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Kathie A. Mihindukulasuriya
Washington University in St. Louis
17Publications
14H-index
5,384Citations
Publications 17
Newest
Laura Ibanez5
Estimated H-index: 5
(Washington University in St. Louis),
Fabiana H.G. Farias2
Estimated H-index: 2
(Washington University in St. Louis),
Umber Dube3
Estimated H-index: 3
(Washington University in St. Louis)
... more
Purpose of the Review This review summarizes the current state of the art of polygenic risk scores (PRSs) in the assessment of risk for neurodegenerative diseases.
Source Cite
Yanjiao Zhou21
Estimated H-index: 21
(Washington University in St. Louis),
Kristine M. Wylie20
Estimated H-index: 20
(Washington University in St. Louis),
Rana E. El Feghaly1
Estimated H-index: 1
(University of Mississippi Medical Center)
... more
ABSTRACT The potential to rapidly capture the entire microbial community structure and/or gene content makes metagenomic sequencing an attractive tool for pathogen identification and the detection of resistance/virulence genes in clinical settings. Here, we assessed the consistency between PCR from a diagnostic laboratory, quantitative PCR (qPCR) from a research laboratory, 16S rRNA gene sequencing, and metagenomic shotgun sequencing (MSS) for Clostridium difficile identification in diarrhea sto...
19 Citations Download PDF Cite
2015 in Mbio [IF: 9.13]
M. Isabel Ordiz8
Estimated H-index: 8
(University of Washington),
Thaddaeus May3
Estimated H-index: 3
(Baylor College of Medicine),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(University of Washington)
... more
Background Resistant starch (RS) decreases intestinal inflammation in some settings. We tested the hypothesis that gut inflammation will be reduced with dietary supplementation with RS in rural Malawian children. Eighteen stunted 3–5-year-old children were supplemented with 8.5 g/day of RS type 2 for 4 weeks. The fecal samples were analyzed for the microbiota, the microbiome, short chain fatty acids, metabolome, and proteins indicative of inflammation before and after the intervention. Subjects ...
21 Citations Source Cite
2014 in BMC Biology [IF: 5.77]
Kristine M. Wylie20
Estimated H-index: 20
(Washington University in St. Louis),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(Washington University in St. Louis),
Yanjiao Zhou21
Estimated H-index: 21
(Washington University in St. Louis)
... more
Background The Human Microbiome Project (HMP) was undertaken with the goal of defining microbial communities in and on the bodies of healthy individuals using high-throughput metagenomic sequencing analysis. The viruses present in these microbial communities, the `human virome,’ are an important aspect of the human microbiome that is particularly understudied in the absence of overt disease. We analyzed eukaryotic double-stranded DNA (dsDNA) viruses, together with dsDNA replicative intermediates...
61 Citations Download PDF Cite
2014 in Genome Biology [IF: 13.21]
Yanjiao Zhou21
Estimated H-index: 21
(University of Washington),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(University of Washington),
Hongyu Gao1
Estimated H-index: 1
(Indiana University)
... more
Background: Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities in stool, nasal, skin, vaginal and oral habitats in a healthy cohort of 236 subjects from the Human Microbiome Project. Results: We iden...
35 Citations Download PDF Cite
2013 in Genome Biology [IF: 13.21]
Yanjiao Zhou21
Estimated H-index: 21
(Washington University in St. Louis),
Hongyu Gao9
Estimated H-index: 9
(Washington University in St. Louis),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(Washington University in St. Louis)
... more
Background Characterizing the biogeography of the microbiome of healthy humans is essential for understanding microbial associated diseases. Previous studies mainly focused on a single body habitat from a limited set of subjects. Here, we analyzed one of the largest microbiome datasets to date and generated a biogeographical map that annotates the biodiversity, spatial relationships, and temporal stability of 22 habitats from 279 healthy humans.
143 Citations Source Cite
Yanjiao Zhou21
Estimated H-index: 21
,
Hongyu Gao1
Estimated H-index: 1
,
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
Jens H. Kuhn39
Estimated H-index: 39
,
Sadia Bekal11
Estimated H-index: 11
,
Yíngyún Caì8
Estimated H-index: 8
... more
Source
2013 in Archives of Virology [IF: 2.16]
Jens H. Kuhn39
Estimated H-index: 39
(National Institutes of Health),
Sadia Bekal11
Estimated H-index: 11
(University of Illinois at Urbana–Champaign),
Yíngyún Caì8
Estimated H-index: 8
(National Institutes of Health)
... more
Nyamanini virus (NYMV) and Midway virus (MIDWV) are unclassified tick-borne agents that infect land birds and seabirds, respectively. The recent molecular characterization of both viruses confirmed their already known close serological relationship and revealed them to be nonsegmented, single- and negative-stranded RNA viruses that are clearly related to, but quite distinct from, members of the order Mononegavirales (bornaviruses, filoviruses, paramyxoviruses, and rhabdoviruses). A third agent, ...
20 Citations Source Cite
2012 in Nature [IF: 41.58]
Curtis Huttenhower64
Estimated H-index: 64
(Broad Institute),
Dirk Gevers61
Estimated H-index: 61
(Broad Institute),
Rob Knight134
Estimated H-index: 134
(University of Colorado Boulder)
... more
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.
3,555 Citations Download PDF Cite
12