novel loci, and we successfully replicated t...
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#1Takuya Kuwashiro (Saga University)H-Index: 2
#2Hirokazu Takahashi (Saga University)H-Index: 8
Last. Yuichiro Eguchi (Saga University)H-Index: 29
view all 17 authors...
Background Liver biopsy has been the standard procedure for diagnosing and evaluating the severity of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); however, interobserver discordance remains a critical issue in its pathological diagnosis. Methods and Results We examined the concordance rates of pathological scoring and diagnosis between pathologists at individual institutions (local diagnosis) and two central pathologists specialized in liver pathology (cent...
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#1Sumio Iio (Hiroshima University)H-Index: 3
#2Shiro Oka (Hiroshima University)H-Index: 37
Last. Kazuaki Chayama (Hiroshima University)H-Index: 90
view all 6 authors...
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#1Kenta MatsumotoH-Index: 1
#2Yuji UrabeH-Index: 15
Last. Kazuaki ChayamaH-Index: 90
view all 7 authors...
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#1Yosuke Tamura (Hiroshima University)
#2Tomokazu Kawaoka (Hiroshima University)H-Index: 25
Last. Kazuaki ChayamaH-Index: 90
view all 18 authors...
A 76-year-old man was diagnosed with multiple hepatocellular carcinomas (HCCs). He underwent right lobectomy and partial resection of the liver after transcatheter arterial embolization at our hospital. The pathology report was moderately differentiated HCC (fT4N0M0 Stage Iva, Vp1, Vv0). Follow-up CT revealed a lesion in the right ventricle 3 years after surgery. Moderately differentiated HCC was determined on myocardial biopsy, and the lesion was diagnosed as cardiac metastasis of HCC. No recur...
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