Winfried Graninger
Medical University of Graz
Physical therapyImmunologyRheumatoid arthritisDiabetes mellitusMedicine
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Publications 185
#1Barbara Dreo (Medical University of Graz)
#2Barbara Prietl (Medical University of Graz)H-Index: 11
Last. Hans Peter Brezinschek (Medical University of Graz)H-Index: 3
view all 10 authors...
Background: Under physiological conditions, T regulatory cells (Tregs) are responsible for the downregulation of the immune response. In autoimmune diseases, such as rheumatoid arthritis (RA), auto-inflammation is driven by an imbalance of activation and downregulation of immunological pathways. Thus, treatment plans for autoimmune diseases often involve the enhancement of immunoregulatory pathways by administering inhibitors of costimulation, i.e. CTLA-4-Ig (abatacept, ABA). ABA binds specifica...
#1Philipp Bosch (Medical University of Graz)
#2Rusmir Husic (Medical University of Graz)H-Index: 7
Last. Christian Dejaco (Medical University of Graz)H-Index: 29
view all 9 authors...
Background: Tender and Swollen Joint Counts (TJC, SJC) are items of disease activity scores in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Recent studies suggest that TJC do not adequately reflect ongoing inflammation in RA when using Ultrasound (US) as a reference standard, and that pain might be due to other, non-inflammatory causes.1, 2 In PsA, the role of tenderness and swelling of joints for reflecting active inflammation has not been well studied so far. Objectives: To evaluat...
#1Johannes Fessler (Medical University of Graz)H-Index: 1
#2Patrizia Fasching (Medical University of Graz)H-Index: 2
Last. Wolfgang Schwinger (Medical University of Graz)H-Index: 15
view all 11 authors...
OBJECTIVE: To investigate peripheral lymphopenia, a frequent finding in primary Sjogren's syndrome (pSS) associated with higher disease activity and increased mortality. METHODS: Prospective, cross-sectional study of consecutive patients with pSS (n = 66) and healthy controls (n = 181). Lymphocyte subsets were analysed by flow cytometry, naive (CD45RA+) and memory (CD45RO+) CD4+ T cells were purified by MACS technology. In vitro proliferation and senescence-associated beta-galactosidase (SABG) w...
#1Martin AringerH-Index: 51
#2Ralph BrinksH-Index: 17
Last. Josef S. SmolenH-Index: 115
view all 52 authors...
#1Angelika Lackner (University of Graz)H-Index: 5
#2Daniel HeberH-Index: 2
Last. Winfried Graninger (University of Graz)H-Index: 40
view all 11 authors...
OBJECTIVES: The aim of this prospective study was to examine whether ultrasound or clinical abnormalities at enthesal sites predict radiographic progression at entheses in psoriatic arthritis (PsA). METHODS: Consecutive PsA patients were included and subjected to clinical and ultrasound assessments at 14 entheses at baseline, 6 and 12 months. Radiographs were performed at 0 and 12 months. By US, we investigated structural (erosions, osteophytes) and inflammatory changes [grey scale (0-32) and po...
#2Karin Böckl (University of Graz)
Last. Astrid Ortner (University of Graz)H-Index: 7
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Background Treating patients with inflammatory joint diseases (rheumatoid arthritis, psoriatic arthritis) according to established treatment algorithms often requires the simultaneous use of three or more medications to relieve symptoms and prevent long-term joint damage as well as disability.
#1Philipp Bosch (University of Graz)
#2Rusmir Husic (University of Graz)H-Index: 7
Last. Christian Dejaco (University of Graz)H-Index: 29
view all 9 authors...
OBJECTIVE: To evaluate low disease activity (LDA) cut-offs in psoriatic arthritis (PsA) using ultrasound. METHODS: Eighty-three PsA patients underwent clinical and ultrasound examinations at two visits. LDA was assessed using the Disease Activity index for Psoriatic Arthritis (DAPSA ⩽ 14), the Psoriatic ArthritiS Disease Activity Score (PASDAS ⩽ 3.2), the Composite Psoriatic Disease Activity Index ⩽ 4, the DAS28-CRP ⩽ 2.8 and the minimal disease activity criteria. Ultrasound was performed at 68 ...
#1Martin Aringer (TUD: Dresden University of Technology)H-Index: 51
#2Karen H. Costenbader (Brigham and Women's Hospital)H-Index: 51
Last. Sindhu R JohnsonH-Index: 13
view all 64 authors...
Objective To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). Methods This international initiative had four phases. (1) Evaluation of antinuclear antibody (ANA) as an entry criterion through systematic review and meta-regression of the literature and criteria generation through an international Delphi exercise, an early patient cohort and a patient survey...
60 CitationsSource
#1Barbara Dreo (Medical University of Graz)
#2Rusmir Husic (Medical University of Graz)H-Index: 7
Last. Martin H. Stradner (Medical University of Graz)H-Index: 12
view all 8 authors...
Background: In rheumatoid arthritis (RA) stratification is considered an important step towards the development of patient-tailored therapeutic concepts. The fact that less than 50% of RA patients experience a substantial improvement in response to any single biologic therapy has brought up the idea that yet unidentified subtypes of RA (endotypes) might exist. This concept is in line with distinct microscopic patterns of synovitis found in biopsies of RA joints.[1] Furthermore, a subset of RA pa...
Background: Rituximab (RTX) is a monoclonal antibody that targets the CD20 surface marker. This results in a reduction of CD20+ immune cell populations, foremost B cells. B cell depletion via RTX was found to be beneficial for patients suffering from systemic sclerosis (SSc), leading to an improvement of skin fibrosis and autoimmunity (1,2). However, little is known about the influence of RTX on specific B subsets in SSc. Objectives: The purpose of this study was to further characterize the effe...