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Georg Schett
University of Erlangen-Nuremberg
Physical therapyImmunologyArthritisRheumatoid arthritisMedicine
1,037Publications
91H-index
34.8kCitations
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Publications 1055
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#1Georg Schett (FAU: University of Erlangen-Nuremberg)H-Index: 91
#2Michael Sticherling (FAU: University of Erlangen-Nuremberg)H-Index: 36
Last. Markus F. Neurath (FAU: University of Erlangen-Nuremberg)H-Index: 99
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COVID-19, caused by the SARS-CoV-2 virus, has become pandemic. With sharply rising infection rates, patient groups characterized by an enhanced infection risk will be challenged by the virus. In this context, patients with chronic immune-mediated inflammatory diseases are of particular interest, as these diseases are characterized by an intrinsic immune dysfunction leading to inflammation that may enhance risk for severe infection. Immune-mediated inflammatory diseases are often treated with cyt...
1 CitationsSource
#1Narges Tajik (FAU: University of Erlangen-Nuremberg)
#2Michael Frech (FAU: University of Erlangen-Nuremberg)H-Index: 1
Last. Andreas Rings (University of Hohenheim)H-Index: 5
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Gut microbial dysbiosis is associated with the development of autoimmune disease, but the mechanisms by which microbial dysbiosis affects the transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating autoimmunity to inflammation. Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice and humans and ca...
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#1Vugar Azizov (FAU: University of Erlangen-Nuremberg)
#2Katharina Dietel (FAU: University of Erlangen-Nuremberg)H-Index: 6
Last. Lisa Knipfer (FAU: University of Erlangen-Nuremberg)H-Index: 1
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Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (TFH) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties. Alcohol-exposed mice have reduced Bcl6 and PD-1 expression as well a...
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#1Andreas Friedberger (FAU: University of Erlangen-Nuremberg)H-Index: 4
#2Camille P. Figueiredo (FAU: University of Erlangen-Nuremberg)H-Index: 13
Last. Georg Schett (FAU: University of Erlangen-Nuremberg)H-Index: 91
view all 11 authors...
BACKGROUND: Psoriasis (Pso), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are inflammatory diseases. PsA and RA are characterized by bone and muscle loss. In RA, bone loss has been extensively characterized, but muscle loss has, to the best of our knowledge, not been quantified to date. METHODS: A random forest based segmentation method was used to analyze hand muscle volume in T1 weighted MRI images of 330 patients suffering from Pso, PsA or RA. In addition, fat volume was quantified...
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#1Johannes Knitza (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2A. Kleyer (FAU: University of Erlangen-Nuremberg)H-Index: 4
Last. David Simon (FAU: University of Erlangen-Nuremberg)H-Index: 7
view all 7 authors...
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#1Nick Barkham (New Cross Hospital)H-Index: 3
#2Georg Schett (FAU: University of Erlangen-Nuremberg)H-Index: 91
Last. Shephard Mpofu (Novartis)H-Index: 15
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#1Yasunori Omata (UTokyo: University of Tokyo)H-Index: 7
#2Michael Frech (FAU: University of Erlangen-Nuremberg)H-Index: 1
Last. Kerstin Sarter (FAU: University of Erlangen-Nuremberg)H-Index: 12
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Abstract While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently inhibit the generation of bone resorbing osteoclasts in vitro as well as favorably influence bone homeostasis under steady state conditions in vivo using loss and gain of ...
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#1Yanli Tong (Sichuan University)
#2Tony N. Marion (Sichuan University)H-Index: 1
Last. Yi Liu (Sichuan University)H-Index: 8
view all 5 authors...
Abstract As a gigantic community in the human body, the microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients from food, defense against infection of pathogens, to regulation of immune system development and immune homeostasis. Recent advances in “omics” studies and bioinformatics analyses have broadened our insights of the microbiota composition of the inner and other surfaces of the body and their interactions with the host. Apart fr...
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#1Patrick Süß (University of Freiburg)H-Index: 3
#2Alana Hoffmann (FAU: University of Erlangen-Nuremberg)H-Index: 5
Last. Christopher K. Glass (UCSD: University of California, San Diego)H-Index: 139
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Summary Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced by chronic peripheral inflammation. This shift in the myeloid compartment is associated with the appearance of an inflammatory myeloid subpopulation in the cortex, striatum, ...
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