Michael Ristow
École Polytechnique Fédérale de Lausanne
148Publications
47H-index
11.1kCitations
Publications 148
Newest
Published on Dec 1, 2018in Scientific Reports 4.12
Misa Hirose15
Estimated H-index: 15
(University of Lübeck),
Paul Schilf4
Estimated H-index: 4
(University of Lübeck)
+ 27 AuthorsAndreas Ziegler77
Estimated H-index: 77
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain carrying the mitochondrial genome of an AKR/J mouse str...
Source Cite
Published on Jan 19, 2018in Nature Reviews Endocrinology 20.27
Maximilian Kleinert16
Estimated H-index: 16
,
Christoffer Clemmensen21
Estimated H-index: 21
(Technische Universität München)
+ 17 AuthorsAnnette Schürmann43
Estimated H-index: 43
Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschop and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.
36 Citations Source Cite
Published on Apr 1, 2018in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Steffen Priebe16
Estimated H-index: 16
(Leibniz Association)
+ 7 AuthorsMichael Ristow47
Estimated H-index: 47
(École Polytechnique Fédérale de Lausanne)
Summary Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. M...
5 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Peer Aramillo Irizar1
Estimated H-index: 1
(University of Kiel),
Sascha Schäuble10
Estimated H-index: 10
(University of Jena)
+ 25 AuthorsUwe Menzel6
Estimated H-index: 6
(Leibniz Association)
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories ...
6 Citations Source Cite
Published on Nov 16, 2018in bioRxiv
Misa Hirose15
Estimated H-index: 15
,
Paul Schilf4
Estimated H-index: 4
+ 12 AuthorsJan Rupp28
Estimated H-index: 28
Mitochondrial complex I, the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery, has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA-encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants i...
Source Cite
Published on Jul 1, 2017in Free Radical Biology and Medicine 6.02
Leonid Rozanov (ETH Zurich), Johannes Mansfeld6
Estimated H-index: 6
(ETH Zurich)
+ 1 AuthorsMichael Ristow47
Estimated H-index: 47
(ETH Zurich)
Life expectancy in industrialized countries has significantly increased in recent years. The aim to extend healthy lifespan, a.k.a healthspan, requires the identification and characterization of molecular pathways mechanistically linked to the aging process. To identify conserved transcriptional patterns involved in decline of organisms associated with aging we analyzed deep sequencing data from 3 species (the nematode C. elegans , the zebrafish D. rerio , and M. musculus ) at three time-points ...
Source Cite
Published on Oct 1, 2017in Genetics 4.08
Jennifer L. Watts27
Estimated H-index: 27
(Washington State University),
Michael Ristow47
Estimated H-index: 47
(ETH Zurich)
Abstract Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior. In this review, we outline lipid and carbohydrate structures as...
7 Citations Source Cite
Published on Oct 1, 2017in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Gerald Grandl4
Estimated H-index: 4
,
Michael Ristow47
Estimated H-index: 47
(École Polytechnique Fédérale de Lausanne)
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
1 Citations Source Cite
Published on Apr 1, 2017in Redox biology 7.13
Nadine Urban3
Estimated H-index: 3
(University of Jena),
Dimitrios Tsitsipatis2
Estimated H-index: 2
(University of Jena)
+ 6 AuthorsLars-Oliver Klotz18
Estimated H-index: 18
(University of Jena)
Abstract The redox environment in cells and organisms is set by low-molecular mass and protein-bound thiols, with glutathione (GSH) representing a major intracellular redox buffer. Subtle thiol oxidation elicits signal transduction processes and adaptive responses to cope with stressors, whereas highly oxidizing conditions may provoke cell death. We here tested how thiol depletion affects life span, stress resistance and stress signaling in the model organism Caenorhabditis elegans . Diethyl mal...
16 Citations Source Cite
Published on Aug 1, 2017in Aging Cell 7.63
Troy L. Merry13
Estimated H-index: 13
(École Polytechnique Fédérale de Lausanne),
Doreen Kuhlow9
Estimated H-index: 9
(Schiller International University)
+ 5 AuthorsKim Zarse17
Estimated H-index: 17
(École Polytechnique Fédérale de Lausanne)
Summary Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/−) or homozygous (PerIRKO−/−) disruption of the IR in peripheral tissue of 15-weeks-old mice using a tamoxifen-inducible Cre transgenic mouse with only peripheral tissue expression, and subsequentl...
2 Citations Source Cite
12345678910