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Na Sun
MALDI imagingMetabolomicsMass spectrometry imagingMetaboliteBiology
21Publications
8H-index
288Citations
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Publications 25
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The adrenal gland integrates catecholamine-producing neuroendocrine cells and steroid-producing cells with mesenchymal origin in a structured manner under one capsule and is a key regulator for vital bioactivity. In addition to adrenal-specific disease, dysregulation of adrenal hormones is associated with systemic effects, leading to undesirable metabolic and cardiovascular consequences. Mass spectrometry imaging (MSI) technique can simultaneously measure a broad range of biomolecules, including...
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#1Isabel Weigand (University of Würzburg)H-Index: 7
#2Jochen Schreiner (University of Würzburg)
Last. José Pedro Friedmann Angeli (University of Würzburg)H-Index: 5
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Conditions of impaired adrenal function and tissue destruction, such as in Addison’s disease, and treatment resistance of adrenocortical carcinoma (ACC) necessitate improved understanding of the pathophysiology of adrenal cell death. Due to relevant oxidative processes in the adrenal cortex, our study investigated the role of ferroptosis, an iron-dependent cell death mechanism and found high adrenocortical expression of glutathione peroxidase 4 (GPX4) and long-chain-fatty-acid CoA ligase 4 (ACSL...
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#1Na SunH-Index: 8
#2Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 30
view all 8 authors...
Aldosterone-producing adenomas (APAs) are one of the main causes of primary aldosteronism and the most prevalent surgically correctable form of hypertension. Aldosterone-producing cell clusters (AP...
3 CitationsSource
#1Na SunH-Index: 8
#2Thomas KunzkeH-Index: 2
Last. Matthias Kroiss (University of Würzburg)H-Index: 22
view all 17 authors...
Background: Adrenocortical carcinoma (ACC) is a rare tumor with variable prognosis even within the same tumor stage. Cancer-related sex hormones and their sulfated metabolites in body fluids can be used as tumor markers. The role of steroid sulfation in ACC has not yet been studied. MALDI mass spectrometry imaging (MALDI-MSI) is a novel tool for tissue-based chemical phenotyping. Methods: We performed phenotyping of formalin-fixed, paraffin-embedded tissue samples from 72 ACC by MALDI-MSI at a m...
1 CitationsSource
#2Yara RhayemH-Index: 4
Last. Felix BeuschleinH-Index: 57
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Recent genetic examinations and multisteroid profiles have provided the basis for subclassification of aldosterone-producing adenomas (APAs). The objective of the current study was to produce a comprehensive, high-resolution mass spectrometry imaging (MSI) map of APAs in relation to morphometry, immunohistochemical profiles, mutational status, and clinical outcome. The study cohort comprised 136 patients with unilateral primary aldosteronism. Matrix-assisted laser desorption/ionization-Fourier t...
1 CitationsSource
#1Thomas G. Papathomas (University of Birmingham)
#2Na SunH-Index: 8
Last. Axel WalchH-Index: 56
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Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and endocrine-related disease has significantly expanded over the last decade. Herein, we focus on novel metabolomics-related methodologies in adrenal research: in situ metabolomics by mass spectrometry imaging, steroid metabolomics by gas and liquid chromatography–m...
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#1Isis E. FernandezH-Index: 14
#2Na SunH-Index: 8
Last. Oliver EickelbergH-Index: 57
view all 9 authors...
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#1Na SunH-Index: 8
#2Isis E. Fernandez (LMU: Ludwig Maximilian University of Munich)H-Index: 14
Last. Axel WalchH-Index: 56
view all 11 authors...
Idiopathic pulmonary fibrosis (IPF) is a fatal condition that reduces life expectancy and shows a limited response to available therapies. Pirfenidone has been approved for treatment of IPF, but little is known about the distinct metabolic changes that occur in the lung upon pirfenidone administration. Here, we performed a proof-of-concept study using high-resolution quantitative matrix-assisted laser desorption/ionisation Fourier-transform ion cyclotron resonance mass spectrometry imaging (MALD...
1 CitationsSource
#1Na SunH-Index: 8
#2Yin WuH-Index: 2
Last. Matthias Kroiss (University of Würzburg)H-Index: 22
view all 13 authors...
In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone producing adrenal cortex and the catecholamine producing medulla is ill defined at the level of small molecules. Here, we report the first comprehensive high-resolution mass spectrometry imaging (MSI) map of the normal human adrenal gland...
6 CitationsSource
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