Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Kathie A. Mihindukulasuriya
Washington University in St. Louis
19Publications
14H-index
5,831Citations
Publications 19
Newest
Published on Dec 1, 2019in Molecular Neurodegeneration 8.27
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Bruno A. Benitez15
Estimated H-index: 15
(WashU: Washington University in St. Louis)
+ 12 AuthorsShan Jiang1
Estimated H-index: 1
(WashU: Washington University in St. Louis)
Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has three different alternative transcripts, but most of the functional studies only model the longest transcript. No studies have analyzed TREM2 expression levels or alternative splicing in brains from AD and cogniti...
1 Citations Source Cite
Published on Mar 30, 2019in bioRxiv
Jorge L. Del-Aguila8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Zeran Li2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
+ 15 AuthorsFengxian Wang (WashU: Washington University in St. Louis)
Alzheimer Disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis specifically in the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. We previously reported different cellular proportions between brains exhibiting different AD genetic architecture, that we identified using bulk RNA-seq from homogenized parietal lobes and deconvolution met...
Source Cite
Published on Mar 20, 2019in bioRxiv
Zeran Li2
Estimated H-index: 2
,
F. G. Farias + 17 AuthorsJohn Budde21
Estimated H-index: 21
(WashU: Washington University in St. Louis)
Background: In previous studies, we observed decreased neuronal and increased astrocyte proportions in AD cases in parietal brain cortex by using a deconvolution method for bulk RNA-seq. These findings suggested that genetic risk factors associated with AD etiology have a specific effect in the cellular composition of AD brains. The goal of this study is to investigate if there are genetic determinants for brain cell compositions. Methods: Using cell type composition inferred from transcriptome ...
Source Cite
Published on Mar 1, 2019in Current Genetic Medicine Reports
Laura Ibanez7
Estimated H-index: 7
(WashU: Washington University in St. Louis),
Fabiana H. G. Farias9
Estimated H-index: 9
(WashU: Washington University in St. Louis)
+ 2 AuthorsOscar Harari13
Estimated H-index: 13
(WashU: Washington University in St. Louis)
Purpose of the Review This review summarizes the current state of the art of polygenic risk scores (PRSs) in the assessment of risk for neurodegenerative diseases.
Source Cite
Published on Feb 1, 2016in Journal of Clinical Microbiology 4.96
Yanhua Zhou32
Estimated H-index: 32
(WashU: Washington University in St. Louis),
Kristine M. Wylie23
Estimated H-index: 23
(WashU: Washington University in St. Louis)
+ 5 AuthorsGeorge M. Weinstock98
Estimated H-index: 98
(UMMC: University of Mississippi Medical Center)
ABSTRACT The potential to rapidly capture the entire microbial community structure and/or gene content makes metagenomic sequencing an attractive tool for pathogen identification and the detection of resistance/virulence genes in clinical settings. Here, we assessed the consistency between PCR from a diagnostic laboratory, quantitative PCR (qPCR) from a research laboratory, 16S rRNA gene sequencing, and metagenomic shotgun sequencing (MSS) for Clostridium difficile identification in diarrhea sto...
23 Citations Source Cite
Published on Dec 1, 2015in Mbio 6.75
M. Isabel Ordiz8
Estimated H-index: 8
(UW: University of Washington),
Thaddaeus May3
Estimated H-index: 3
(BCM: Baylor College of Medicine)
+ 10 AuthorsKen Maleta13
Estimated H-index: 13
Background Resistant starch (RS) decreases intestinal inflammation in some settings. We tested the hypothesis that gut inflammation will be reduced with dietary supplementation with RS in rural Malawian children. Eighteen stunted 3–5-year-old children were supplemented with 8.5 g/day of RS type 2 for 4 weeks. The fecal samples were analyzed for the microbiota, the microbiome, short chain fatty acids, metabolome, and proteins indicative of inflammation before and after the intervention. Subjects ...
23 Citations Source Cite
Published on Dec 1, 2014in BMC Biology 6.72
Kristine M. Wylie23
Estimated H-index: 23
(WashU: Washington University in St. Louis),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(WashU: Washington University in St. Louis)
+ 3 AuthorsGeorge M. Weinstock98
Estimated H-index: 98
(WashU: Washington University in St. Louis)
Background: The Human Microbiome Project (HMP) was undertaken with the goal of defining microbial communities in and on the bodies of healthy individuals using high-throughput metagenomic sequencing analysis. The viruses present in these microbial communities, the ‘human virome,’ are an important aspect of the human microbiome that is particularly understudied in the absence of overt disease. We analyzed eukaryotic double-stranded DNA (dsDNA) viruses, together with dsDNA replicative intermediate...
69 Citations Source Cite
Published on Jan 1, 2014in Genome Biology 14.03
Yanhua Zhou32
Estimated H-index: 32
(UW: University of Washington),
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
(UW: University of Washington)
+ 8 AuthorsErica Sodergren11
Estimated H-index: 11
(University of Connecticut Health Center)
Background Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities in stool, nasal, skin, vaginal and oral habitats in a healthy cohort of 236 subjects from the Human Microbiome Project.
38 Citations Source Cite
Published on Oct 1, 2013in Archives of Virology 2.26
Jens H. Kuhn41
Estimated H-index: 41
(NIH: National Institutes of Health),
Sadia Bekal12
Estimated H-index: 12
(UIUC: University of Illinois at Urbana–Champaign)
+ 16 AuthorsKathie A. Mihindukulasuriya14
Estimated H-index: 14
(WashU: Washington University in St. Louis)
Nyamanini virus (NYMV) and Midway virus (MIDWV) are unclassified tick-borne agents that infect land birds and seabirds, respectively. The recent molecular characterization of both viruses confirmed their already known close serological relationship and revealed them to be nonsegmented, single- and negative-stranded RNA viruses that are clearly related to, but quite distinct from, members of the order Mononegavirales (bornaviruses, filoviruses, paramyxoviruses, and rhabdoviruses). A third agent, ...
22 Citations Source Cite
Published on Jan 1, 2013
Yanhua Zhou32
Estimated H-index: 32
,
Hongyu Gao1
Estimated H-index: 1
,
Kathie A. Mihindukulasuriya14
Estimated H-index: 14
123