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Michael Ristow
École Polytechnique Fédérale de Lausanne
174Publications
50H-index
11.4kCitations
Publications 174
Newest
Published on Dec 1, 2018in Nature Communications 12.35
Peer Aramillo Irizar1
Estimated H-index: 1
(University of Kiel),
Sascha Schäuble10
Estimated H-index: 10
(University of Jena)
+ 25 AuthorsUwe Menzel6
Estimated H-index: 6
(Leibniz Association)
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories ...
10 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Misa Hirose15
Estimated H-index: 15
(University of Lübeck),
Paul Schilf5
Estimated H-index: 5
(University of Lübeck)
+ 27 AuthorsAndreas Ziegler78
Estimated H-index: 78
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain carrying the mitochondrial genome of an AKR/J mouse str...
1 Citations Source Cite
Published on Nov 16, 2018in bioRxiv
Misa Hirose15
Estimated H-index: 15
,
Paul Schilf5
Estimated H-index: 5
+ 12 AuthorsJan Rupp29
Estimated H-index: 29
Mitochondrial complex I, the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery, has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA-encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants i...
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Published on Apr 1, 2018in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Steffen Priebe16
Estimated H-index: 16
(Leibniz Association)
+ 7 AuthorsMichael Ristow50
Estimated H-index: 50
(École Polytechnique Fédérale de Lausanne)
Summary Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. M...
5 Citations Source Cite
Published on Mar 1, 2018in Nature Reviews Endocrinology 20.27
Maximilian Kleinert17
Estimated H-index: 17
,
Christoffer Clemmensen22
Estimated H-index: 22
(Technische Universität München)
+ 17 AuthorsAnnette Schürmann44
Estimated H-index: 44
Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschop and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.
48 Citations Source Cite
Published on Oct 1, 2017in Genetics 4.08
Jennifer L. Watts26
Estimated H-index: 26
(Washington State University),
Michael Ristow50
Estimated H-index: 50
(ETH Zurich)
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior. In this review, we outline lipid and carbohydrate structures as well as ...
12 Citations Source Cite
Published on Oct 1, 2017in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Gerald Grandl4
Estimated H-index: 4
,
Michael Ristow50
Estimated H-index: 50
(École Polytechnique Fédérale de Lausanne)
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
2 Citations Source Cite
Published on Aug 1, 2017in Aging Cell 7.63
Troy L. Merry13
Estimated H-index: 13
(École Polytechnique Fédérale de Lausanne),
Doreen Kuhlow11
Estimated H-index: 11
(Schiller International University)
+ 5 AuthorsKim Zarse20
Estimated H-index: 20
(École Polytechnique Fédérale de Lausanne)
Summary Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/−) or homozygous (PerIRKO−/−) disruption of the IR in peripheral tissue of 15-weeks-old mice using a tamoxifen-inducible Cre transgenic mouse with only peripheral tissue expression, and subsequentl...
2 Citations Source Cite
Published on Jul 1, 2017in Free Radical Biology and Medicine 6.02
Michael Ristow50
Estimated H-index: 50
(ETH Zurich)
Processing and intermediate metabolism of macronutrients are essential components of any life. Facultative or obligatory conversion of carbohydrates as well as fatty and amino acids into readily available energy equivalents like ATP are tightly regulated. Our interest is focused on the role of specific amino acids and glucose metabolites on nematodal and murine lifespan. Downstream oxidative metabolism of fatty and amino acids, as well as glycolytic derivatives like pyruvate occurs in the mitoch...
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