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Etienne Frumence
University of La Réunion
9Publications
3H-index
123Citations
Publications 10
Newest
Emerging infections of mosquito-borne Zika virus (ZIKV) pose an increasing threat to human health, as documented over the recent years in South Pacific islands and the Americas in recent years. To better understand molecular mechanisms underlying the increase in human cases with severe pathologies, we recently demonstrated the functional roles of structural proteins capsid (C), pre-membrane (prM), and envelop (E) of ZIKV epidemic strains with the initiation of viral infection in human cells. Spe...
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#1Jonathan TurpinH-Index: 2
#2Etienne FrumenceH-Index: 3
Last.Pascale Krejbich-TrototH-Index: 10
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Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction of cell death. However, previous studies suggest that the virally induced apoptosis occurs at a slower rate compared to the course of viral production. In this present study, we investigated the capacity of ZIKV to delay host cell apoptosis. We provide evidence...
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#1Jonathan TurpinH-Index: 2
#2Etienne FrumenceH-Index: 3
Last.Wildriss ViranaickenH-Index: 8
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#1Etienne FrumenceH-Index: 3
Last.Philippe DesprèsH-Index: 50
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Zika virus (ZIKV) is an emerging arthropod-borne virus of major public health concern. ZIKV infection is responsible for congenital Zika disease and other neurological defects. Antibody-mediated virus neutralization is an essential component of protective antiviral immunity against ZIKV. In the present study, we assessed whether our GFP reporter ZIKV derived from African viral strain MR766 could be useful for the development of a flow cytometry neutralization test (FNT), as an alternative to the...
1 CitationsSource
#1Etienne FrumenceH-Index: 3
Last.Philippe DesprèsH-Index: 50
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Zika virus (ZIKV) is an emerging mosquito-borne flavivirus which is of major public health concern. ZIKV infection is recognized as the cause of congenital Zika disease and other neurological defects, with no specific prophylactic or therapeutic treatments. As the humoral immune response is an essential component of protective immunity, there is an urgent need for effective vaccines that confer protection against ZIKV infection. In the present study, we evaluate the immunogenicity of chimeric vi...
1 CitationsSource
#2Etienne FrumenceH-Index: 3
Last.Wildriss ViranaickenH-Index: 8
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Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA repl...
5 CitationsSource
#1Etienne Frumence (University of La Réunion)H-Index: 3
#2Marjolaine Roche (University of La Réunion)H-Index: 6
Last.Pascale Guiraud (University of La Réunion)H-Index: 27
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Abstract Arthritogenic alphaviruses are emerging arthropod-borne viruses that occasionally cause sporadic to global outbreaks all over the world. Many environmental factors including xenobiotics have been identified as capable of influencing the spread, the susceptibility and the outcome of viral infection. Among them cadmium is a toxic non-essential heavy metal and a prevalent environmental contaminant. In the present study we evaluated the effect of cadmium exposure on alphavirus infection in ...
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#1Etienne Frumence (University of La Réunion)H-Index: 3
#2Marjolaine Roche (University of La Réunion)H-Index: 6
Last.Philippe Desprès (University of La Réunion)H-Index: 50
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Zika virus (ZIKV) is an emerging flavivirus since the first epidemics in South Pacific in 2007. The recent finding that ZIKV is now circulating in Western Hemisphere and can be associated to severe human diseases, warrants the need for its study. Here we evaluate the susceptibility of human lung epithelial A549 cells to South Pacific epidemic strain of ZIKV isolated in 2013. We showed that ZIKV growth in A549 cells is greatly efficient. ZIKV infection resulted in the secretion of IFN-β followed ...
70 CitationsSource
#1Malini Manoharan (University of La Réunion)H-Index: 4
#2Matthieu Ng Fuk Chong (University of La Réunion)H-Index: 2
Last.Bernard Offmann (University of La Réunion)H-Index: 19
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About 1 million people in the world die each year from diseases spread by mosquitoes, and understanding the mechanism of host identification by the mosquitoes through olfaction is at stake. The role of odorant binding proteins (OBPs) in the primary molecular events of olfaction in mosquitoes is becoming an important focus of biological research in this area. Here, we present a comprehensive comparative genomics study of OBPs in the three disease-transmitting mosquito species Anopheles gambiae, A...
46 CitationsSource
#1Bernard OffmannH-Index: 19
#2Manoj TyagiH-Index: 15
Last.Alexandre G. de BrevernH-Index: 23
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