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Kathie A. Mihindukulasuriya
Washington University in St. Louis
MicrobiomeHuman Microbiome ProjectGeneticsBiologyHuman microbiome
34Publications
16H-index
7,739Citations
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Publications 33
Newest
#1Chengran Yang (WashU: Washington University in St. Louis)H-Index: 4
#2Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 7
Last. John P. Budde (WashU: Washington University in St. Louis)H-Index: 23
view all 21 authors...
Expression quantitative trait loci (eQTL) mapping has successfully resolved some genome-wide association study (GWAS) loci for complex traits. However, there is a need for implementing additional "omic" approaches to untangle additional loci and provide a biological context for GWAS signals. We generated a detailed landscape of the genomic architecture of protein levels in multiple neurologically relevant tissues (brain, cerebrospinal fluid (CSF) and plasma), by profiling thousands of proteins i...
Source
#1Bruce A. Rosa (WashU: Washington University in St. Louis)H-Index: 17
#2Kathie A. Mihindukulasuriya (WashU: Washington University in St. Louis)H-Index: 16
Last. Makedonka Mitreva (WashU: Washington University in St. Louis)H-Index: 2
view all 10 authors...
ABSTRACT Whole-genome bacterial sequences are required to better understand microbial functions, niche-specific bacterial metabolism, and disease states. Although genomic sequences are available for many of the human-associated bacteria from commonly tested body habitats (e.g., feces), as few as 13% of bacterium-derived reads from other sites such as the skin map to known bacterial genomes. To facilitate a better characterization of metagenomic shotgun reads from underrepresented body sites, we ...
Source
#1Zeran Li (WashU: Washington University in St. Louis)H-Index: 7
#2Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 7
Last. Carlos Cruchaga (WashU: Washington University in St. Louis)H-Index: 54
view all 24 authors...
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex. The goal of this study is to investigate genetic factors associated with the neuronal proportion in health and disease. To identify cell-autonomous genetic variants associated with neuronal proportion in cortical tissues, we inferred cellular population structure from bulk RNA-Seq derived from 1536 indivi...
3 CitationsSource
#1Bruce A. Rosa (UW: University of Washington)H-Index: 17
#1Bruce A Rosa (UW: University of Washington)
Last. Makedonka Mitreva (UW: University of Washington)H-Index: 2
view all 10 authors...
Whole genome bacterial sequences are required to better understand microbial functions, niche-specific bacterial metabolism, and disease states. Although genomic sequences are available for many of the human-associated bacteria from commonly tested body habitats (e.g. stool), as few as 13% of bacterial-derived reads from other sites such as the skin map to known bacterial genomes. To facilitate a better characterization of metagenomic shotgun reads from under-represented body sites, we collected...
Source
#1Jorge L. Del-Aguila (WashU: Washington University in St. Louis)H-Index: 14
#2Zeran Li (WashU: Washington University in St. Louis)H-Index: 7
Last. Oscar HarariH-Index: 14
view all 18 authors...
Alzheimer’s disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. Using bulk RNA-seq from the parietal lobes and deconvolution methods, we previously reported that brains exhibiting different AD genetic architecture exhibit different cellular proportions. Here, we sou...
14 CitationsSource
#1Zeran Li (WashU: Washington University in St. Louis)H-Index: 7
#2Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 7
Last. Carlos CruchagaH-Index: 54
view all 19 authors...
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#1Jorge Alberto Bahena (WashU: Washington University in St. Louis)H-Index: 1
#2Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 7
Last. Oscar HarariH-Index: 14
view all 6 authors...
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#1James Perez (WashU: Washington University in St. Louis)H-Index: 1
#2Kathie A. Mihindukulasuriya (WashU: Washington University in St. Louis)H-Index: 16
Last. Oscar HarariH-Index: 14
view all 8 authors...
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#1Victoria Fernandez (WashU: Washington University in St. Louis)H-Index: 1
#2Jorge L. Del-Aguila (WashU: Washington University in St. Louis)H-Index: 14
Last. Carlos CruchagaH-Index: 54
view all 14 authors...
Source
#1Jorge L. Del-Aguila (WashU: Washington University in St. Louis)H-Index: 14
#2Bruno A. Benitez (WashU: Washington University in St. Louis)H-Index: 20
Last. Carlos CruchagaH-Index: 54
view all 15 authors...
Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has three different alternative transcripts, but most of the functional studies only model the longest transcript. No studies have analyzed TREM2 expression levels or alternative splicing in brains from AD and cogniti...
6 CitationsSource
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