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Kathie A. Mihindukulasuriya
Washington University in St. Louis
15Publications
10H-index
5,206Citations
Publications 15
Newest
Yanjiao Zhou10
Estimated H-index: 10
(Washington University in St. Louis),
Kristine M. Wylie10
Estimated H-index: 10
(Washington University in St. Louis),
Rana E. El Feghaly1
Estimated H-index: 1
(University of Mississippi Medical Center)
... more
The potential to rapidly capture the entire microbial community structure and/or gene content makes metagenomic sequencing an attractive tool for pathogen identification and the detection of resistance/virulence genes in clinical settings. Here, we assessed the consistency between PCR from a diagnostic laboratory, quantitative PCR (qPCR) from a research laboratory, 16S rRNA gene sequencing, and metagenomic shotgun sequencing (MSS) for Clostridium difficile identification in diarrhea stool sample...
Ref 36Cited 14 Download Pdf Cite this paper
2015 in mbio
M Isabel Ordiz6
Estimated H-index: 6
(University of Washington),
Thaddaeus May3
Estimated H-index: 3
(Baylor College of Medicine),
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
(University of Washington)
... more
Background Resistant starch (RS) decreases intestinal inflammation in some settings. We tested the hypothesis that gut inflammation will be reduced with dietary supplementation with RS in rural Malawian children. Eighteen stunted 3–5-year-old children were supplemented with 8.5 g/day of RS type 2 for 4 weeks. The fecal samples were analyzed for the microbiota, the microbiome, short chain fatty acids, metabolome, and proteins indicative of inflammation before and after the intervention. Subjects ...
Ref 44Cited 20 Download Pdf Cite this paper
2014 in bmc biology [IF: 6.78]
Kristine M. Wylie10
Estimated H-index: 10
(Washington University in St. Louis),
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
(Washington University in St. Louis),
Yanjiao Zhou10
Estimated H-index: 10
(Washington University in St. Louis)
... more
Background: The Human Microbiome Project (HMP) was undertaken with the goal of defining microbial communities in and on the bodies of healthy individuals using high-throughput metagenomic sequencing analysis. The viruses present in these microbial communities, the ‘human virome,’ are an important aspect of the human microbiome that is particularly understudied in the absence of overt disease. We analyzed eukaryotic double-stranded DNA (dsDNA) viruses, together with dsDNA replicative intermediate...
Ref 37Cited 60 Download Pdf Cite this paper
Yanjiao Zhou10
Estimated H-index: 10
(University of Washington),
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
(University of Washington),
Hongyu Gao1
Estimated H-index: 1
(Indiana University)
... more
Background Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities in stool, nasal, skin, vaginal and oral habitats in a healthy cohort of 236 subjects from the Human Microbiome Project.
Ref 49Cited 33 Download Pdf Cite this paper
Yanjiao Zhou10
Estimated H-index: 10
(Washington University in St. Louis),
Hongyu Gao9
Estimated H-index: 9
(Washington University in St. Louis),
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
(Washington University in St. Louis)
... more
Background Characterizing the biogeography of the microbiome of healthy humans is essential for understanding microbial associated diseases. Previous studies mainly focused on a single body habitat from a limited set of subjects. Here, we analyzed one of the largest microbiome datasets to date and generated a biogeographical map that annotates the biodiversity, spatial relationships, and temporal stability of 22 habitats from 279 healthy humans.
Ref 52Cited 140 Download Pdf Cite this paper
Yanjiao Zhou10
Estimated H-index: 10
,
Hongyu Gao1
Estimated H-index: 1
,
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
Ref 50 Source
2013 in archives of virology [IF: 2.06]
Jens H. Kuhn7
Estimated H-index: 7
(National Institutes of Health),
Sadia Bekal10
Estimated H-index: 10
(University of Illinois at Urbana–Champaign),
Yíngyún Caì7
Estimated H-index: 7
(National Institutes of Health)
... more
Nyamanini virus (NYMV) and Midway virus (MIDWV) are unclassified tick-borne agents that infect land birds and seabirds, respectively. The recent molecular characterization of both viruses confirmed their already known close serological relationship and revealed them to be nonsegmented, single- and negative-stranded RNA viruses that are clearly related to, but quite distinct from, members of the order Mononegavirales (bornaviruses, filoviruses, paramyxoviruses, and rhabdoviruses). A third agent, ...
Ref 63Cited 20 Download Pdf Cite this paper
2012 in nature [IF: 40.14]
Curtis Huttenhower9
Estimated H-index: 9
(Broad Institute),
Dirk Gevers10
Estimated H-index: 10
(Broad Institute),
Rob Knight10
Estimated H-index: 10
(Howard Hughes Medical Institute)
... more
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.
Ref 18Cited 3416 Download Pdf Cite this paper
2012 in plos one
Kristine M. Wylie10
Estimated H-index: 10
(Washington University in St. Louis),
Kathie A. Mihindukulasuriya10
Estimated H-index: 10
(Washington University in St. Louis),
Erica Sodergren10
Estimated H-index: 10
(Washington University in St. Louis)
... more
Unexplained fever (UF) is a common problem in children under 3 years old. Although virus infection is suspected to be the cause of most of these fevers, a comprehensive analysis of viruses in samples from children with fever and healthy controls is important for establishing a relationship between viruses and UF. We used unbiased, deep sequencing to analyze 176 nasopharyngeal swabs (NP) and plasma samples from children with UF and afebrile controls, generating an average of 4.6 million sequences...
Ref 29Cited 91 Download Pdf Cite this paper
2012 in nature [IF: 40.14]
Barbara A. Methé5
Estimated H-index: 5
(J. Craig Venter Institute),
Karen E. Nelson8
Estimated H-index: 8
(J. Craig Venter Institute),
Mihai Pop10
Estimated H-index: 10
(University of Maryland, College Park)
... more
The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.
Ref 15Cited 1021 Download Pdf Cite this paper
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