Matthew Meyerson
Harvard University
CancerMolecular biologyCancer researchGeneticsBiology
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Publications 650
#1Giuseppe Lamberti (Harvard University)H-Index: 3
#1G. Lamberti (Harvard University)H-Index: 1
Last. Andrew D. Cherniack (Harvard University)H-Index: 57
view all 11 authors...
INTRODUCTION: Programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) is the primary clinically-available biomarker of response to immunotherapy in non-small cell lung cancer (NSCLC), but factors associated with PD-L1 expression are not well understood. METHODS: Consecutive nonsquamous NSCLCs with successful PD-L1 assessment and targeted next-generation sequencing (NGS) were included in this retrospective study. Clinicopathological characteristics, gene mutations, and copy number cha...
#1Alison Marie Taylor (CUMC: Columbia University Medical Center)
#2Sejal V. Jain (Harvard University)H-Index: 1
Last. Matthew Meyerson (Harvard University)H-Index: 160
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Aneuploidy, whole-chromosome or chromosome arm copy number imbalance, is a near-universal characteristic of human cancers. We previously applied methods that define chromosome arm-level aneuploidy and a global cancer aneuploidy score to 10,522 tumors of 33 types in The Cancer Genome Atlas (TCGA). Aneuploidy level was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Overall aneuploidy was anti-correlated with expression of immune signaling genes, due to...
#1Jian Carrot-Zhang (Broad Institute)H-Index: 1
#2Nyasha ChambweH-Index: 23
Last. Justin Y. Newberg (Foundation Medicine)H-Index: 1
view all 43 authors...
Summary We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confounders that have been insufficiently accounted for. Once accounted for, ancestry-associated differences spanned all molecular features and hundreds of genes. Biologically significant differences were usually tissue specific ...
2 CitationsSource
#1Jason Nomburg (Harvard University)H-Index: 2
#2Matthew Meyerson (Harvard University)H-Index: 160
Last. James A. DeCaprio (Harvard University)H-Index: 67
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SARS-CoV-2, a positive-sense RNA virus in the family Coronaviridae, has caused the current worldwide pandemic, known as coronavirus disease 2019 or COVID-19. The definition of SARS-CoV-2 open reading frames is a key step in delineating targets for vaccination and treatment for COVID-19. Here, we report an integrative analysis of three independent direct RNA sequencing datasets of the SARS-CoV-2 transcriptome. We find strong evidence for variant open reading frames (ORFs) encoded by SARS-CoV-2 RN...
1 CitationsSource
#1Orit Rozenblatt-Rosen (Broad Institute)H-Index: 19
#2Aviv Regev (MIT: Massachusetts Institute of Technology)H-Index: 110
Last. Emek Demir (OHSU: Oregon Health & Science University)H-Index: 4
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Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinic...
3 CitationsSource
#1Jason Nomburg (Harvard University)H-Index: 2
#2Susan Bullman (Fred Hutchinson Cancer Research Center)
Last. James A. DeCaprio (Harvard University)H-Index: 67
view all 13 authors...
Background: Esophageal cancer is a leading cause of cancer-associated deaths worldwide. Notably, there is a disproportionately high incidence of esophageal squamous cell carcinoma (ESCC) throughout the eastern corridor of Africa. One possible explanation for the unique geographic distribution of ESCC may be the human microbiome, which has been shown to influence other gastrointestinal (GI) cancers, including gastric and colorectal cancer (CRC). Methods: To address this question, we conducted RNA...
#1Zhouwei Zhang (Broad Institute)H-Index: 1
#2Netta Mäkinen (Broad Institute)H-Index: 1
Last. Matthew Meyerson (Broad Institute)H-Index: 160
view all 7 authors...
Ileal neuroendocrine tumors (NETs) represent the most common neoplasm of the small intestine. Although up to 50% of patients with ileal NETs are diagnosed with multifocal disease, the mechanisms by which multifocal ileal NETs arise are not yet understood. In this study, we analyzed genome-wide sequencing data to examine patterns of copy number variation in 40 synchronous primary ileal NETs derived from three patients. Chromosome (chr) 18 loss of heterozygosity (LOH) was the most frequent copy nu...
1 CitationsSource
#2Y. Mitsuishi (Broad Institute)
Last. Xiaoyang Zhang (HCI: Huntsman Cancer Institute)H-Index: 14
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Genomic analysis of lung adenocarcinomas has revealed that the MGA gene, which encodes a heterodimeric partner of the MYC-interacting protein MAX, is significantly mutated or deleted in lung adenocarcinomas. Most of the mutations are loss-of-function for MGA, suggesting that MGA may act as a tumor suppressor. Here, we characterize both the molecular and cellular role of MGA in lung adenocarcinomas and illustrate its functional relevance in the MYC pathway. Although MGA and MYC interact with the ...
#1Jason NomburgH-Index: 2
#2Susan BullmanH-Index: 16
Last. Matthew MeyersonH-Index: 160
view all 11 authors...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematologic malignancy believed to originate from plasmacytoid dendritic cells (pDCs), the immune cells responsible for producing type 1 interferons during infection. Nearly all patients with BPDCN have prominent skin involvement, with cutaneous infiltration occupying the dermis and subcutis. One half of patients present with BPDCN cells only in the skin, with no evidence of disease elsewhere. Because normal pDCs are rare or absent in cut...
#1Xiaoyun WuH-Index: 9
#2Gavin R. Schnitzler (Broad Institute)
Last. Timothy A. LewisH-Index: 9
view all 19 authors...
Cytotoxic molecules can kill cancer cells by disrupting critical cellular processes or by inducing novel activities. 6-(4-(Diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (DNMDP) is a small molecule that kills cancer cells by generation of novel activity. DNMDP induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) and specifically kills cancer cells expressing elevated levels of these two proteins. Here, we examined the charact...