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Ikuo Tomioka
Shinshu University
Induced pluripotent stem cellEmbryonic stem cellMolecular biologyMarmosetBiology
24Publications
11H-index
791Citations
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Publications 24
Newest
#1Toshiaki Watanabe (Central Institute for Experimental Animals)H-Index: 1
#2Shun Yamazaki (Central Institute for Experimental Animals)H-Index: 1
Last. Erika Sasaki (Central Institute for Experimental Animals)H-Index: 21
view all 11 authors...
1 CitationsSource
#1Kentaro Takae (Shinshu University)H-Index: 2
#2Mizuho Nakata (Shinshu University)H-Index: 1
Last. Ikuo Tomioka (Shinshu University)H-Index: 11
view all 6 authors...
2 CitationsSource
#1Ikuo TomiokaH-Index: 11
#2Yoshitaka NagaiH-Index: 30
Last. Kazuhiko SekiH-Index: 15
view all 3 authors...
Source
#1Ikuo Tomioka (Shinshu University)H-Index: 11
#2Naotake NogamiH-Index: 2
Last. Kazuhiko SekiH-Index: 15
view all 10 authors...
Controllable transgene expression systems are indispensable tools for the production of animal models of disease to investigate protein functions at defined periods. However, in nonhuman primates that share genetic, physiological, and morphological similarities with humans, genetic modification techniques have not been well established; therefore, the establishment of novel transgenic models with controllable transgene expression systems will be valuable tools to understand pathological mechanis...
8 CitationsSource
#1Yoshitaka NagaiH-Index: 30
#2Ikuo TomiokaH-Index: 11
Last. Kazuhiko SekiH-Index: 15
view all 20 authors...
Source
#1Ikuo TomiokaH-Index: 11
Last. Kazuhiko SekiH-Index: 15
view all 27 authors...
Abstract Age-associated neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan. Although various rodent models have been developed to study and overcome these diseases, they have limitations in their translational research utility owing to differences from humans in brain structure and function and in drug metabolism. Here, we generated a transgenic marmoset ...
24 CitationsSource
#1Hiroko Shimada (Keio: Keio University)H-Index: 3
#2Yohei Okada (Keio: Keio University)H-Index: 30
Last. Hideyuki Okano (Keio: Keio University)H-Index: 112
view all 13 authors...
The common marmoset (Callithrix jacchus) is a small New World primate that has been used as a non-human primate model for various biomedical studies. We previously demonstrated that transplantation of neural stem/progenitor cells (NS/PCs) derived from mouse and human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) promote functional locomotor recovery of mouse spinal cord injury models. However, for the clinical application of such a therapeutic approach, we need to evalua...
21 CitationsSource
#1Ikuo Tomioka (Central Institute for Experimental Animals)H-Index: 11
#2Tsukasa Takahashi (Central Institute for Experimental Animals)H-Index: 1
Last. Erika Sasaki (Central Institute for Experimental Animals)H-Index: 21
view all 5 authors...
Abstract Optimization of oocyte culture conditions is a crucial aspect of reproductive biology and technology. In the present study, maturation of germinal vesicle-stage marmoset oocytes were evaluated in the following media: Waymouth medium, Waymouth medium containing porcine follicular fluid (pFF) (Waymouth-pFF medium), and porcine oocyte medium (POM). Oocytes cultured in Waymouth-pFF medium had higher maturation rates to the metaphase II stage than those cultured in Waymouth medium (36.1% vs....
17 CitationsSource
#1Masanori Imamura (Keio: Keio University)H-Index: 7
#2Hironobu Okuno (Keio: Keio University)H-Index: 6
Last. Hideyuki Okano (Keio: Keio University)H-Index: 112
view all 11 authors...
5 CitationsSource
#1Ikuo Tomioka (Central Institute for Experimental Animals)H-Index: 11
#2Erika Sasaki (Central Institute for Experimental Animals)H-Index: 21
The four transcription factors Oct-3/4, Sox2, Klf4, and c-Myc induce pluripotency in somatic cells. These embryonic stem (ES) cell-like induced pluripotent stem (iPS) cells have potential for therapeutic applications in humans, and iPS cell technology has shown dramatic advances in recent years. The common marmoset (Callithrix jacchus) offers many advantages over other laboratory primates for medical studies, including reproductive biology studies. In this chapter, we introduce a generation of m...
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