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Susanne Gräslund
Karolinska Institutet
233Publications
21H-index
1,683Citations
Publications 233
Newest
#1Michael Fairhead (University of Oxford)H-Index: 7
#2Charlotta Preger (KI: Karolinska Institutet)H-Index: 1
Last.Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
view all 11 authors...
Antibody fragments have great potential as crystallization chaperones for structural biology due to their ability to either stabilise targets, trap certain conformations and/or promote crystal packing. Here we present an example of using a single-chain variable fragment (scFv) to determine the previously unsolved structure of the multidomain protein SP140. This nuclear leukocyte-specific protein contains domains related to chromatin-mediated gene expression and has been implicated in various dis...
#1Cátia Fernandes-Cerqueira (KI: Karolinska Institutet)H-Index: 4
#2Nuria Renard (KI: Karolinska Institutet)H-Index: 1
Last.Susanna L. Lundström (KI: Karolinska Institutet)H-Index: 12
view all 8 authors...
IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in patients with idiopathic inflammatory myopathies (IIM) and anti-synthetase syndrome (ASS) with associated interstitial lung disease (ILD). Thus, we hypothesized that the total-IgG Fc-glycans from Jo1+ versus Jo1− patients and anti-Jo1-IgG would show characteristic differences, and that particular Fc-glycan features would be associat...
#1Michael FairheadH-Index: 7
#2Susanne GräslundH-Index: 21
Last.F. von DelftH-Index: 14
view all 16 authors...
#1Capucine Van Rechem (Harvard University)H-Index: 15
#2Joshua C. Black (Harvard University)H-Index: 17
Last.Johnathan R. Whetstine (Harvard University)H-Index: 28
view all 14 authors...
Single nucleotide polymorphisms (SNPs) occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence impact cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contribution, their use in sub-classifying patients and their impact on therapeutic response. We demonstrate that coding SNP-A482 within the lysine tri-demethylase KDM4A/JMJD2A associates with differential outcome in cancer pa...
#1Helena Persson (KTH: Royal Institute of Technology)H-Index: 3
#2Charlotta Preger (KI: Karolinska Institutet)H-Index: 1
Last.Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
view all 5 authors...
We describe a mass spectrometry-based approach for validation of antibody specificity. This method allows validation of antibodies or antibody fragments, against their endogenous targets. It can as ...
#1Susanne Gräslund (KI: Karolinska Institutet)H-Index: 21
#2Pavel Savitsky (University of Oxford)H-Index: 3
Last.Susanne Müller-Knapp (University of Oxford)H-Index: 3
view all 3 authors...
#1M. El BakkouriH-Index: 1
#2John R. WalkerH-Index: 50
Last.D.V. LovatoH-Index: 1
view all 9 authors...
#1M. El BakkouriH-Index: 1
#2John R. WalkerH-Index: 50
Last.D.V. LovatoH-Index: 1
view all 9 authors...
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