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Michael Ristow
École Polytechnique Fédérale de Lausanne
178Publications
50H-index
11.4kCitations
Publications 178
Newest
#1Peer Aramillo Irizar (CAU: University of Kiel)H-Index: 1
#2Sascha Schäuble (FSU: University of Jena)H-Index: 10
Last.Uwe Menzel (Leibniz Association)H-Index: 6
view all 28 authors...
The original version of this Article contained an error in the spelling of the author Jule Muller, which was incorrectly given as Julia Muller. Additionally, in Fig. 4a, the blue-red colour scale for fold change in ageing/disease regulation included a blue stripe in place of a red stripe at the right-hand end of the scale. These errors have been corrected in both the PDF and HTML versions of the Article.
#1Andy Wai Kan Yeung (HKU: University of Hong Kong)H-Index: 9
#2Nikolay T. Tzvetkov (BAS: Bulgarian Academy of Sciences)H-Index: 9
Last.Jianbo Xiao (UM: University of Macau)H-Index: 33
view all 37 authors...
Abstract Biotechnology is an evolving research field that covers a broad range of topics. Here we aimed to evaluate the latest research literature, to identify prominent research themes, major contributors in terms of institutions, countries/regions, and journals. The Web of Science Core Collection online database was searched to retrieve biotechnology articles published since 2017. In total, 12,351 publications were identified and analyzed. Over 8,500 institutions contributed to these biotechno...
#1Misa HiroseH-Index: 15
#2Paul SchilfH-Index: 5
Last.Jan RuppH-Index: 29
view all 15 authors...
Mitochondrial complex I—the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery—has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants is ...
#1Peer Aramillo Irizar (CAU: University of Kiel)H-Index: 1
#2Sascha Schäuble (FSU: University of Jena)H-Index: 10
Last.Uwe Menzel (Leibniz Association)H-Index: 6
view all 28 authors...
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories ...
#1Misa Hirose (University of Lübeck)H-Index: 15
#2Paul Schilf (University of Lübeck)H-Index: 5
Last.Andreas ZieglerH-Index: 78
view all 30 authors...
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain carrying the mitochondrial genome of an AKR/J mouse str...
#1Misa HiroseH-Index: 15
#2Paul SchilfH-Index: 5
Last.Jan RuppH-Index: 29
view all 15 authors...
Mitochondrial complex I, the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery, has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA-encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants i...
#1Meenakshi Ravichandran (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Steffen Priebe (Leibniz Association)H-Index: 16
Last.Michael Ristow (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 50
view all 10 authors...
Summary Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. M...
#1Maximilian KleinertH-Index: 17
#2Christoffer Clemmensen (TUM: Technische Universität München)H-Index: 22
Last.Annette SchürmannH-Index: 44
view all 20 authors...
Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschop and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.
#1Jennifer L. Watts (WSU: Washington State University)H-Index: 26
#2Michael Ristow (ETH Zurich)H-Index: 50
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior. In this review, we outline lipid and carbohydrate structures as well as ...
#1Meenakshi Ravichandran (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Gerald GrandlH-Index: 4
Last.Michael Ristow (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 50
view all 3 authors...
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
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