Na Sun
Publications 21
#1Na SunH-Index: 8
#2Thomas KunzkeH-Index: 2
Last.Nicolas Schlegel (University of Würzburg)H-Index: 17
view all 17 authors...
Background: Adrenocortical carcinoma (ACC) is a rare tumor with variable prognosis even within the same tumor stage. Cancer-related sex hormones and their sulfated metabolites in body fluids can be used as tumor markers. The role of steroid sulfation in ACC has not yet been studied. MALDI mass spectrometry imaging (MALDI-MSI) is a novel tool for tissue-based chemical phenotyping. Methods: We performed phenotyping of formalin-fixed, paraffin-embedded tissue samples from 72 ACC by MALDI-MSI at a m...
#1Thomas G. Papathomas (University of Birmingham)
#2Na SunH-Index: 8
Last.Axel WalchH-Index: 52
view all 10 authors...
Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and endocrine-related disease has significantly expanded over the last decade. Herein, we focus on novel metabolomics-related methodologies in adrenal research: in situ metabolomics by mass spectrometry imaging, steroid metabolomics by gas and liquid chromatography–m...
#1Na SunH-Index: 8
#2Isis E. Fernandez (LMU: Ludwig Maximilian University of Munich)H-Index: 14
Last.Oliver Eickelberg (LMU: Ludwig Maximilian University of Munich)H-Index: 48
view all 11 authors...
Idiopathic pulmonary fibrosis (IPF) is a fatal condition that reduces life expectancy and shows a limited response to available therapies. Pirfenidone has been approved for treatment of IPF, but little is known about the distinct metabolic changes that occur in the lung upon pirfenidone administration. Here, we performed a proof-of-concept study using high-resolution quantitative matrix-assisted laser desorption/ionisation Fourier-transform ion cyclotron resonance mass spectrometry imaging (MALD...
#1Na SunH-Index: 8
#2Yin WuH-Index: 2
Last.William E. Rainey (UM: University of Michigan)H-Index: 22
view all 13 authors...
In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone producing adrenal cortex and the catecholamine producing medulla is ill defined at the level of small molecules. Here, we report the first comprehensive high-resolution mass spectrometry imaging (MSI) map of the normal human adrenal gland...
#1Michaela AichlerH-Index: 26
#2Thomas KunzkeH-Index: 2
Last.Axel WalchH-Index: 52
view all 8 authors...
Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine
#1Michaela AichlerH-Index: 26
#2Daniela BorgmannH-Index: 6
Last.Martin JastrochH-Index: 27
view all 19 authors...
Summary The processes contributing to β cell dysfunction in type 2 diabetes (T2D) are uncertain, largely because it is difficult to access β cells in their intact immediate environment. We examined the pathophysiology of β cells under T2D progression directly in pancreatic tissues. We used MALDI imaging of Langerhans islets (LHIs) within mouse tissues or from human tissues to generate in situ-omics data, which we supported with in vitro experiments. Molecular interaction networks provided inform...
#1Alice LyH-Index: 6
#2Achim BuckH-Index: 10
Last.Gregor WeirichH-Index: 35
view all 17 authors...
Formalin-fixed paraffin embedding (FFPE) of tissues has been assumed to alter the metabolite content or chemical state, hampering metabolomics studies. Here, Ly et al. describe reproducible metabolomic analysis of FFPE samples by mass spectrometry imaging.