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Susanne Gräslund
Structural Genomics Consortium
Crystal structureChemistryBiochemistryStereochemistryCrystallography
234Publications
21H-index
1,819Citations
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Publications 234
Newest
#1Michael Fairhead (University of Oxford)H-Index: 8
#1Michael Fairhead (SGC: Structural Genomics Consortium)H-Index: 17
Last. Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
view all 11 authors...
Antibody fragments have great potential as crystallization chaperones for structural biology due to their ability to either stabilise targets, trap certain conformations and/or promote crystal packing. Here we present an example of using a single-chain variable fragment (scFv) to determine the previously unsolved structure of the multidomain protein SP140. This nuclear leukocyte-specific protein contains domains related to chromatin-mediated gene expression and has been implicated in various dis...
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#1Cátia Fernandes-Cerqueira (KI: Karolinska Institutet)H-Index: 4
#2Nuria Renard (KI: Karolinska Institutet)H-Index: 1
Last. Susanna L. Lundström (KI: Karolinska Institutet)H-Index: 13
view all 8 authors...
IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in patients with idiopathic inflammatory myopathies (IIM) and anti-synthetase syndrome (ASS) with associated interstitial lung disease (ILD). Thus, we hypothesized that the total-IgG Fc-glycans from Jo1+ versus Jo1− patients and anti-Jo1-IgG would show characteristic differences, and that particular Fc-glycan features would be associat...
1 CitationsSource
#1Nicholas Favalli (ETH Zurich)H-Index: 4
#2Stefan Biendl (ETH Zurich)H-Index: 2
Last. Dario Neri (ETH Zurich)H-Index: 73
view all 12 authors...
: A DNA-encoded chemical library (DECL) with 1.2 million compounds was synthesized by combinatorial reaction of seven central scaffolds with two sets of 343×492 building blocks. Library screening by affinity capture revealed that for some target proteins, the chemical nature of building blocks dominated the selection results, whereas for other proteins, the central scaffold also crucially contributed to ligand affinity. Molecules based on a 3,5-bis(aminomethyl)benzoic acid core structure were fo...
5 CitationsSource
#1Nicholas Favalli (ETH Zurich)H-Index: 4
#2Stefan Biendl (ETH Zurich)H-Index: 2
Last. Dario Neri (ETH Zurich)H-Index: 73
view all 12 authors...
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#1Michael FairheadH-Index: 17
#2Susanne GräslundH-Index: 21
Last. F. von DelftH-Index: 14
view all 16 authors...
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#1Capucine Van Rechem (Harvard University)H-Index: 15
#2Joshua C. Black (Harvard University)H-Index: 17
Last. Johnathan R. Whetstine (Harvard University)H-Index: 29
view all 14 authors...
Single nucleotide polymorphisms (SNPs) occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence impact cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contribution, their use in sub-classifying patients and their impact on therapeutic response. We demonstrate that coding SNP-A482 within the lysine tri-demethylase KDM4A/JMJD2A associates with differential outcome in cancer pa...
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#1Helena Persson (KTH: Royal Institute of Technology)H-Index: 3
#2Charlotta Preger (KI: Karolinska Institutet)H-Index: 1
Last. Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
view all 5 authors...
We describe a mass spectrometry-based approach for validation of antibody specificity. This method allows validation of antibodies or antibody fragments, against their endogenous targets. It can as ...
3 CitationsSource
#1Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
#2Pavel Savitsky (University of Oxford)H-Index: 4
Last. Susanne Müller-Knapp (University of Oxford)H-Index: 3
view all 3 authors...
: Site-specific biotinylation of proteins is often the method of choice to enable efficient immobilization of a protein on a surface without interfering with protein folding. The tight interaction of biotin and streptavidin is frequently used to immobilize an antigen during phage display selections of binders. Here we describe a method of in vivo biotinylation of proteins during expression in E. coli, by tagging the protein with the short biotin acceptor peptide sequence, Avi tag, and co-express...
4 CitationsSource
#1M. El BakkouriH-Index: 1
#2John R. WalkerH-Index: 51
Last. D.V. LovatoH-Index: 1
view all 9 authors...
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#1M. El BakkouriH-Index: 1
#2John R. WalkerH-Index: 51
Last. D.V. LovatoH-Index: 1
view all 9 authors...
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